<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2023-22-5-40-47</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-1876</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Злокачественные новообразования репродуктивных органов как причина смерти молодого населения в Российской Федерации</article-title><trans-title-group xml:lang="en"><trans-title>Malignant Neoplasms of the Reproductive Organs as a Cause of Death of the Young Population in the Russian Federation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4925-5421</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдина</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudina</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктория Сергеевна Юдина – аспирант кафедры эпидемиологии и доказательной медицины</p><p>+7 (985) 425-64-43</p></bio><bio xml:lang="en"><p>Viktoria S. Yudina – Postgraduate Student, Department of Epidemiology and Evidence-Based Medicine</p><p>+7 (985) 425-64-43</p></bio><email xlink:type="simple">viktoriayudina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>10</day><month>11</month><year>2023</year></pub-date><volume>22</volume><issue>5</issue><fpage>40</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юдина В.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Юдина В.С.</copyright-holder><copyright-holder xml:lang="en">Yudina V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/1876">https://www.epidemvac.ru/jour/article/view/1876</self-uri><abstract><p>Актуальность. Демографическая ситуация в Российской Федерации на протяжении последних десятилетий характеризуется отрицательной динамикой, при этом два ключевых показателя, соотношение которых влияет на это, – рождаемость и смертность. Особый интерес в данном ключе представляют злокачественные новообразования (ЗНО) органов репродуктивной системы, которые могут влиять как на снижение рождаемости, особенно если речь заходит о возрастной группе до 40 лет, так и вносить существенный вклад в структуру смертности населения. Цель. Анализ динамики и структуры смертности от ЗНО репродуктивных органов среди населения в возрасте от 15 до 39 лет в Российской Федерации за 2011–2020 гг. Материалы и методы. Проанализированы данные форм федерального государственного статического наблюдения по распределению умерших по полу, возрастным группам и причинам смерти Росстата (ФСН-С51) и статистические сведения по половозрастному составу населения территорий РФ. Результаты. Наибольшие «грубые» показатели смертности были отмечены в Сибирском и Дальневосточном федеральных округах (5,04 (95% ДИ = 4,49 – 5,58) и 5,00 (95% ДИ = 4,09 – 5,90) на 100 тыс. населения соответственно), наименьшие – в регионах Северо-Кавказского федерального округа (2,58 (95% ДИ = 2,06 – 3,11) на 100 тыс. населения). Также выявлены существенные гендерные различия. Смертность женщин от ЗНО репродуктивных органов была значительно выше («грубый» показатель смертности среди женщин составил 7,57 (95% ДИ = 7,22 – 7,92) против 0,72 (95% ДИ = 0,61 – 0,82) у мужчин на 100 тыс.) за счет доминирования онкологических поражений шейки матки и молочной железы в более раннем возрасте. Выводы. Выявлено отсутствие положительных тенденций в сокращении смертности от ЗНО репродуктивных органов среди молодого населения Российской Федерации, наиболее неблагополучны ДВФО и СФО. Преобладание женщин в общей структуре смертности объясняется доминированием онкологических поражений шейки матки и молочной железы в более раннем возрасте.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. The demographic situation in the Russian Federation over the past decades has been characterized by negative dynamics, while the two key indicators, the ratio of which affects this, are birth and death rates. Of particular interest in this case are malignant neoplasms (MNs) of the organs of the reproductive system, which can both affect the decline in fertility, especially when it comes to the age group under 40, and make a significant contribution to the structure of the population mortality. Аim. Analyze the changes in mortality rates from cancer of the reproductive organs among the population aged 15 to 39 years, their dynamics and structure in the Russian Federation for 2011–2020. Materials and methods. To calculate the indicators, an analysis was carried out of the data of the forms of the federal state static observation on the distribution of the deceased by sex, age groups and causes of death by Rosstat (FSN-C51) and statistical information on the age and sex composition of the population of the territories of the Russian Federation. Results. The highest «crude» mortality rates were noted in the Siberian and Far Eastern Federal Districts (5.04 (95% CI = 4.49–5.58) and 5.00 (95% CI = 4.09–5.90) per 100 thousand of the population, respectively), the smallest – n the regions of the North Caucasus Federal District (2.58 (95% CI = 2.06 - 3.11) per 100 thousand of the population). Significant gender differences were also identified. Female mortality from malignancies of the reproductive organs was significantly higher (the "crude” mortality rate among women was found to be 7.57 (95% CI = 7.22–7.92) versus 0.72 (95% CI = 0.61–0.82) among men per 100 thousand) due to the dominance of oncological lesions of the cervix and mammary gland at an earlier age. Conclusion. The identified features of the manifestations of mortality from cancer of the reproductive organs for various territories and population groups can serve as a rationale for strengthening the existing preventive measures, such as vaccination against HPV, as well as for developing new strategies aimed at improving the demographic situation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>злокачественные новообразования</kwd><kwd>репродуктивное здоровье</kwd><kwd>подростки и молодые люди</kwd><kwd>смертность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>malignant neoplasms</kwd><kwd>reproductive health</kwd><kwd>adolescents and young people</kwd><kwd>mortality rates</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кадыров З. А., Фаниев М. В., Прокопьев Я. В. и др. Репродуктивное здоровье населения России как ключевой фактор демографической динамики // Вестник современной клинической медицины. 2022. Т.15, №5. С.100–106</mixed-citation><mixed-citation xml:lang="en">Kadyrov ZA, Faniev MV, Prokopiev YV, et al. Reproductive health of the Russian population as a key factor of demographic dynamics. The Bulletin of Contemporary Clinical Medicine.2022;15(5):100–106 (In Russ). doi: 10.20969/VSKM.2022.15(5).100-106.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Семенова И. Н., Рафикова Ю. С. Оценка показателей репродуктивного здоровья населения Зауралья Республики Башкортостан в 2000–2020 гг. // Экология человека. 2022. Т. 29, №11. С. 771–781.</mixed-citation><mixed-citation xml:lang="en">Semenova IN, Rafikova YS. Assessment of indicators of reproductive health of the population of the Trans-Ural Republic of Bashkortostan in 2000–2020. Ekologiya cheloveka (Human Ecology).2022;29(11):771–781. (In Russ). doi: https://doi.org/10.17816/humeco105718</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Foreman KJ., Marquez N., Dolgert A., et al. Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories // Lancet. 2018. Vol. 392, N10159. P. 2052–2090.</mixed-citation><mixed-citation xml:lang="en">Foreman KJ, Marquez N, Dolgert A, et al. Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories. Lancet. 2018;392(10159):2052–2090. doi: 10.1016/S0140-6736(18)31694-5</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bray F., Jemal A., Grey N., Ferlay J., et al. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study // Lancet Oncol. 2012. Vol. 13, N8. P. 790–801.</mixed-citation><mixed-citation xml:lang="en">Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol. 2012;13(8):790–801. doi: 10.1016/S1470-2045(12)70211-5</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sung H., Ferlay J., Siegel RL., et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021. Vol.71, N3. P. 209–249.</mixed-citation><mixed-citation xml:lang="en">Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Global Burden of Disease 2019 Cancer Collaboration; Kocarnik JM., Compton K., Dean FE., et.al. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2022. Vol. 8, N3. P. 420–444.</mixed-citation><mixed-citation xml:lang="en">Global Burden of Disease 2019 Cancer Collaboration; Kocarnik JM, Compton K, Dean FE, et.al. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2022;8(3):420–444. doi: 10.1001/jamaoncol.2021.6987</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2021 г.у (заболеваемость и смертность). Каприн А. Д., Старинский В. В., Петрова Г. В., ред. М.: МНИОИ им. П.А. Герцена, филиал ФГБУ «НМИЦ радиологии» Минздрава России; 2022.</mixed-citation><mixed-citation xml:lang="en">Kaprin AD, Starinsky VV, Petrova GV, editors. Zlokachestvennyye novoobrazovaniya v Rossii v 2021 godu (zabolevayemost’ i smertnost’). Moscow: MNIOI im. P.A. Gertsena, filial FGBU «NMITS radiologii» Minzdrava Rossii; 2022. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">van der Meer DJ., Karim-Kos HE., van der Mark M., et al. Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15-39 Years): A Population-Based Study in The Netherlands 1990-2016 // Cancers (Basel). 2020. Vol. 12, N11. P. 3421.</mixed-citation><mixed-citation xml:lang="en">van der Meer DJ, Karim-Kos HE, van der Mark M, et al. Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15-39 Years): A Population-Based Study in The Netherlands 1990–2016. Cancers (Basel). 2020;12(11):3421. doi: 10.3390/cancers12113421.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Юдина В. С., Лопухов П. Д., Каприн А. Д. и др. Проявления заболеваемости злокачественными новообразованиями органов репродуктивной системы у молодого населения Российской Федерации: региональные особенности. Сибирский научный медицинский журнал. 2023. Т.43, №3. С. 113–120.</mixed-citation><mixed-citation xml:lang="en">Yudina VS, Lopukhov PD, Kaprin AD, et al. Manifestations of the incidence of malignant neoplasms of the reproductive system in the young population of Russian Federation: regional features. Siberian scientific medical journal.2023;43(3):113–120 (In Russ.). doi:10.18699/SSMJ20230314</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Юдина В. С., Лопухов П. Д., Трушина О. И. и др. Эпидемиологическая характеристика злокачественных новообразований органов репродуктивной системы у лиц в возрасте от 15 до 39 лет в Российской Федерации. Эпидемиология и инфекционные болезни. Актуальные вопросы. 2023. Т.13, №1. С.25–31.</mixed-citation><mixed-citation xml:lang="en">Yudina VS, Lopukhov PD, Trushina OI, et al. Epidemiologicheskaya kharakteristika zlokachestvennykh novoobrazovaniy organov reproduktivnoy sistemy u lits v vozraste ot 15 do 39 let v Rossiyskoy Federatsii. Epidemiologiya i infektsionnyye bolezni. Aktual’nyye voprosy. 2023;13(1):25–31. (In Russ). doi:10.18565/epidem.2023.13.1</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Trama A., Stark D., Bozovic-Spasojevic I., et al. Cancer burden in adolescents and young adults in Europe // ESMO Open. 2023. Vol.1, 100744.</mixed-citation><mixed-citation xml:lang="en">Trama A, Stark D, Bozovic-Spasojevic I, et al. Cancer burden in adolescents and young adults in Europe. ESMO Open. 2023;1:100744. doi: 10.1016/j.esmoop.2022.100744</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ardekani A., Sepidarkish M., Mollalo A., et al. Worldwide prevalence of human papillomavirus among pregnant women: A systematic review and meta-analysis. Rev Med Virol. 2023. Vol. 1. 2374.</mixed-citation><mixed-citation xml:lang="en">Ardekani A, Sepidarkish M, Mollalo A, et al. Worldwide prevalence of human papillomavirus among pregnant women: A systematic review and meta-analysis. Rev Med Virol. 2023:1:2374. doi: 10.1002/rmv.2374</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lechner M., Vassie C., Kavasogullari C., et al. A cross-sectional survey of awareness of human papillomavirus-associated oropharyngeal cancers among general practitioners in the UK // BMJ Open. 2018. Vol. 8, N7. e023339.</mixed-citation><mixed-citation xml:lang="en">Lechner M, Vassie C, Kavasogullari C, et al. A cross-sectional survey of awareness of human papillomavirus-associated oropharyngeal cancers among general practitioners in the UK. BMJ Open. 2018;8(7):e023339. doi: 10.1136/bmjopen-2018-023339</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Stoneham S., Murray M., Thomas B., et al. AYA testis cancer: The unmet challenge. Pediatr Blood Cancer. 2019. Vol. 66, N8., e27796.</mixed-citation><mixed-citation xml:lang="en">Stoneham S, Murray M, Thomas B, et al. AYA testis cancer: The unmet challenge. Pediatr Blood Cancer. 2019;66(8):e27796. doi: 10.1002/pbc.27796</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kusler KA., Poynter JN. International testicular cancer incidence rates in children, adolescents and young adults. Cancer Epidemiol. 2018. Vol. 56, P. 106–111.</mixed-citation><mixed-citation xml:lang="en">Kusler KA, Poynter JN. International testicular cancer incidence rates in children, adolescents and young adults. Cancer Epidemiol. 2018;56:106–111. doi: 10.1016/j.canep.2018.08.002</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Laguna MP., Pizzocaro G., Klepp O., et al. EAU guidelines on testicular cancer. Eur Urol. 2001. Vol. 40, N2. P. 102–110.</mixed-citation><mixed-citation xml:lang="en">Laguna MP, Pizzocaro G, Klepp O, et al. EAU guidelines on testicular cancer. Eur Urol. 2001;40(2):102–110. doi:10.1159/000049759</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chong RIH., Leow JJ., Choo ZW., Salada R., et al. Testicular self-examination for early detection of testicular cancer // World J Urol. 2023. Vol. 41, N4. P. 941–951.</mixed-citation><mixed-citation xml:lang="en">Chong RIH, Leow JJ, Choo ZW, et al. Testicular self-examination for early detection of testicular cancer. World J Urol. 2023;41(4):941–951. doi: 10.1007/s00345-023-04381-4</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
