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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2016-15-4-53-58</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-181</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФОРМАЦИЯ ВОЗ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>WHO INFORMATION</subject></subj-group></article-categories><title-group><article-title>Применение препаратов Имунофан, Полиоксидоний, Ронколейкин, Сальмозан и Фоспренил для потенцирования гуморального иммунного ответа у кроликов - продуцентов энтеровирусных диагностических сывороток</article-title><trans-title-group xml:lang="en"><trans-title>Application of Imunofan, Polioksidoniy, Ronkoleykin, Salmozan and Fosprenil for Stimulating the Humoral Immune Response in Rabbits Immunized against Enteroviruses</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>V. G.</given-names></name></name-alternatives><email xlink:type="simple">vgkozlov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хапчаев</surname><given-names>Ю. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Khapchaev</surname><given-names>Yu. Kh.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ишмухаметов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ishmukhametov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГУП «Предприятие по производству бактерийных и вирусных препаратов Института полиомиелита и вирусных энцефалитов им. М.П. Чумакова»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2016</year></pub-date><volume>15</volume><issue>4</issue><fpage>53</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козлов В.Г., Хапчаев Ю.Х., Ишмухаметов А.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Козлов В.Г., Хапчаев Ю.Х., Ишмухаметов А.А.</copyright-holder><copyright-holder xml:lang="en">Kozlov V.G., Khapchaev Y.K., Ishmukhametov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/181">https://www.epidemvac.ru/jour/article/view/181</self-uri><abstract><p>Экспериментально определена избирательная и непостоянная адъювантная активность препаратов Иммунофан, Полиоксидоний, Ронколейкин, Сальмозан и Фоспренил, примененных в качестве дополнительных стимуляторов иммунного ответа у кроликов - продуцентов поликлональных энтеровирусных диагностических сывороток для реакции нейтрализации.</p></abstract><trans-abstract xml:lang="en"><p>Enterprise of viral and bacterial Preparations of Chumakov Institute of poliomyelitis and viral encephalitides, Moscow Abstract Selective and inconstant adjuvant activities of the agents Imunofan, Polioksidoniy, Roncoleykin, Salmozan and Fosprenil were determined. Those agents were used as an additional stimulant of the immune response in rabbit immunized with enteroviruses to get the polyclonal diagnostic sera for neutralization.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кроличьи энтеровирусные нейтрализующие сыворотки</kwd><kwd>адъюванты</kwd><kwd>технология изготовления сывороток</kwd><kwd>enterovirus-neunralizing rabbit sera</kwd><kwd>adjuvants</kwd><kwd>sera production technology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Grandien M., Forsgren M., Ehrnst A. Enteroviruses. In: Diagnostic procedures for viral, rickettsial, and chlamydial infections. Eds.: Lennette E.H., Lennette D.A., Lennette E.T. Wachington, DC: American Public Health Assotiation. 1995: 279 - 297.</mixed-citation><mixed-citation xml:lang="en">Grandien M., Forsgren M., Ehrnst A. Enteroviruses. 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