Актуальность

epidemiology

Эпидемиология и Вакцинопрофилактика

Epidemiology and Vaccinal Prevention

2073-30462619-0494

«Numicom» LLC

10.31631/2073-3046-2021-20-3-91-106

epidemiology-1294

Research Article

ОБЗОР

REVIEW

Вакцинопрофилактика у больных с хроническим лимфолейкозом

Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems

https://orcid.org/0000-0002-8794-0120

Кислова

М. И.

Kislova

M. I.

Мария Игоревна Кислова – cтудент; сотрудник лаборатории кариологии.

Москва

Maria I. Kislova – student of Sechenov University; karyology laboratory

Moscow

https://orcid.org/0000-0001-8461-5421

Петренко

А. А.

Petrenko

A. A.

Андрей Анатольевич Петренко – врач; аспирант

Москва

Andrei A. Petrenko – doctor; graduate student

Moscow

https://orcid.org/0000-0002-1382-9403

Костинов

М. П.

Kostinov

M. P.

Михаил Петрович Костинов – д. м. н., профессор, заведующий лабораторией вакцинопрофилактики и иммунотерапии аллергических заболеваний, профессор кафедры эпидемиологии и современных технологий вакцинации Института профессионального образования Сеченовского Университета.

Москва

Mikhail P. Kostinov – Dr. Sci. (Med.), professor, Honored Scientist of the Russian Federation, Head of the Laboratory of Vaccine Prophylaxis and Immunotherapy of Allergic Diseases, Professor of the Department of Epidemiology and Modern Technologies of Vaccination of Sechenov University.

Moscow

https://orcid.org/0000-0002-2490-1263

Никитин

Е. А.

Nikitin

E. A.

Евгений Александрович Никитин – д. м. н., профессор, заведующий дневным стационаром гематологии, онкологии и химиотерапии городского гематологического центра ГКБ им. С. П. Боткина»; заведующий кафедрой гематологии и трансфузиологии

125284, г.Москва, 2-й Боткинский пр-д, 5.

Eugene A. Nikitin – Dr. Sci. (Med.), professor, Head of the day hospital of hematology, oncology and chemotherapy of the city hematological center; Head of the Department of Hematology and Transfusiology

Moscow

ФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской Федерации; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияNational Research Center for Hematology, Moscow, Russian Federation; Sechenov First Moscow State Medical University (Sechenov University)Russian Federation

ГБУЗ Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияBotkin City Clinical Hospital; Russian Medical Academy of Continuous Professional EducationRussian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет); ФГБНУ «НИИ вакцин и сывороток им. И. И. Мечникова»РоссияSechenov First Moscow State Medical University (Sechenov University); I. Mechnikov Research Institute of Vaccines and SeraRussian Federation

2021

20072021

20391106

2021

Кислова М.И., Петренко А.А., Костинов М.П., Никитин Е.А.

Kislova M.I., Petrenko A.A., Kostinov M.P., Nikitin E.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epidemvac.ru/jour/article/view/1294

Актуальность

Актуальность. Инфекции являются наиболее частым осложнением хронического лимфолейкоза (ХЛЛ), согласно регистровым исследованиям, они становятся причиной смерти у 10–20% больных. Благодаря новым методам лечения ХЛЛ смертность, обусловленная прогрессией, снижается, тогда как летальность от инфекций в последние десятилетия остается постоянной.

Цель – анализ эффективности вакцинопрофилактики у пациентов с ХЛЛ по опубликованным данным, изучение предикторов неэффективности вакцинации, анализ текущих рекомендаций.

Заключение

Заключение. Механизмы иммунной дисфункции при ХЛЛ различны и связаны как с собственно заболеванием, так и с проводимой терапией. Результаты многочисленных исследований свидетельствуют о том, что у пациентов с ХЛЛ имеется неадекватный ответ на большинство вакцин, применяемых по стандартным схемам в общей популяции. Вакцинация у пациентов с ХЛЛ остается слабо разработанной темой. Необходимо проведение дополнительных клинических исследований с целью повышения эффективности вакцинации больных ХЛЛ

Relevance

Relevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from infections has remained constant in recent decades.

The aim of this literature review is to analyze the effectiveness of vaccine prophylaxis in patients with CLL as well as predictors of vaccine inefficiency according to published data, to explore current guidelines.

Conclusions

Conclusions. The mechanisms of immune dysfunction in CLL are complex and associated with both the disease itself and the therapy. Numerous studies have shown that patients with CLL have an inadequate response to most vaccines given routinely in the general population. Vaccination in CLL patients remains a poorly developed topic. Additional clinical trials are needed to improve the effectiveness of vaccination in patients with CLL.

хронический лимфолейкозвторичный иммунодефицитвакцинацияпневмококковая вакцинаантигриппозная вакцинанедостаточность специфических антител

сhronic lymphocytic leukemiasecondary immunodeficiencyvaccinationpneumococcal vaccinationinfluenza vaccinationantibody failure

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Приложение N 1 к приказу Министерства здравоохранения РФ от 21 марта 2014 г. № 125н “Об утверждении национального календаря профилактических прививок и календаря профилактических прививок по эпидемическим показаниям.”

Appendix No. 1 to the order of the Ministry of Health of the Russian Federation of March 21, 2014 No. 125n «On the approval of the national calendar of preventive vaccinations and the calendar of preventive vaccinations for epidemic indications.»

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Rubin L.G., Levin M.J., Ljungman P., et al. 2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host. 2014;58. DOI:10.1093/cid/cit684.

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The authors declare that there are no conflicts of interest present.