epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2022-21-3-107-116epidemiology-1565Research ArticleОБЗОРREVIEWЭнтеровирусный везикулярный стоматит с экзантемой: эпидемиологические особенности и вакцинопрофилактикаEnterovirus vesicular stomatitis with exanthema: Epidemiological Features and Vaccinationhttps://orcid.org/0000-0003-2412-5329СытаяЮ. С.SytayaYu. S.

Юлия Сергеевна Сытая – студентка Института Общественного Здоровья им. Ф. Ф. Эрисмана (Сеченовский Университет)

119435, г. Москва, ул. Б. Пироговская, д.2, стр.2

+7 (901) 778-24-37

Yulia S. Sytaya – student of Institute of Public Health (Sechenov University)

2/2, Bolshaya Pirogovskaya str., Moscow, 119435

+7 (901) 778-24-37

julia.98.med.university@mail.ruhttps://orcid.org/0000-0001-7081-3582МиндлинаА. Я.MindlinaA. Ya.

Алла Яковлевна Миндлина – д. м. н., профессор кафедры эпидемиологии и доказательной медицины

119435, г. Москва, ул. Б. Пироговская, д.2, стр.2

+7 (916) 935-38-51

Alla Ya. Mindlina – Dr. Sci. (Med.), Professor of Department of Epidemiology and Evidence-based medicine

2/2, Bolshaya Pirogovskaya str., Moscow, 119435

+7  (916) 935-38-51

mindlina@1msmu.ruФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)РоссияSechenov UniversityRussian Federation202210072022213107116Copyright © Сытая Ю.С., Миндлина А.Я., 20222022Сытая Ю.С., Миндлина А.Я.Sytaya Y.S., Mindlina A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/1565

Актуальность. В РФ регистрируются эпидемические вспышки энтеровирусного везикулярного стоматита (ЭВС) с экзантемой, характеризующиеся вовлечением детей и тяжелым течением. Кроме того, РФ граничит с Восточной и Юго-Восточной Азией (свыше 2 млн госпитализаций с диагнозом «ЭВС с экзантемой»), что предопределяет высокий риск заноса возбудителя инфекции на территорию страны. При этом во всем мире уровень летальности варьирует и может составлять от 6,46 до 51,0 на 100 тыс. населения. Цель. По данным литературы проанализировать эпидемиологические характеристики ЭВС с экзантемой в РФ и мире, а также перспективы вакцинопрофилактики данной инфекции. Выводы. По данным современной литературы, ЭВС с экзантемой – наиболее распространенная клиническая форма ЭВИ, которая отличается высокой гетерогенностью возбудителей. На протяжении последних лет заболеваемость ЭВИ во многих субъектах РФ характеризуется тенденцией к росту. Наиболее неблагоприятная эпидемическая ситуация в РФ наблюдается на территории Дальневосточного федерального округа, где регистрируется наибольшее количество случаев ЭВИ. В 2018 г. в Сахалинской обл. выявлено 1058 случаев ЭВИ (222,6 случаев на 100 тыс.). В структуре ЭВИ в РФ преобладают экзантемные формы, герпангина и гастроэнтерит. Следует рассматривать вопрос о введении вакцинации детского населения, поскольку на территории РФ ежегодно регистрируются подъемы заболеваемости ЭВИ в различных регионах. В Китае по эпидемическим показаниям уже применяются вакцины против EV-A71. Активная циркуляция возбудителей ЭВС с экзантемой в Азиатско-Тихоокеанском регионе может повлиять на распространение ЭВИ на территории РФ, поскольку повышается риск завозных случаев инфекции и формирования эпидемических очагов групповой заболеваемости.

Relevance. Hand, foot and mouth disease (HFMD) is a disease that is extremely relevant for the Russian Federation. According to modern data, epidemic outbreaks of severe course involving a large number of children are registered in the Russian Federation. At the same time, the mortality rate varies worldwide and can range from 6.46 to 51.00 per 100 thousand population. In addition, the fact that the Russian Federation borders with East and Southeast Asia annually increases the risk of HFMD entering the territory of Russia. Every year, the disease causes more than 2 million hospitalizations in Asia. Aims. According to the literature, to analyze the epidemiological characteristics of HFMD in the Russian Federation and the world, as well as the prospects for vaccination of this infection. To achieve this goal, open sources hosted in the electronic databases PubMed, Medline and e-Library were used. Publications on enterovirus infection for the period from 2014 to 2022 are analyzed. The WHO (Western Pacific Region) statistics on HFMD were also used. Results. According to the modern literature, HFMD is the most common clinical form of enterovirus infection, which is characterized by high heterogeneity of pathogens. Over the past few years, the incidence of enterovirus infection in many subjects of the Russian Federation has been characterized by an upward trend. The most unfavorable epidemic situation in the Russian Federation is observed on the territory of the Far Eastern Federal District, where the largest number of cases of enterovirus infection is registered. In 2018, 1058 cases of enterovirus infection were detected in the Sakhalin region (222.6 cases per 100 thousand). The structure of enterovirus infection in the Russian Federation is dominated by exanthemic forms, herpangina and gastroenteritis. It is necessary to consider the introduction of vaccination of the child population, since rises in the incidence of enterovirus infection in various regions are registered annually on the territory of the Russian Federation. Vaccines against EV-A71 are already being used in China for epidemic indications. The active circulation of HFMD in the Asia-Pacific region may affect the spread of enterovirus infection in the territory of the Russian Federation, as the risk of imported cases of infection and the formation of epidemic foci of group morbidity increases.

обзорэнтеровирусный везикулярный стоматит с экзантемойэпидемическая ситуациявакцинывакцинопрофилактикаreviewenterovirus vesicular stomatitis with exanthemaepidemic situationvaccinesvaccinationReferencesDuan X., Zhang C., Chen Z., et al. Dynamic changes of viral load and the duration of viral shedding in patients with hand, foot and mouth disease: a protocol for longitudinal study BMC Infect Dis. 2022. Vol. 22, N 1. P. 162.Duan X, Zhang C, Chen Z, et al. Dynamic changes of viral load and the duration of viral shedding in patients with hand, foot and mouth disease: a protocol for longitudinal study. BMC Infect Dis. 2022;22(1):162. doi:10.1186/s12879-022-07131-wEsposito S., Principi N. Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention Eur J Clin Microbiol Infect Dis. 2018. Vol. 37, N3. P. 391–398.Esposito S, Principi N. Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention. Eur J Clin Microbiol Infect Dis. 2018;37(3):391–398. doi: 10.1007/s10096-018-3206-xГолицына Л. Н., Нгуен Т. Т., Романенкова Н. И. и др. Энтеровирусная инфекция в Социалистической Республике Вьетнам Инфекция и иммунитет. 2019. Т. 9, № 3-4. С. 467–475.Golitsyna LN, Nguyen TT, Romanenkova NI, et al. Enterovirus infection in the Socialist Republic of Vietnam. Russian Journal of Infection and Immunity. 2019;9(3–4):467–475. (In Russ).  https:doi.org/10.15789/2220-7619-2019-3-4-467-475Zhang C., Chen S., Zhou G., et al. Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease PLoS One. 2018. Vol. 13, N5. P. e0197861.Zhang C, Chen S, Zhou G, et al. Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. PLoS One. 2018;13(5):e0197861. doi:10.1371/journal.pone.0197861Кокорева С. П., Казарцева Н. В., Котлова В. Б. Эволюция клинико-лабораторных особенностей энтеровирусного менингита у детей Детские инфекции. 2019. Т. 18, № 4. С. 43–48.Kokoreva SP, Kazartseva NV, Kotlova VB. The evolution of clinical and laboratory features enteroviral meningitis in children. Children Infections. 2019;18(4):43–48 (In Russ). https:doi.org/10.22627/2072-8107-2019-18-4-43-48Бутакова Л. В., Троценко О. Е., Сапега Е. Ю. Энтеровирусная инфекция: обзор ситуации в мире на современном этапе в условиях активизации миграционных процессов Здоровье населения и среда обитания. 2018. № 4. С. 55–60.Butakova LV, Trotsenko OE, Sapega EYu. Enterovirus infection: overview of the current global situation in the context of intensified migration flows. Public Health and Life Environment. 2018;(4):55–60 (In Russ).Jia J., Kong F., Xin X., et al. Epidemiological Characteristics of Hand, Foot, and Mouth Disease Outbreaks in Qingdao, 2009-2018 Iran J Public Health. 2021. Vol. 50. N 5. P. 999–1008.Jia J, Kong F, Xin X, et al. Epidemiological Characteristics of Hand, Foot, and Mouth Disease Outbreaks in Qingdao, 2009–2018. Iran J Public Health. 2021;50(5):999–1008. doi:10.18502/ijph.v50i5.6117Chen M., He S., Yan Q., et al. Sporadic hand, foot, and mouth disease cases associated with non-C4 enterovirus 71 strains in Xiamen, China, from 2009 to 2018 Arch Virol. 2021. Vol. 166. N 8. P. 2263–2266.Chen M, He S, Yan Q, et al. Sporadic hand, foot, and mouth disease cases associated with non-C4 enterovirus 71 strains in Xiamen, China, from 2009 to 2018. Arch Virol. 2021;166(8):2263–2266. doi:10.1007/s00705-021-05097-9Chen C., Jiang Q., Song Z., et al. Influence of temperature and humidity on hand, foot, and mouth disease in Guangzhou, 2013–2017 J Int Med Res. 2020. N6. P. 300060520929895.Chen C, Jiang Q, Song Z, et al. Influence of temperature and humidity on hand, foot, and mouth disease in Guangzhou, 2013–2017. J Int Med Res. 2020;48(6):300060520929895. doi:10.1177/0300060520929895Luo C., Ma Y., Liu Y., et al. The burden of childhood hand-foot-mouth disease morbidity attributable to relative humidity: a multicity study in the Sichuan Basin, China Sci Rep. 2020. Vol. 10, N1. P. 19394.Luo C, Ma Y, Liu Y, et al. The burden of childhood hand-foot-mouth disease morbidity attributable to relative humidity: a multicity study in the Sichuan Basin, China. Sci Rep. 2020;10(1):19394. doi:10.1038/s41598-020-76421-7Wang X., Liu H., Li Y., et al. Relationship between polymorphism of receptor SCARB2 gene and clinical severity of enterovirus-71 associated hand-foot-mouth disease. Virol J. 2021. Vol. 18. N 1. P. 132.Wang X, Liu H, Li Y, et al. Relationship between polymorphism of receptor SCARB2 gene and clinical severity of enterovirus-71 associated hand-foot-mouth disease. Virol J. 2021;18(1):132. doi:10.1186/s12985-021-01605-0Xu S., Li H., Qiao P, et al. Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai. BMC Pediatr. 2020. Vol. 20, N 1. P. 364.Xu S, Li H, Qiao P, et al. Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai. BMC Pediatr. 2020;20(1):364. doi:10.1186/s12887-020-02262-yTyring S.K. Hand foot and mouth disease: Enteroviral load and disease severity. EBioMedicine. 2020. Vol. 62. P. 103115.Tyring SK. Hand foot and mouth disease: Enteroviral load and disease severity. EBioMedicine. 2020; 62:103115. doi:10.1016/j.ebiom.2020.103115Hu P., Liu J., Gan L, et al. Lack of effective home quarantine: The cause of the continuing prevalence of hand, foot, and mouth disease in China J Infect Public Health. 2020. Vol. 13, N 7. P. 963–969.Hu P, Liu J, Gan L, et  al. Lack of effective home quarantine: The cause of the continuing prevalence of hand, foot, and mouth disease in  China? J Infect Public Health. 2020;13(7):963–969. doi: 10.1016/j.jiph.2020.05.011Jin Y., Li D., Sun T., et al. Pathological Features of Enterovirus 71-Associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analysis Front Microbiol. 2021. N 12. P. 663019.Jin Y, Li D, Sun T, et  al. Pathological Features of Enterovirus 71-Associated Brain and Lung Damage in  Mice Based on Quantitative Proteomic Analysis.  Front Microbiol. 2021;12:663019. doi:10.3389/fmicb.2021.663019Kua J.A., Pang J. The epidemiological risk factors of hand, foot, mouth disease among children in Singapore: A retrospective case-control study PLoS One. 2020. Vol. 15, N 8. P. e0236711.Kua JA, Pang J. The epidemiological risk factors of hand, foot, mouth disease among children in Singapore: A retrospective case-control study. PLoS One. 2020;15(8):e0236711. doi:10.1371/journal.pone.0236711Guo N., Ma H., Deng J., et al. Effect of hand washing and personal hygiene on hand food mouth disease: A community intervention study Medicine (Baltimore). 2018. Vol. 97, N 51. P. e13144.Guo N, Ma H, Deng J, et  al. Effect of hand washing and personal hygiene on hand food mouth disease: A community intervention study. Medicine (Baltimore). 2018;97(51):e13144. doi:10.1097/MD.0000000000013144Wang X., An Z., Huo D., et al. Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China Hum Vaccin Immunother. 2019. Vol. 15, N 5. P. 1183–1190.Wang X, An Z, Huo D, et al. Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China. Hum Vaccin Immunother. 2019;15(5):1183–1190. doi:10.1080/21645515.2019.1581539Алимов А. В., Игонина Е. П., Фельдблюм И. В. и др. Современное состояние проблемы энтеровирусных (неполио) инфекций, связанных с оказанием медицинской помощи Инфекция и иммунитет. 2020. Т. 10. № 3. С. 486–496.Alimov AV, Igonina EP, Feldblyum IV, et  al. Current status of healthcare-associated enteroviral (non-polio) infections.  Russian Journal of Infection and Immunity. 2020;10(3):486–496 (In Russ). https:doi.org/10.15789/10.15789/2220-7619-CSF-1161Rui J., Luo K., Chen Q., et al. Early warning of hand, foot, and mouth disease transmission: A modeling study in mainland, China PLoS Negl Trop Dis. 2021. Vol. 15, N 3. P. e0009233.Rui J, Luo K, Chen Q, et al. Early warning of hand, foot, and mouth disease transmission: A modeling study in mainland, China. PLoS Negl Trop Dis. 2021;15(3):e0009233. doi:10.1371/journal.pntd.0009233Лукашев А. Н., Голицына Л. Н., Вакуленко Ю. А. и др. Современные возможности и направления развития молекулярно-эпидемиологического мониторинга в надзоре за энтеровирусными инфекциями. Опыт Российской Федерации Инфекция и иммунитет. 2018. Т. 8, № 4. С. 452–464.Lukashev AN, Golitsina LN, Vakulenko YuA, et al.Current possibilities and potential development of molecular enterovirus surveillance. Experience of Russian Federation. Russian Journal of Infection and Immunity. 2018;8(4):452–464 (In Russ). https:doi.org/10.15789/2220-7619-2018-4-452-464.Owino C.O., Chu J.J.H. Recent advances on the role of host factors during non-poliovirus enteroviral infections J Biomed Sci. 2019. Vol. 26. N 1. P. 47.Owino CO, Chu JJH. Recent advances on the role of host factors during non-poliovirus enteroviral infections. J Biomed Sci. 2019;26(1):47. doi:10.1186/s12929-019-0540-yZhao Z., Zheng C., Qi H., et al. Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and mouth disease in mainland China Lancet Reg Health West Pac. 2022. N 20. P. 100362.Zhao Z, Zheng C, Qi H, et al. Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and mouth disease in mainland China. Lancet Reg Health West Pac. 2022;20:100362. doi:10.1016/j.lanwpc.2021.100362Xie L., Huang R., Wang H., et al. Spatial-temporal heterogeneity and meteorological factors of hand-foot-and-mouth disease in Xinjiang, China from 2008 to 2016 PLoS One. 2021. Vol. 16. N 8. P. e0255222.Xie L, Huang R, Wang H, et al. Spatial-temporal heterogeneity and meteorological factors of hand-foot-and-mouth disease in Xinjiang, China from 2008 to 2016. PLoS One. 2021;16(8):e0255222. doi:10.1371/journal.pone.0255222Мартынова Г. П., Кутищева И. А., Бойцова Е. Б. и др. Энтеровирусная инфекция у детей: клинико-эпидемиологические особенности на современном этапе Детские инфекции. 2016. Т. 15. № 3. С. 15–18.Martynova GP, Kutishcheva IA, Boytsova EB, et  al. Enterovirus infection in  children: clinical and epidemiological features at the current stage.    Children Infections. 2016;15(3):15–18 (In Russ). https:doi.org/10.22627/2072-8107-2016-15-3-15-18Романенкова Н. И., Розаева Н. Р., Бичурина М. А. и др. Эпидемиологические аспекты энтеровирусной инфекции в Российской Федерации за период 2018– 2019 гг. Журнал инфектологии. 2021. Т. 13. № 1. С. 108–116.Romanenkova NI, Rozaeva NR, Bichurina MA, et al. Epidemiological aspects of enterovirus infection in the Russian Federation during the period of 2018–2019.  Journal Infectology. 2021;13(1):108–116 (In Russ). https:doi.org/10.22625/2072-6732-2021-13-1-108-116Thammasonthijarern N., Kosoltanapiwat N., Nuprasert W., et al. Molecular Epidemiological Study of Hand, Foot, and Mouth Disease in a Kindergarten-Based Setting in Bangkok, Thailand Pathogens. 2021. Vol. 10. N 5. P. 576Thammasonthijarern N, Kosoltanapiwat N, Nuprasert W, et al. Molecular Epidemiological Study of Hand, Foot, and Mouth Disease in a Kindergarten-Based Setting in Bangkok, Thailand. Pathogens. 2021;10(5):576. doi:10.3390/pathogens10050576Ding L., Zhang N., Zhu B., et al. Spatiotemporal characteristics and meteorological determinants of hand, foot and mouth disease in Shaanxi Province, China: a county-level analysis. BMC Public Health. 2021. Vol. 21. N 1. P. 374.Ding L, Zhang N, Zhu B, et al. Spatiotemporal characteristics and meteorological determinants of hand, foot and mouth disease in Shaanxi Province, China: a county-level analysis. BMC Public Health. 2021;21(1):374. doi:10.1186/s12889-021-10385-9Царькова С. А., Мороз Г. А., Бируля Н. И. Оценка возможности внедрения международного протокола по ведению детей с энтеровирусным везикулярным стоматитом на амбулаторном этапе оказания педиатрической помощи РМЖ. 2018. № 9. С. 17–19.Tsarkova SA, Moroz GA, Birulya NI. Assessment of the possibility of implementing the international protocol on the management of children with enterovirus vesicular stomatitis at the outpatient stage of pediatric care. RMZH. 2018;(9):17–19 (In Russ).Xu Y., Zheng Y., Shi W., et al. Pathogenic characteristics of hand, foot and mouth disease in Shaanxi Province, China, 2010-2016 Sci Rep. 2020. Vol. 10, N1. P. 989.Xu Y, Zheng Y, Shi W, et al. Pathogenic characteristics of hand, foot and mouth disease in Shaanxi Province, China, 2010-2016. Sci Rep. 2020;10(1):989. doi:10.1038/s41598-020-57807-zNguyet L.A., Thanh T.T., Nhan L.N.T., et al. Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease Emerg Infect Dis. 2020. Vol. 26, N 2. P. 298–306.Nguyet LA, Thanh TT, Nhan LNT, et al. Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease. Emerg Infect Dis. 2020;26(2):298–306. doi:10.3201/eid2602.190721Голицына Л. Н., Зверев В. В., Селиванова С. Г. и др. Этиологическая структура энтеровирусных инфекций в Российской Федерации в 2017–2018 гг. Здоровье населения и среда обитания. 2019. Т. 8, № 317. С. 30–38.Golitsyna LN, Zverev VV, Selivanova SG, et al. Etiological structure of enterovirus infections in the Russian Federation in 2017–2018. Zdorov’e naseleniya and sreda obitaniya. 2019;8(317):30–38 (In Russ). DOI: http:doi.org/10.35627/22195238/201931783038Akhmadishina L.V., Eremeeva T.P., Trotsenko O.E., et al. Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia PLoS One. 2014. Vol. 9, N 5. P. e97404.Akhmadishina LV, Eremeeva TP, Trotsenko OE, et al. Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. PLoS One. 2014;9(5):e97404. doi:10.1371/journal.pone.0097404Симованьян Э. Н., Денисенко В. Б., Бовтало Л. Ф. и др. Патология ЦНС у детей с энтеровирусной-71 инфекцией в эпидемический и межэпидемический периоды. Детские инфекции. 2015. Т. 14, № 3. С. 11–17.Simovanyan EN, Denisenko VB, Bovtalo LF, et al. CNS Pathology in Children with Enterovirus-71 Infection during Epidemic and Interepidemic Periods. Children infections. 2015;14(3):11–17 (In Russ). https:doi.org/10.22627/2072-8107-2015-14-3-11-17Романенкова Н. И., Бичурина М. А., Голицына Л. Н. и др. Неполиомиелитные энтеровирусы, обусловившие подъем заболеваемости энтеровирусной инфекцией на ряде территорий России в 2016 г. Журнал Инфектологии. 2017. Т. 9, № 3. С. 98–108.Romanenkova NI, Bichurina MA, Golitsyna LN et al. Nonpolio enteroviruses which caused the rise of enterovirus infection on some territories of Russia in 2016. Journal Infectology. 2017;9(3):98–108 (In Russ). https:doi.org/10.22625/2072-6732-2017-9-3-98-108Сапега Е. Ю., Бутакова Л. В., Троценко О. Е. и др. Современные молекулярно-генетические технологии в изучении интенсивности эпидемического процесса энтеровирусной инфекции в ряде субъектов Сибирского федерального округа Российской Федерации Здоровье населения и среда обитания. 2019. № 12. С. 42–50.Sapega EYu, Butakova LV, Trotsenko OE, et  al. State-of-the-art molecular genetic techniques in  surveillance over intensity of enterovirus infection epidemic process in some constituent entities of the Siberian Federal District of the Russian Federation.  Public Health and Life Environment – PH&LE. 2019;(12):42–50 (In Russ). https:doi. org/10.35627/2219-5238/2019-321-12-42-50Сапега Е. Ю., Бутакова Л. В., Троценко О. Е. и др. Особенности эпидемического процесса энтеровирусной инфекции в Сахалинской области на современном этапе Эпидемиология и Вакцинопрофилактика. 2019. Т.18, № 5. С. 33–41.Sapega EYu, Butakova LV, Trotsenko OE, et al. Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018).  Epidemiology and Vaccinal Prevention. 2019;18(5):33–41 (In Russ). https:doi.org/10.31631/2073-3046-2019-18-5-33-41Huang S.W., Cheng D., Wang J.R. Enterovirus A71: virulence, antigenicity, and genetic evolution over the years J Biomed Sci. 2019. Vol. 26, N 1. P. 81.Huang SW, Cheng D, Wang JR. Enterovirus A71: virulence, antigenicity, and genetic evolution over the years. J Biomed Sci. 2019;26(1):81. doi:10.1186/s12929-019-0574-1Puenpa J., Wanlapakorn N., Vongpunsawad S., et al. The History of Enterovirus A71 Outbreaks and Molecular Epidemiology in the Asia-Pacific Region J Biomed Sci. 2019. Vol. 26, N 1. P. 75.Puenpa J, Wanlapakorn N, Vongpunsawad S, et  al. The History of Enterovirus A71  Outbreaks and Molecular Epidemiology in  the Asia-Pacific Region. J Biomed Sci. 2019;26(1):75. doi:10.1186/s12929-019-0573-2Head J.R., Collender P.A., Lewnard JA, et al. Early Evidence of Inactivated Enterovirus 71 Vaccine Impact Against Hand, Foot, and Mouth Disease in a Major Center of Ongoing Transmission in China, 2011-2018: A Longitudinal Surveillance Study Clin Infect Dis. 2020. Vol. 71, N 12. P. 3088–3095.Head JR, Collender PA, Lewnard JA, et al. Early Evidence of Inactivated Enterovirus 71 Vaccine Impact Against Hand, Foot, and Mouth Disease in a Major Center of Ongoing Transmission in China, 2011–2018: A Longitudinal Surveillance Study. Clin Infect Dis. 2020;71(12):3088–3095. doi:10.1093/cid/ciz1188World Health Organization, Western Pacific Region [Internet]. Hand, Foot and Mouth Disease Situation Update 2018. Доступно на: https:iris.wpro.who.int/handle/10665.1/14191. Ссылка активна на 25 марта 2022.World Health Organization, Western Pacific Region [Internet]. Hand, Foot and Mouth  Disease  Situation  Update  2018. Available at: https:iris.wpro.who.int/handle/10665.1/14191. Accessed: 25 March 2022.Liu J., Xiang X., Pu Z., et al. Epidemic pattern of hand-foot-and-mouth disease in Xi’an, China from 2008 through 2015 BMC Infect Dis. 2019. Vol. 19, N 1. P. 19.Liu J, Xiang X, Pu Z, et al. Epidemic pattern of hand-foot-and-mouth disease in Xi’an, China from 2008 through 2015. BMC Infect Dis. 2019;19(1):19. doi:10.1186/s12879-018-3624-5Nhan L.N.T, Khanh T.H., Hong N.T.T., et al. Clinical, etiological and epidemiological investigations of hand, foot and mouth disease in southern Vietnam during 2015-2018 PLoS Negl Trop Dis. 2020. Vol. 14, N 8. P. e0008544.Nhan LNT, Khanh TH, Hong NTT, et al. Clinical, etiological and epidemiological investigations of hand, foot and mouth disease in southern Vietnam during 2015–2018. PLoS Negl Trop Dis. 2020;14(8):e0008544. doi:10.1371/journal.pntd.0008544Huang H., Deng L., Jia L., Zhu R. A clinical scoring system for pediatric hand-foot-mouth disease BMC Infect Dis. 2021. Vol. 21. N 1. P. 722.Huang H, Deng L, Jia L, Zhu R. A clinical scoring system for pediatric hand-foot-mouth disease. BMC Infect Dis. 2021;21(1):722. doi:10.1186/s12879-021-06424-wWang W., Song J., Wang J., et al. Cost-effectiveness of a national enterovirus 71 vaccination program in China PLoS Negl Trop Dis. 2017. Vol. 11, N 9. P. e0005899.Wang W, Song J, Wang J, et al. Cost-effectiveness of a national enterovirus 71 vaccination program in China. PLoS Negl Trop Dis. 2017;11(9):e0005899. doi:10.1371/journal.pntd.0005899A Guide to clinical management and public health response for hand, foot and mouth disease (HFMD) Regional Emerging Disease Intervention Center. ISBN 978 92 9061 525 5 (NLM Classification: WC 500) © World Health Organization 2011.A Guide to clinical management and public health response for hand, foot and mouth disease (HFMD) Regional Emerging Disease Intervention Center. ISBN 978 92 9061 525 5 (NLM Classification: WC 500) © World Health Organization 2011.Яговкин Э. А., Онищенко Г. Г., Попова А. Ю. и др. Состояние и перспективы разработки вакцин для специфической профилактики энтеровирусной (неполио) инфекции Эпидемиология и Вакцинопрофилактика. 2016. Т. 15, № 4. С. 74–82.Yagovkin EA, Onishchenko GG, Popova AYu, et al. Condition and Prospects of Development of Vaccines for Specific Prevention of Enterovirus (Nonpolio) Infection. Epidemiology and Vaccinal Prevention. 2016;15(4):74–82 (In Russ).  https:doi.org/10.31631/2073-3046-2016-15-4-74-82Li M.L., Shih S.R., Tolbert B.S., et al. Enterovirus A71 Vaccines Vaccines (Basel). 2021. Vol. 9, N 3. P. 199.Li ML, Shih SR, Tolbert BS, et al. Enterovirus A71 Vaccines. Vaccines (Basel). 2021;9(3):199. doi:10.3390/vaccines9030199Zhu F., Xu W., Xia J., et al. Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China N Engl J Med. 2014. Vol. 370, N 9. P. 818–28.Zhu F, Xu W, Xia J, et al. Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China. N Engl J Med. 2014;370(9):818-28. doi: 10.1056/NEJMoa1304923Hu Y., Zeng G., Chu K., et al. Five-year immunity persistence following immunization with inactivated enterovirus 71 type (EV71) vaccine in healthy children: A further observation Hum Vaccin Immunother. 2018. Vol. 14, N 6. P. 1517–1523.Hu Y, Zeng G, Chu K, et al. Five-year immunity persistence following immunization with inactivated enterovirus 71 type (EV71) vaccine in healthy children: A further observation. Hum Vaccin Immunother. 2018;14(6):1517–1523. doi:10.1080/21645515.2018.1442997Li R., Liu L., Mo Z., et al. An inactivated enterovirus 71 vaccine in healthy children N Engl J Med. 2014. Vol. 370, N 9. P. 829–37.Li R, Liu L, Mo Z, et al. An inactivated enterovirus 71 vaccine in healthy children. N Engl J Med. 2014;370(9):829–37. doi: 10.1056/NEJMoa1303224Wei M., Meng F., Wang S., et al. 2-Year Efficacy, Immunogenicity, and Safety of Vigoo Enterovirus 71 Vaccine in Healthy Chinese Children: A Randomized Open-Label Study J Infect Dis. 2017. Vol. 215, N 1. P. 56–63.Wei M, Meng F, Wang S, et al. 2-Year Efficacy, Immunogenicity, and Safety of Vigoo Enterovirus 71 Vaccine in Healthy Chinese Children: A Randomized Open-Label Study. J Infect Dis. 2017;215(1):56–63. doi: 10.1093/infdis/jiw502Du Z., Huang Y., Bloom M.S., et al. Assessing the vaccine effectiveness for hand, foot, and mouth disease in Guangzhou, China: a time-series analysis Hum Vaccin Immunother. 2021. Vol. 17, N 1. P. 217–223.Du Z, Huang Y, Bloom MS, et al. Assessing the vaccine effectiveness for hand, foot, and mouth disease in Guangzhou, China: a time-series analysis. Hum Vaccin Immunother. 2021;17(1):217–223. doi:10.1080/21645515.2020Yang T., Liu B., Yue L., et al. Preclinical safety assessment of a combined vaccine against Hepatitis a virus and enterovirus 71 Vaccine. 2021. Vol. 39, N 29. P. 3952–3963.Yang T, Liu B, Yue L, et al. Preclinical safety assessment of a combined vaccine against Hepatitis a virus and enterovirus 71. Vaccine. 2021;39(29):3952–3963. doi: 10.1016/j.vaccine.2021.05.058Yee P.T.I., Tan S.H., Ong K.C., et al. Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice Sci Rep. 2019. Vol. 9, N 1. P. 4805.Yee PTI, Tan SH, Ong KC, et al. Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice. Sci Rep. 2019;9(1):4805. doi:10.1038/s41598-019-41285-zYe L., Chen J., Fang T., et al. Vaccination coverage estimates and utilization patterns of inactivated enterovirus 71 vaccine post vaccine introduction in Ningbo, China BMC Public Health. 2021. Vol. 21, N 1. P. 1118Ye L, Chen J, Fang T, et al. Vaccination coverage estimates and utilization patterns of inactivated enterovirus 71 vaccine post vaccine introduction in Ningbo, China. BMC Public Health. 2021;21(1):1118. doi:10.1186/s12889-021-11198-6Wu Q., Zaid M., Xuan Z., et al. Changes in epidemiological features of vaccine preventable infectious diseases among three eras of national vaccination strategies from 1953 to 2018 in Shanghai, China Lancet Reg Health West Pac. 2021. N 7. P. 100092.Wu Q, Zaid M, Xuan Z, et al. Changes in epidemiological features of vaccine preventable infectious diseases among three eras of national vaccination strategies from 1953 to 2018 in Shanghai, China. Lancet Reg Health West Pac. 2021;7:100092. doi:10.1016/j.lanwpc.2021.100092

The authors declare that there are no conflicts of interest present.