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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2023-22-4-67-74</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-1854</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эпидемиологические особенности гнойного бактериального менингита в Российской Федерации на современном этапе</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiological Features of Purulent Bacterial Meningitis in the Russian Federation at the Present Stage</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2714-1191</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Koroleva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Александровна Королева – доктор медицинских наук, старший научный сотрудник лаборатории эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов</p><p>111123, Москва, ул. Новогиреевская, 3а</p></bio><bio xml:lang="en"><p>Maria A. Koroleva – Dr. Sci. (Med.), senior researcher at the laboratory of the epidemiology of meningococcal infection and bacterial meningitis</p><p>3a, st. Novogireevskaya, Moscow, 111123</p></bio><email xlink:type="simple">korolevamaria389@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6288-9074</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицай</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritsay</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Игоревна Грицай – кандидат медицинских наук, научный сотрудник лаборатории эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов</p><p>111123, Москва, ул. Новогиреевская, 3а</p></bio><bio xml:lang="en"><p>Maria I. Gritsay – Cand. Sci. (Med.), researcher at the laboratory of the epidemiology of meningococcal infection and bacterial meningitis</p><p>3a, st. Novogireevskaya, Moscow, 111123</p></bio><email xlink:type="simple">mariagriz@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5344-5829</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чурилова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Churilova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Надежда Сергеевна Чурилова – аспирант лаборатории эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов</p><p>111123, Москва, ул. Новогиреевская, 3а</p></bio><bio xml:lang="en"><p>Nadezda S. Churilova – graduate student at the laboratory of the epidemiology of meningococcal infection and bacterial meningitis</p><p>3a, st. Novogireevskaya, Moscow, 111123</p></bio><email xlink:type="simple">n27101996@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0578-146X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королева</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Koroleva</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Станиславовна Королева – доктор медицинских наук, заведующая лабораторией эпидемиологии менингококковой инфекции и бактериальных менингитов</p><p>111123, Москва, ул. Новогиреевская, 3а</p></bio><bio xml:lang="en"><p>Irina S. Koroleva – Dr. Sci. (Med.), Head of the Laboratory epidemiology of meningococcal infection and bacterial meningitis</p><p>3a, st. Novogireevskaya, Moscow, 111123</p></bio><email xlink:type="simple">irina-korol@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>09</month><year>2023</year></pub-date><volume>22</volume><issue>4</issue><fpage>67</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Королева М.А., Грицай М.И., Чурилова Н.С., Королева И.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Королева М.А., Грицай М.И., Чурилова Н.С., Королева И.С.</copyright-holder><copyright-holder xml:lang="en">Koroleva M.A., Gritsay M.I., Churilova N.S., Koroleva I.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/1854">https://www.epidemvac.ru/jour/article/view/1854</self-uri><abstract><sec><title> </title><p> </p></sec><sec><title>Введение</title><p>Введение. Снижение числа случаев инвазивных заболеваний, вызванных менингококком (Neisseria meningitidis, N. meningitidis), пневмококком (Streptococcus pneumoniae, S. pneumoniae), гемофильной палочкой (Haemophilus influenzae, H. influenzae) в мире было связано с мерами, направленными против распространения коронавирусной болезни 2019 г. (COVID-19).</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Представление эпидемиологических особенностей гнойного бактериального менингита (ГБМ) в Российской Федерации (РФ) на современном этапе.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. На базе Российского Референс-центра по мониторингу за бактериальными менингитами (РЦБМ) налажена углублённая персонифицированная система учёта случаев ГБМ. С 2010 г. в систему мониторирования включены все территории РФ. За 2022 г. в РЦБМ поступила информация о 1596 случаях ГБМ. В работе использован описательно-оценочный эпидемиологический метод: ретроспективный анализ.</p></sec><sec><title>Результаты</title><p>Результаты. Начавшийся в 2017 г. рост заболеваемости генерализованной формой менингококковой инфекции (ГФМИ) фиксировался в 2018 г. и 2019 г., однако в 2020–2021 гг. рост был прерван: показатель резко снизился, составив 0,26–0,21 на 100 тыс. населения, что, по всей вероятности, связано с разобщением населения в результате мероприятий, направленных на борьбу с новой коронавирусной инфекцией. Меры борьбы с COVID-19 были отменены в 2021 г., и уже в 2022 г. показатель заболеваемости ГБМ увеличился в 1,4 раза, при этом ГФМИ – в 2 раза, составив 0,44 на 100 тыс. населения. Резкое снижение заболеваемости ГБМ, вызванных пневмококком и гемофильной палочкой, в 2020–2021 гг. сменилось в 2022 г. ростом показателя заболеваемости пневмококковым менингитом, однако заболеваемость менингитом, вызванным гемофильной палочкой, осталась на прежнем уровне.</p></sec><sec><title>Заключение</title><p>Заключение. Продолжение мониторинга заболеваемости ГБМ и свойств возбудителя является чрезвычайно важной задачей в целях выявления групп и территорий риска для своевременной оптимизации профилактических мер, включая вакцинопрофилактику, признанную наиболее эффективной в борьбе с менингококковой, пневмококковой и гемофильной типа b инфекциями, в основном обуславливающими бактериальный менингит. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. The decrease in the number of cases of invasive diseases caused by N. meningitidis, S. pneumoniae, H. influenzae and in the world has been associated with measures against the spread of the 2019 coronavirus disease (COVID-19).</p></sec><sec><title>Aim</title><p>Aim. Presentation of the epidemiological features of purulent bacterial meningitis (PBM) in the Russian Federation at the present stage.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. On the basis of the Russian Reference Center for Monitoring Bacterial Meningitis (RCMC), an in-depth personalized system for recording PBM cases has been established. Since 2010, all territories of the Russian Federation have been included in the monitoring system. In 2022, the RCMC received information on 1596 cases of PBM. The descriptive-evaluative epidemiological method was used in the work: a retrospective analysis.</p></sec><sec><title>Results</title><p>Results. The increase in the incidence of a generalized form of meningococcal infection (GFMI), which began in 2017, was recorded in 2018 and 2019, but in 2020–2021 growth was interrupted: the indicator dropped sharply, amounting to 0.26–0.21 per 100 thousand of the population, which is most likely due to the disunity of the population as a result of measures aimed at combating the new coronavirus infection. Measures to combat COVID-19 were canceled in 2021, and already in 2022 the incidence rate of GBM increased by 1.4 times, while the GFMI by 2 times, amounting to 0.44 per 100 thousand of the population. A sharp decrease in the incidence of PBM caused by S. pneumoniae and H. influenzae in 2020-2021 was replaced in 2022 by an increase in the incidence of pneumococcal meningitis, however, the incidence of meningitis caused by H. influenzae remained at the same level.</p></sec><sec><title>Conclusion</title><p>Conclusion. Continued monitoring of the incidence of PBM and the properties of the pathogen are extremely important tasks in order to identify risk groups and areas for the timely optimization of vaccination measures, given that the three infections that cause bacterial meningitis are vaccine-controlled, and vaccination is recognized as the most effective measure to combat meningococcal, pneumococcal and hemophilic infections.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>бактериальный менингит</kwd><kwd>менингококковая инфекция</kwd><kwd>менингококк</kwd><kwd>пневмококк</kwd><kwd>гемофильная палочка</kwd><kwd>эпидемиология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bacterial meningitis</kwd><kwd>meningococcal infection</kwd><kwd>Neisseria meningitidis</kwd><kwd>Streptococcus pneumoniae</kwd><kwd>Haemophilus influenzae</kwd><kwd>epidemiology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alderson, MR, Arkwright PD, Bai X, et al. 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