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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2016-15-2-66-72</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-150</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВАКЦИНОПРОФИЛАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VACCINAL PREVENTION</subject></subj-group></article-categories><title-group><article-title>Вакцинирование детей с неврологическими нарушениями (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Vaccination for Children with Neurological and Genetic Violations (Literature Review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каплина</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaplina</surname><given-names>S. P.</given-names></name></name-alternatives><email xlink:type="simple">s.kaplina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харит</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharit</surname><given-names>S. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скрипченко</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skripchenko</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НИИ детских инфекций» ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Childhood Infection of the Federal Medical Biological Agency of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>04</month><year>2016</year></pub-date><volume>15</volume><issue>2</issue><fpage>66</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каплина С.П., Харит С.М., Скрипченко Н.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Каплина С.П., Харит С.М., Скрипченко Н.В.</copyright-holder><copyright-holder xml:lang="en">Kaplina S.P., Kharit S.M., Skripchenko N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/150">https://www.epidemvac.ru/jour/article/view/150</self-uri><abstract><p>Проблема поствакцинальных реакций на вакцины остается актуальной в течение многих лет. На сегодняшний день существует возможность вакцинопрофилактики детей с тяжелой патологией. Необходимость защиты детей с неврологической патологией от управляемых инфекций обусловлена высоким риском возникновения осложнений после перенесенных инфекций, от которых ребенок не был вовремя привит. В обзоре приводятся результаты исследований по безопасности, клинической и иммунологической эффективности вакцин против коклюша, дифтерии, кори и паротита у пациентов с патологией нервной системы. Имеющийся опыт показывает низкую частоту нежелательных явлений в поствакцинальном периоде при вакцинации детей с неврологическими нарушениями.</p></abstract><trans-abstract xml:lang="en"><p>The problem reactions on vaccines remains actual during many years. To date there is possibility vaccination of children with heavy pathology. The necessity of defence of children with neurological pathology from the guided infections is conditioned by the high risk of origin of complications after the carried infections from that a child was not in time instiled. To the review the results of researches on safety, clinical and immunological efficiency of vaccines are driven against a whooping-cough, diphtheria, measles and parotitis for patients with pathology of the nervous system. Had an experience shows frequency of the undesirable phenomena in a period after vaccination of children with neurological violations.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вакцинопрофилактика</kwd><kwd>патология нервной системы</kwd><kwd>поствакцинальные реакции</kwd><kwd>безопасность</kwd><kwd>эффективность</kwd><kwd>vaccination</kwd><kwd>pathology of the nervous system</kwd><kwd>postvaccinal reaction</kwd><kwd>safety</kwd><kwd>efficiency</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Костинов М. П., ред. Вакцинация детей с нарушенным состоянием здоровья: Москва, 4 МПресс. 2013: 432.</mixed-citation><mixed-citation xml:lang="en">Kostinov M. P., ed. Vaccination of children with impaired health condition: A Practical guide for physicians. Moscow: 4 MPress; 2013; 432 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Семенов Б.Ф., Воробьев А.А., Егорова Н.Б. Ожидаемые перспективы вакцинологии до 2020 года. В кн.: Фундаментальные направления молекулярной медицины. Санкт-Петербург; 2005: 328 - 392</mixed-citation><mixed-citation xml:lang="en">Semenov B. F., Vorob’ev A. A., Egorova N. B. Expected prospects vaccinology till 2020. In: The Fundamental areas of molecular medicine. Saint-Petersburg; 2005: 328 – 392(in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Семенов Б.Ф., Зверев В.В, Хаитов Р.М. Вакцинопрофилактика в XXI веке: настоящее и будущее. Иммунология. 2009; 6: 324 - 325.</mixed-citation><mixed-citation xml:lang="en">Semenov B.F., Zverev V.V, Haitov R.M. Vaccinal prevention in the XXI century: present and future. Immunology. 2009; 6: 324 – 325 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. Вакцинация детей в дополнение к календарю иммунопрофилактики. Лечащий врач. 2003;8: 55 - 59.</mixed-citation><mixed-citation xml:lang="en">Tatochenko V.K. Vaccination of children in addition to the vaccination calendar. Therapist. 2003; 8: 55 – 59 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Багдуева З.Ш. Перинатальная энцефалопатия как фактор риска поствакцинальных реакций и осложнений: Автореф. дис.. канд. мед. наук. Сара тов; 2004: 22.</mixed-citation><mixed-citation xml:lang="en">Bagdueva Z.Sh. Perinatal encephalopathy as a risk factor for post-vaccination reactions and complications: PhDofmed. sci. diss.Saratov; 2004: 22 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Медуницын Н.В. Вакцинология. Москва. Триада-Х, 2004: 448.</mixed-citation><mixed-citation xml:lang="en">Medunitsyin N.V. Vaccinology. M. Triada-X, 2004; 448 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Эсауленко Е.В., Коробочко М.Ю. Прививочные реакции и осложнения иммунопрофилактики. Санкт-Петербург; СПбГМУ; 2001: 39.</mixed-citation><mixed-citation xml:lang="en">Esaulenko E.V., Korobochko M.Yu. Vaccination reactions and complications of immunization. Saint Petersburg; 2001: 39 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Шниткова Е.В., Бурцев Е.М., Новиков А.Е., Философова М.С. Нервно-психическое здоровье детей, перенесших перинатальное поражение нервной системы. Журнал неврологии и психиатрии. 2000; 3: 57 - 59.</mixed-citation><mixed-citation xml:lang="en">Shnitkova E.V., Burtsev E.M., Novikov A.E., Filosofova M.S. Neuro-psychic health of children who suffered perinatal damage to the nervous system. Journal of Neurology and psychiatry. 2000; 3: 57 – 59 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Лазуренко С.Б. Анализ структуры патологических состояний новорожденных детей, приводящих к инвалидизации и их отдаленные последствия. Российский педиатрический журнал. 2009; 1: 49 - 52.</mixed-citation><mixed-citation xml:lang="en">LazurenkoS.B. Analysis of the structure of pathological States of newborns, leading to disability and long-term effects. Russian Journal of Pediatrics. 2009; 1: 49 – 52 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ахмадеева Э.Н., Валиулина А.Я., Брюханова О.А. Последствия церебральной ишемии у детей раннего возраста. Российский педиатрический журнал. 2008; 6: 50 - 52.</mixed-citation><mixed-citation xml:lang="en">Ahmadeeva E. N., Valiulina A. Ya., Bryuhanova O. A. Effects of the ischemia in infants. Russian Journal of Pediatrics. 2008; 6: 50 – 55 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева Е.А. Формирование здоровья детей с перинатальными поражениями центральной нервной системы, воспитывающихся в домах ребенка и детских домах, профилактика его нарушений: Автореф. дис.. д-ра мед. наук. Иваново; 2008: 38.</mixed-citation><mixed-citation xml:lang="en">Vorobeva E.A. Formation of health of children with perinatal lesions of the Central nervous system, brought up in children’s homes and orphanages, prevention of the violation: PhD of med. sci. diss. Ivanovo; 2008: 38 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Володин Н.Н. Перинатальная психология и психиатрия. Том 1. Раздел: Психологические дисциплины Перинатальная психология. Москва. Академия; 2009: 301.</mixed-citation><mixed-citation xml:lang="en">Volodin N.N. Perinatal psychology and psychiatry. Tom 1 Section: Psychological subject →Perinatal psychology. Moskow. Academy; 2009: 301 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Барашнев Ю.И., Розанов А.В., Волобуев А.И., Панов В.О. Инвалидность с детства: недифференцированная патология нервной системы и роль аномалий развития мозга. Российский вестник перинатологии и педиатрии. 2005; 3: 43 - 50.</mixed-citation><mixed-citation xml:lang="en">Barashnev Yu.I., Rozanov A.V., Volobuev A.I., Panov V.O. Disability in childhood: undifferentiated pathology of the nervous system and the role of abnormalities of brain development. Russian Gazette Perinatology and Pediatrics. 2005; 3: 43 – 50 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Басманова Е.Д., Перевощикова Н.К. Состояние здоровья детей - сирот и детей, оставшихся без попечения родителей. Российский педиатрический журнал. 2009; 4: 51 - 55.</mixed-citation><mixed-citation xml:lang="en">Basmanova E.D., Perevoschikova N.K. The health status of orphans and children left without parental care. Russian Journal of Pediatrics. 2009; 4: 51 – 55 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Пальчик А.Б., Шабалов Н.П., Шумилина А.П. Современные представления о перинатальной энцефалопатии. Российский педиатрический журнал. 2001; 1: 31 - 34.</mixed-citation><mixed-citation xml:lang="en">Palchik A. B., Shabalov N. P., Shumilina A. P. Modern concepts of perinatal encephalopathy. Russian Journal of Pediatrics. 2001; 1: 31 – 34 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Алямовская Г.А., Кешинян Е.С. Особенности физического развития на первом году детей с массой при рождении менее 1500 г. Российский вестник перинатологии и педиатрии. 2009; 3: 20 - 28.</mixed-citation><mixed-citation xml:lang="en">Alyamovskaya G.A., Keshinyan E.S. Features of physical development in the first year of children with birth weight less than 1500g. Russian Gazette Perinatology and Pediatrics. 2009; 3: 20 – 28 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Альбицкий В.Ю., Зелинская Д.И., Терлецкая Р.Н. Заболеваемость детей и инвалидность. Российский педиатрический журнал. 2008; 1: 32 - 35.</mixed-citation><mixed-citation xml:lang="en">Albitskiy V.Yu., Zelinskaya D.I., Terletskaya R.N. Children’s morbidity and disability. Russian Journal of Pediatrics. 2008; 1: 32 – 35 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Пальчик А.Б., Шабалов Н.П. Гипоксически-ишемическая энцефалопатия новорожденных. МЕДпресс-информ; 2013: 272.</mixed-citation><mixed-citation xml:lang="en">Palchik A.B., Shabalov N.P. Hypoxic-ischemic encephalopathy in neuborn: MEDpress-inform; 2012: 272 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Андреева Л.П., Кулешов Н.П., Мутовин Г.Р., Жилина С.С., Макарова В.П., Коровкина Е.А. Наследственные и врожденные болезни: вклад в детскую заболеваемость и инвалидность, подходы к профилактике. Педиатрия. 2007; 3: 8 - 14.</mixed-citation><mixed-citation xml:lang="en">Andreeva L.P., Kuleshov N.P., Mutovin G.R., Zhilina S.S., Макаrova V.P., Коrovkina Е.А. Hereditary and congenital diseases: contribution to children’s morbidity and disability, and approaches to prevention. Pediatrics.2007; 3: 8 – 14. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Roncarolo M.G., Bacchetta R, Bordingnon C., Narula S., Levings M.K. Type 1T regulatory cells. Immunol. Rev. 2001; 182: 68 - 79.</mixed-citation><mixed-citation xml:lang="en">Roncarolo M.G., Bacchetta R, Bordingnon C., Narula S., Levings M.K. Type 1T regulatory cells. Immunol. Rev. 2001; 182: 68 – 79.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлев Н.А., Слюсарь Т.А., Новоселова М.П. Психоиммунные, метаболические нарушения и подходы к их коррекции у детей с синдромом дефицита внимания-гиперактивности. Материалы X Юбилейной конференции «Нейроиммунология» 28 - 31 мая, Санкт-Петербург. 2001; 2: 223 - 297.</mixed-citation><mixed-citation xml:lang="en">Yakovlev N.A., Slyusar T.A., Novoselova M.P. Psychoimmunnyti, metabolic disorders and approaches to their correction in children with attention deficit disorder-hyperactivity. Proceedings of the X Сonferens «Neuroimmunology» 28-31 may, Saint Petersburg . 2001;V.2: 223-297 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Харит С.М., Черняева Т.В., Лакоткина Е.А. Опыт вакцинации часто болеющих детей. Вакцинация. 2004; 2: 6.</mixed-citation><mixed-citation xml:lang="en">Kharit S.M., Chernyaeva T.V., Lakotkina E.A. Experience of vaccination of sickly children. Vaccination. 2004; 2: 6 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Зиньковский К.Э. Клинико-патохимические, иммунологические изменения и их терапевтическая коррекция у больных с эпилепсией. Автореферат дисс.. канд. мед. наук. Москва; 2004: 24.</mixed-citation><mixed-citation xml:lang="en">Zinkovskiy K.E. Clinical and pathochemical, immunological changes and their therapeutic correction in patients with epilepsy. Doctorate of med. sci. diss. Moscow; 2004: 24 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Калинина Е.В. Иммунометаболические нарушения и их коррекция у детей с эпилепсий, длительно получающих антиконвульсанты. Автореферат дисс. канд. мед. наук. Курск; 2003: 22.</mixed-citation><mixed-citation xml:lang="en">Kalinina E.V. Immunometabolic disorders and their correction in children with epilepsy receiving long-anticonvulsants. Doctorate of med. sci. diss. Kursk; 2003: 22 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Гайсина Л. З. Особенности иммунного статуса и TNF-альфа при нестабильности генома у больных ранней резидуальной стадией детского церебрального паралича: Автореферат дисс. канд. мед. наук. Казань; 2013: 133.</mixed-citation><mixed-citation xml:lang="en">Gaysina L.Z. Features of immune status and TNF-alpha with genomic instability in patients with early residual stage of cerebral palsy. PhD of med. sci. diss. Kazan; 2013: 133 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Долгих Г.Б., Иваничев Г.А. Церебральные сосудистые нарушения у детей с детским церебральным параличом и судорожным синдромом. Казанский медицинский журнал. 2008; 3 (89): 315 - 319.</mixed-citation><mixed-citation xml:lang="en">Dolgih G.B., Ivanichev G.A. Cerebral vascular disorders in children with cerebral palsy and seizures. Kazan medical journal. 2008; 3 (89): 315 – 319 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Харсеева Г.Г., Москаленко Е.П., Федорук С.И. Противодифтерийный иммунитет у детей после вакцинации АКДС-вакциной и АДС-М-анатоксином. Журнал микробиологии, эпидемиологии и иммунологии. 2006; 1: 67 - 69.</mixed-citation><mixed-citation xml:lang="en">Harseeva G.G., Moskalenko E.P., Fedoruk S.I. Anti-diphtheria immunity in children after vaccination with the DPT vaccine and ADT-M toxoid. Journal of Microbiology, Epidemiology and Immunology. 2006; 1: 67 – 69 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. Безопасность вакцинации: современные данные. Педиатрическая фармакология. 2007;3: 73.</mixed-citation><mixed-citation xml:lang="en">Tatochenko V.K. Safety of vaccination: current data. Pediatric pharmacology. 2007; 3: 73 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pandolfi E., Carloni E., Marino M.G., Ciofidegliatti M.L., Gesualdo F., Romano M. et al. Immunization coverage and timeliness of vaccination in Italian children with chronic diseases. Vaccine. 2012; 30 (34): 5172 - 5178.</mixed-citation><mixed-citation xml:lang="en">Pandolfi E., Carloni E., Marino M.G., Ciofidegliatti M.L., Gesualdo F., Romano M. et al. Immunization coverage and timeliness of vaccination in Italian children with chronic diseases. Vaccine. 2012; 30 (34): 5172 – 5178.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Соловьева И.Л. Особенности вакцинального процесса и способы повышения эффективности вакцинации против гепатита в, кори, эпидемического паротита у детей с измененным преморбидным фоном. Автореферат дисс. докт. мед. наук. Москва; 2006.</mixed-citation><mixed-citation xml:lang="en">Soloveva I.L. The peculiarities of the vaccination process and ways to improve the effectiveness of vaccination against hepatitis b, measles, mumps in children with premorbid modified background. PhD of med. sci. diss. Moscow; 2006 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Greenwood V.J., Crawford N.W., Walstab J.E., Reddihough D.S. Immunisation coverage in children with cerebral palsy compared with the general population. J Paediatr Child Health.2013; 49 (2): E137 - E141.</mixed-citation><mixed-citation xml:lang="en">Greenwood V.J., Crawford N.W., Walstab J.E., Reddihough D.S. Immunisation coverage in children with cerebral palsy compared with the general population. J Paediatr Child Health.2013; 49 (2): E137 – E141.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Goldman G.S., Miller N.Z. Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990 - 2010. Human and Experimental Toxicology 31; (10): 1012 - 1021.</mixed-citation><mixed-citation xml:lang="en">Goldman G.S., Miller N.Z.. Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990 – 2010. Human and Experimental Toxicology; 31 (10): 1012 – 1021.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Griffin M.R., Ray W.A., Livengood J.R., Schaffner W. Risk of sudden infant death syndrome after immunization with the diphtheria-tetanus-pertussis vaccine. N. Engl. J. Med. 1988; 319 (10): 618 - 623.</mixed-citation><mixed-citation xml:lang="en">Griffin M.R., Ray W.A., Livengood J.R., Schaffner W. Risk of sudden infant death syndrome after immunization with the diphtheria-tetanus-pertussis vaccine. N. Engl. J. Med., 1988; 319 (10): 618 – 623.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Daley M.F., Yih W.K., Glanz J.M., Hambidge S.J., Narwaney K.J., Yin R, Li L. еt al. Safety of diphtheria, tetanus, acellular pertussis and inactivated poliovirus (DTaP-IPV) vaccine. Vaccine. 2014; 32 (25); 3019 - 24.</mixed-citation><mixed-citation xml:lang="en">Daley M.F., Yih W.K., Glanz J.M., Hambidge S.J., Narwaney K.J., Yin R., Li L. еt al. Safety of diphtheria, tetanus, acellular pertussis and inactivated poliovirus (DTaP-IPV) vaccine. Vaccine. 2014; 32 (25); 3019 – 3024.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Шмелёва Н.Д., Коломиец Н.Д., Тонко О.В., Ханенко О.Н. Изучение диапазона поствакцинальных клинических проявлений при введении АКДС вакцины. Настоящее и будущее последипломного образования: Материалы респ. науч-практ. конф., посвященной 75-летию БелМАПО. Минск.2006; 2: 549 - 553.</mixed-citation><mixed-citation xml:lang="en">Shmelyova N.D., Kolomiets N.D., Tonko O.V., Hanenko O.N. To explore the range of vaccine-related clinical manifestations when administered DTP vaccine. Present and future of postgraduate education: proceedings of the resp. scientific-practical. conference dedicated to the 75th anniversary of BelMAPO. Minsk. 2006; 2: 549 – 553 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Воронина О. Л. Клинико-иммунологическая характеристика заболеваний поствакцинального периода и разработка мер их профилактики: Автореферат дисс. канд. мед. наук. Санкт-Петербург; 2008: 137.</mixed-citation><mixed-citation xml:lang="en">Voronina O. L. Clinical and immunological characteristics of diseases post-vaccination period and the development of preventive measures.PhD of med. sci. diss. Sankt-Peterburg; 2008: 137 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Махмудова Д.И., Низамова З.А. Течение поствакцинального периода и показатели сероконверции у детей с перинатальным поражением ЦЦНС на АКДС и коревую вакцинацию. Врач-аспирант. 2011; 2.2: 372 - 381.</mixed-citation><mixed-citation xml:lang="en">Mahmudova D.I., Nizamova Z.A. The vaccinal period and indicators of seroconversion in children with perinatal lesions of nervous systemfor DTP and measles vaccination. Doctor graduate-student. 2011; 2.2: 372 – 381 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sun Y., Christensen J., Hviid A., Li J., Vedsted P., Olsen J. et al. Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type B. JAMA 2012; 307: 823 - 831.</mixed-citation><mixed-citation xml:lang="en">Sun Y., Christensen J., Hviid A., Li J., Vedsted P., Olsen J. et al. Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type B. JAMA. 2012; 307: 823 – 831.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Principi N., Esposito S. Vaccines and febrile seizures. Expert. Rev. Vaccines. 2013; 12 (8); 885 - 892.</mixed-citation><mixed-citation xml:lang="en">Principi N., Esposito S. Vaccines and febrile seizures.ExpertRevVaccines. 2013; 12 (8); 885 – 892.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ольховиков А.И., Самарина О.В., Блат Н.В. Вакцинация детей против коклюша с органической патологией центральной нервной системы. Уральский медицинский журнал. 2008; 4: 44 - 47.</mixed-citation><mixed-citation xml:lang="en">Olhovikov A.I., Samarina O.V., Blat N.V. Vaccination of children against pertussis with organic pathology of the Central nervous system. Ural medical journal. 2008;4: 44 – 47 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Beyazova U., Yuksel N., Aksakal F.N., Camurdan A.D. Comparison of the reactogenicity of three different immunization schedules including diphtheria, tetanus, pertussis, Haemophilus influenza b and polio vaccine in Turkey. Transactions of the Royal Society of Tropical Medicine and Hygiene; 2013.</mixed-citation><mixed-citation xml:lang="en">Beyazova U., Yuksel N., Aksakal F.Nur., Camurdan A.Duyan. Cjmparison of the reactogenicity of three different immunization schedules including diphtheria, tetanus, pertussis, Haemophilus influenza b and polio vaccine in Turkey. Transactions of the Royal Society of Tropical Medicine and Hygiene; 2013.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Bonanni P., Sacco C., Donato R., Capei R. Lifelong vaccination as a key disease-prevention strategy. Clinical microbiology and infection the official publication of the European Society of Clinical Microbiology and Infectious Diseases. Clin. Microbiol. Infect. 2014; 20 (5): 32 - 6.</mixed-citation><mixed-citation xml:lang="en">Bonanni P., Sacco C., Donato R., Capei R. Lifelong vaccination as a key disease-prevention strategy. Clinical microbiology and infection the official publication of  the European Society of Clinical Microbiology and Infectious Diseases. Clin. Microbiol. Infect. 2014; 20 (5): 32 – 36.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Вдовицына Н.А., Ишеева Е.Н., Толпинская И.А. Оценка безопасности и реактогенности вакцин против коклюша, дифтерии, столбняка. Материалы VIII Конгресса детских инфекционистов в России «Актуальные вопросы инфекционной патологии и вакцинопрофилактика у детей». Москва; 2009: 26 - 27.</mixed-citation><mixed-citation xml:lang="en">Vdovitsyina N.A., Isheeva E.N., Tolpinskaya I.A. Evaluation of safety and reactogenicity of vaccines against pertussis, diphtheria, tetanus. Proceedings of the VIII Congress childhood infectious disease in Russia «Topical issues of infectious diseases and vaccine prevention in children». Moscow; 2009: 26 – 27.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Снегова Н.Ф., Пушко Л.В., Илларионова Т.Ю., Салкина О.А., Смирнова Ю.В. Результаты применения комбинированной вакцины против дифтерии, коклюша, столбняка, полиомиелита и гемофильной инфекции типа В у детей с сопутствующими заболеваниями. Вопросы современной педиатрии. 2011; 1: 115 - 118.</mixed-citation><mixed-citation xml:lang="en">Snegova N.F., Pushko L.V., Illarionova T.Yu., Salkina O.A., Smirnova Yu.V. The results of the application of a combination vaccine against diphtheria, pertussis, tetanus, polio and Haemophilus influenzae type b in children with underlying medical  conditions. Current pediatrics. 2011; 1: 115 – 118 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Рычкова О.А., Казакевич Н.В., Сенникова Н.П., Чемакина Д.С. Опыт применения комбинированной вакцины против дифтерии, коклюша, столбняка, полиомиелита и гемофильной инфекции типа В у здоровых и детей с различными нарушениями здоровья. Педиатрическая фармакология. 2011; 4: 76 - 81.</mixed-citation><mixed-citation xml:lang="en">Ryichkova O.A., Kazakevich N.V., Sennikova N.P., Chemakina D.S. The results of the application of a combination vaccine against diphtheria, pertussis, tetanus,  polio and Haemophilus influenzae type b in children with underlying medical  conditions. Pediatric pharmacology. 2011; 4: 76 – 81(in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira C.T., Leite J.C., Taniguchi A., Vieira S.M., Pereira-Lima J., da Silveira T.R. J. Pediatr Gastroenterol Nutr. 2004; 39 (4): 337 - 40.</mixed-citation><mixed-citation xml:lang="en">Ferreira C.T., Leite J.C., Taniguchi A., Vieira S.M., Pereira-Lima J., da Silveira T.R. J. Pediatr. Gastroenterol. Nutr. 2004; 39 (4): 337 – 340.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Голубкова А.А., Харитонов А.Н., Кетова И.Л., Гусев Н.М. Опыт комбинированного применения вакцин у детей с органическим повреждением нервной системы. Педиатрия. Журнал им. Г.Н. Сперанского. 2000; 5: 11.</mixed-citation><mixed-citation xml:lang="en">Golubkova A.A., Haritonov A.N., Ketova I.L., Gusev N.M. Experience of combined use of vaccines in children with organic damage to the nervous system. Pediatrics. 2000; 5: 11 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Воронина О.Л., Харит С.М., Черняева Т.В., Фридман И.В. Характеристика заболеваний поствакцинального периода у привитых АКДС. Материалы VI Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики у детей». Санкт-Петербург; 2007: 44.</mixed-citation><mixed-citation xml:lang="en">Voronina O.L., Kharit S.M., Chernyaeva T.V., Fridman I.V. Characteristics of the disease post-vaccination period in vaccinated DTP. Proceedings of the VI Congress  childhood infectious diseases Russia «Topical issues of infectious diseases and  vaccine prevention in children». Saint Petersburg; 2007: 44 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Новикова О.В. Особенности формирования специфического иммунитета на противокоревую вакцинацию у часто болеющих детей: Автореф. дис. канд. мед. наук. Душанбе; 2001: 22.</mixed-citation><mixed-citation xml:lang="en">Novikova O.V. Peculiarities of formation of specific immunity in measles vaccination in frequently ill children: PhD of med. sci. diss. Dushanbe; 2001: 22. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Галазка М. Дифтерия. Иммунологические основы вакцинации. Женева: ВОЗ; 1993: 24.</mixed-citation><mixed-citation xml:lang="en">Galazka M. Diphtheria. Immunological basis of vaccination. Zheneva: VOZ; 1993: 24.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Галазка М. Столбняк. Иммунологические основы вакцинации. Женева: ВОЗ; 1993: 39.</mixed-citation><mixed-citation xml:lang="en">Galazka M. Tetanus. Immunological basis of vaccination. Zheneva: VOZ; 1993: 39.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Бектимиров Т.А. Принципы оценки иммунологической эффективности вакцин. Биопрепараты. 2001; 1: 14 - 16.</mixed-citation><mixed-citation xml:lang="en">Bektimirov T.A. Principles for evaluating immunological efficacy of vaccines. Biologics. 2001; 1: 14 – 16 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Брико Н. И. Критерии оценки эффективности вакцинации. Лечащий врач. 2001; 3: 64 - 70.</mixed-citation><mixed-citation xml:lang="en">Briko N.I. Criteria for evaluating the effectiveness of vaccination / N.I. Briko // Therapist. 2001; 3: 64 – 70 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards K.M., Berbers G.A. Immune responses to pertussis vaccines and disease. J. Infect. Dis. 2014; 209 (l): 10 - 15.</mixed-citation><mixed-citation xml:lang="en">Edwards K.M., Berbers G.A. Immune responses to pertussis vaccines and disease. J. Infect. Dis. 2014; 209 (l): 10 – 15.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Харсеева Г.Г., Москаленко Е.П., Федорук С.И. и др. Противодифтерийный иммунитет у детей после вакцинации АКДС-вакциной и АДС-М-анатоксином. Журнал микробиологии, эпидемиологии и иммунологии. 2006;1: 67 - 69.</mixed-citation><mixed-citation xml:lang="en">Harseeva G.G., Moskalenko E.P., Fedoruk S.I. et. al. Anti-diphtheria immunity in children after vaccination with the DPT vaccine and ADT-M toxoid. Journal Microbiology, Epidemiology and immunology. 2006; 1: 67 – 69 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Wendelboe A. M., Van Rie A., Salmaso S., Englund J. A. Duration of immunity against pertussis after natural infection or vaccination. Pediat. Infect. Dis. J. 2005; 24 (5): 58 - 61.</mixed-citation><mixed-citation xml:lang="en">Wendelboe A. M., Van Rie A., Salmaso S., Englund J.A. Duration of immunity against pertussis after natural infection or vaccination. Pediat. Infect. Dis. J. 2005; 24 (5): 58 – 61.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев Е.М., Мазурова И.К., Краснопрошина Л.И. Гуморальный противококлюшный иммунитет и распространенность коклюша в популяции. Журнал микробиологии, эпидемиологии и иммунологии. 2009; 1: 56 - 58.</mixed-citation><mixed-citation xml:lang="en">Zaytsev E.M., Mazurova I.K., Krasnoproshina L.I. Humoral immunity to pertussis and prevalence of pertussis in the population Journal Microbiology, Epidemiology and immunology. 2009; 1: 56 – 58 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Liese J.G., Stojanov S., Peters A. et al. Duration of efficacy after primary immunization with bikenacellular pertussis vaccine. Abstract G-2050.Programs and abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL; 2003.</mixed-citation><mixed-citation xml:lang="en">Liese J.G., Stojanov S., Peters A. et al. Duration of efficacy after primary immunization with biken acellular pertussis vaccine. Abstract G-2050.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Балаболкин И.И., Сюракшина М.В. Аллергические заболевания у детей и профилактические прививки. Лечащий врач; 2005; 9: 18 - 21.</mixed-citation><mixed-citation xml:lang="en">Programs and abstracts of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL; 2003.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А.А., Намазова-Баранова Л.С., Таточенко В.К. Научное обоснование вакцинации детей с отклонениями в состоянии здоровья. Педиатрическая фармакология. 2010; 2: 6 - 22.</mixed-citation><mixed-citation xml:lang="en">Balabolkin I.I., Syurakshina M.V. Allergic diseases in children and immunizations. Therapist. 2005; 9: 18 – 21 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Махмудова Д.И., Низамова З.А. Течение поствакцинального периода и показатели сероконверции у детей с перинатальным поражением ЦЦНС на АКДС и коревую вакцинацию. Врач-аспирант. 2011;2.2: 372 - 38.</mixed-citation><mixed-citation xml:lang="en">Baranov A.A., Namazova-Baranova L.S., Tatochenko V.K. Scientific justification for vaccination of children with deviations in health status. Pediatric pharmacology. 2010; 2: 6 – 22 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Заргарьянц А.И., Яковлева И.В., Селезнева Т.С., Свиридов В.В., Белевская А.А. Длительность и напряженность поствакцинального гуморального иммунитета к вирусу кори, паротита и краснухи. Эпидемиология и Вакцинопрофилактика. 2005; 5: 15 - 19.</mixed-citation><mixed-citation xml:lang="en">Mahmudova D.I., Nizamova Z.A. The vaccinal period and indicators of seroconversion in children with perinatal lesions of nervous system for DTP and measles vaccination. Doctor-aspirant. 2011; 2.2: 372 – 381 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Зверев В.В., Юминова Н.В. Эффективность вакцинации против кори и эпидемического паротита. Вакцинация. 2000; 11 (5): 10 - 11.</mixed-citation><mixed-citation xml:lang="en">Zargaryants A.I., Yakovleva I.V., Selezneva T.S., Sviridov В.В., Belevskaya The duration and intensity of postvaccinalhumoral immunity to measles, mumps, and rubella. Journal Microbiology, Epidemiology and immunology. 2005; 5 (24): 15 – 19 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Ляшенко В.А., Краснопрошина Л.И., Александер С.К., Сходова С.А. Отсроченные результаты вакцинации часто болеющих детей против кори и эпидемического паротита. Журнал микробиологии, эпидемиологии и иммунобиологии. 2010; 2: 60 - 64.</mixed-citation><mixed-citation xml:lang="en">Zverev V.V.,Yuminova N.V. The effectiveness of vaccination against measles and mumps. Vaccination. 2000; 11 (5): 10 – 11(in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Lyashenko V.A., Krasnoproshina L.I., Aleksander S.K., Shodova S.A. Long-term results of vaccination of sickly children against measles and mumps. Journal Microbiology, Epidemiology and immunology. 2010; 2: 60 – 64 (in Russian).</mixed-citation><mixed-citation xml:lang="en">Lyashenko V.A., Krasnoproshina L.I., Aleksander S.K., Shodova S.A. Long-term results of vaccination of sickly children against measles and mumps. Journal Microbiology, Epidemiology and immunology. 2010; 2: 60 – 64 (in Russian).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
