epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2021-20-6-100-107epidemiology-1405Research ArticleОБЗОРREVIEWМировой опыт применения менингококковых вакцин серогруппы В (обзор литературы)World Experience in the Use Serogroup B Meningococcal Vaccines (literature review)https://orcid.org/0000-0003-0578-146XКоролеваИ. С.KorolevaI. S.

Ирина Станиславовна Королева – д. м. н., заведующая лабораторией эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов

Москва

Irina S. Koroleva – Dr. Sci. (Med.), head of Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis

Moscow

irina-korol@yandex.ruhttps://orcid.org/0000-0002-2714-1191КоролеваМ. А.KorolevaM. A.

Мария Александровна Королева – к. м. н., старший научный сотрудник лаборатории эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов

Москва

Maria А. Koroleva  – Cand. Sci. (Med.), Senior Researcher, Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis

Moscow

korolevamaria389@gmail.comФБУН «Центральный научно-исследовательский институт эпидемиологии» РоспотребнадзораРоссияCentral Research Institute of Epidemiology of The Federal Service on Customers' Rights Protection and Human Well-being SurveillanceRussian Federation202106012022206100107Copyright © Королева И.С., Королева М.А., 20222022Королева И.С., Королева М.А.Koroleva I.S., Koroleva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/1405

Актуальность. Успех вакцинопрофилактики менингококковой инфекции зависит от состава и свойств вакцинных препаратов и строгого выполнения рекомендаций по тактике ее проведения и соответствия территориальным эпидемиологическим особенностям в отношении менингококковой инфекции. Несмотря на высокое бремя В-менингококковой инфекции, особенно среди детей младшего возраста, конструирование В-менингококковых вакцин столкнулось с серьезными трудностями. Цель. В литературном обзоре представить историю создания В-менингококковых вакцин и дать характеристику двум В-менингококковым вакцинным препаратам нового поколения. Заключение. Лицензирование представленных в обзоре двух новых В-менингококковых вакцин (Bexsero и Trumenba) основывалось на их иммуногенности и безопасности. Включение вакцин в национальные программы вакцинации требует тщательного анализа, в том числе анализа антигенных характеристик циркулирующих штаммов.

Relevance. The success of vaccine prophylaxis of meningococcal infection depends on the composition and properties of vaccine preparations and the strict implementation of recommendations on vaccine prophylaxis tactics by the territorial epidemiological characteristics of meningococcal infection. Despite the high burden of B-meningococcal infection, especially among young children, the design of B-meningococcal vaccines has faced serious difficulties. Aim. The literature review presents the history of the development of B-meningococcal vaccines and provides characteristics of two immunologically effective and safe new generation B-meningococcal vaccine preparations. Conclusion. The licensing of the two new B-meningococcal vaccines presented in the review (Bexsero and Trumenba) was based on immunogenicity and safety. The inclusion of vaccines in national vaccination programs requires careful analysis, including analysis of the antigenic characteristics of circulating strains.

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The authors declare that there are no conflicts of interest present.