References

epidemiology

Эпидемиология и Вакцинопрофилактика

Epidemiology and Vaccinal Prevention

2073-30462619-0494

«Numicom» LLC

10.31631/2073-3046-2016-15-3-72-82

epidemiology-168

Research Article

ВАКЦИНОПРОФИЛАКТИКА

VACCINAL PREVENTION

Факторы патогенности Staphylococcus aureus - их роль в инфекционном процессе и в формировании поствакцинального иммунитета

Staphylococcus aureus pathogenicity Factors and their Role in the Infection process and the induction of the postvaccination immunity

Грубер

И. М.

Gruber

I. M.

igruber_instmech@mail.ru

Егорова

Н. Б.

Egorova

N. B.

noemail@neicon.ru

Асташкина

Е. А.

Astashkina

E. A.

selena7-87@rambler.ru

ФГБНУ «Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова»РоссияFederal State Budgetary Research Institution «I.I. Mechnikov Sientific Research Institute for Vaccine and Sera»Russian Federation

2016

20062016

1537282

2016

Грубер И.М., Егорова Н.Б., Асташкина Е.А.

Gruber I.M., Egorova N.B., Astashkina E.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epidemvac.ru/jour/article/view/168

Бурное развитие молекулярно-биологических и генетических методов исследования способствовало расширению и углублению знаний о патогенезе инфекционных заболеваний, структуре факторов патогенности и их роли в развитии постинфекционного и поствакцинального иммунитета. В обзоре представлены данные литературы по этим вопросам применительно к заболеваниям, вызываемым S. aureus, которые приобрели большую социальную и экономическую значимость. Приведен перечень многочисленных факторов патогенности S. aureus, их значимость в развитии инфекционного процесса и возможность применения при создании вакцинных препаратов. Большая часть вакцин, в конструкции которых использованы капсульные полисахариды, токсины, белковые антигены клеточной стенки, находятся на различных стадиях доклинических и клинических испытаний. Предварительные данные свидетельствуют о необходимости использования для создания протективного иммунитета мультиантиген-ного комплекса с направленностью на многочисленные факторы патогенности S. aureus.

The rapid development of molecular-biological and genetic methods of research led to the broadening and deepening of knowledge of the pathogenesis of infection diseases, the structure of pathogenicity factors and their role in the development of the post-infection and post-vaccination immunity. In the review presented the literature data of this problem in relation to diseases, caused by S. aureus, which acquired great social and economic significance. Presented the list of numerous pathogenicity factors of S. aureus, their significance in the development of the infectious process and the results used to create vaccine preparations. Most of the vaccines in the construction of which used the capsular polysaccharides, toxins, protein antigens of the cell wall are in various stages of preclinical and clinical trials. Preliminary data indicate a need to use it to create protective immunity multiantigenic complex with focus on numerous factors of pathogenicity of S. aureus.

Staphylococcus aureusфакторы патогенностикапсульный полисахаридтоксинвакцинаинфекционный процесспоствакцинальный иммунитетэкспериментальные моделиStaphylococcus aureuspathogenicity factorscapsular polysaccharidetoxinvaccineinfection processpost-vaccination immunityexperimental models

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The authors declare that there are no conflicts of interest present.