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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2023-22-6-54-65</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-1905</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эпидемический процесс COVID­19 в учреждениях долговременного ухода Москвы</article-title><trans-title-group xml:lang="en"><trans-title>The COVID-19 Epidemic Process in Long-Term Care Facilities in Moscow</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4429-9844</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давидова</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Davidova</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Георгиевна Давидова – аспирант</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia G. Davidova – postgraduate student</p><p>Moscow</p></bio><email xlink:type="simple">dawidowa.nat2016@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1322-0155</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Углева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ugleva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Викторовна Углева – д. м. н., доцент, консультант организационно-методического отдела административно-управленческого подразделения</p><p>+7 (905) 360-87-77</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana V. Ugleva – Dr. Sci. (Med.), Assoc. Prof., consultant, Organizational and methodological department, Administrative division</p><p>+7 (905) 360-87-77</p><p>Moscow</p></bio><email xlink:type="simple">uglevas@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7102-5414</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабалина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabalina</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Васильевна Шабалина – д. м. н., профессор, ведущий научный сотрудник</p><p>+7 (906) 743-48-64</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana V. Shabalina – Dr. Sci. (Med.), Professor</p><p>+7 (906) 743-48-64</p><p>Moscow</p></bio><email xlink:type="simple">svs2810@pcr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>05</day><month>01</month><year>2024</year></pub-date><volume>22</volume><issue>6</issue><fpage>54</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Давидова Н.Г., Углева С.В., Шабалина С.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Давидова Н.Г., Углева С.В., Шабалина С.В.</copyright-holder><copyright-holder xml:lang="en">Davidova N.G., Ugleva S.V., Shabalina S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/1905">https://www.epidemvac.ru/jour/article/view/1905</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. COVID-19 остается актуальным заболеванием для закрытых учреждений долговременного ухода (ЗУДУ), так как локальные вспышки COVID-19 продолжают регистрироваться в 2022 г. и в 2023 г.</p></sec><sec><title>Цель</title><p>Цель. Изучение эпидемического процесса COVID-19 в 2020–2022 гг. в ЗУДУ (домов престарелых, психоневрологических интернатов), расположенных на территории Москвы.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Анализ эпидемического процесса COVID-19 в учреждениях долговременного ухода проводился за период 2020–2022 гг. Использовались данные АИС «ОРУИБ» о 5390 заболевших COVID-19 жителей и сотрудников 28 учреждений Москвы и 3 239 617 жителей Москвы; 15 актов эпидемиологического расследования очага инфекционной болезни за трехлетний период (с 2020 г. по 2022 г.).</p></sec><sec><title>Результаты</title><p>Результаты. Всего в ЗУДУ было зарегистрировано 9 подъемов заболеваемости COVID-19. Первый подъем был самым интенсивным, что отразилось на заболеваемости (81,14 на 1000 коек за неделю), на показателях активности эпидемических очагов (КО – 100%, ИО – 21,08, R – 20,08), смертности (2020 г. – 32,6%). В первый подъем заболеваемости в домах престарелых отмечалась прямая корреляционная связь высокой силы с заболеваемостью населения Москвы (r = 0,906), а за последующие подъемы заметная связь (r = 0,580) при р &lt; 0,05. С 2-го по 9-й подъемы заболеваемость имела тенденцию к снижению. Все подъемы COVID-19 происходили за счет формирования очагов в учреждениях, где источником инфекции являлись сотрудники. На 2020–2022 гг. среди жителей удельный вес тяжелых случаев инфекции с летальным исходом колебался от 14,6 ± 6,7% до 31,8 ± 6,5%.</p></sec><sec><title>Заключение</title><p>Заключение. Анализ проявлений эпидемического процесса COVID-19 в учреждениях долговременного ухода Москвы за 2020–2022 гг. позволил выделить два этапа заболеваемости.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. COVID-19 remains an urgent disease for long-term care institutions (LTCI), because local outbreaks of COVID-19 continue to be registered in 2022 and in 2023.</p></sec><sec><title>Aims</title><p>Aims. To study the epidemic process of COVID-19 in LTCI (nursing homes, neuropsychiatric boarding schools) in Moscow for 2020–2022.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The analysis of the epidemic process of COVID-19 in LTCI was carried out for the period 2020–2022. Data of Automatic information system «Department of Registration and Accounting of Infectious Diseases was used: 5390 COVID-19 residents and employees of 28 institutions in Moscow and 3,239,617 residents of Moscow; 15 acts of epidemiological investigation of the focus of infectious disease in the period from 2020 to 2022.</p></sec><sec><title>Results</title><p>Results. In total, 9 increases in the incidence of COVID-19 were registered. The first rise was the most intense, which affected morbidity (81.14 per 1,000 beds per week), indicators of activity of epidemic foci (KO – 100%, IO – 21.08, R – 20.08), mortality (for 2020 – 32.6%). In the first rise of morbidity in nursing homes, there is a direct correlation of a high degree of connection with the morbidity of the population of Moscow (r = 0.906), and for subsequent rises there is a noticeable relationship (r = 0.580) at p&lt;0.05. From 2 to 9 rises, the incidence tended to decrease. All the rises of COVID-19 occurred due to the formation of foci in institutions where the source of infection was employees. For 2020–2022, the proportion of severe cases of infection with a fatal outcome among residents ranged from 14.6 ±6.7% to 31.8 ± 6.5%.</p></sec><sec><title>Conclusion</title><p>Conclusion. The analysis of the manifestations of the COVID-19 epidemic process in long-term care institutions in Moscow for 2020–2022 allowed us to distinguish two stages of morbidity.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>очаговая заболеваемость</kwd><kwd>долговременный уход</kwd><kwd>дома престарелых</kwd><kwd>пожилые люди</kwd><kwd>интернаты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>outbreak morbidity</kwd><kwd>long-term care</kwd><kwd>nursing homes</kwd><kwd>elderly people</kwd><kwd>boarding schools</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Suetens, C., Latour, K., Kärki, T., et al. Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017. Eurosurveillance. 2018. Vol. 23. №. 46. P. 1800516.</mixed-citation><mixed-citation xml:lang="en">Suetens, C., Latour, K., Kärki, T., et al. Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017. Eurosurveillance. 2018; 23(46): 1800516. https: doi.org/10.2807/1560-7917.ES.2018.23.46.1800516</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Thigpen, M. C., Richards Jr, C. L., Lynfield, R., et al. Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998–2003. Emerging Infectious Diseases. 2007. Vol. 13. №. 12. P. 1852.</mixed-citation><mixed-citation xml:lang="en">Thigpen, M. C., Richards Jr, C. L., Lynfield, R., et al. Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998–2003. Emerging Infectious Diseases. 2007; 13(12): 1852. doi: 10.3201/eid1312.070303</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Barret, A. S., Jourdan-da Silva, N., Ambert-Balay, K., et al. Surveillance for outbreaks of gastroenteritis in elderly long-term care facilities in France, November 2010 to May 2012. Eurosurveillance. 2014. Vol. 19. №. 29.</mixed-citation><mixed-citation xml:lang="en">Barret, A. S., Jourdan-da Silva, N., Ambert-Balay, K., et al. Surveillance for outbreaks of gastroenteritis in elderly long-term care facilities in France, November 2010 to May 2012. Eurosurveillance. 2014; 19(29). http: www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20859</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Arons, M. M., Hatfield, K. M., Reddy, et al. Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. New England journal of medicine. 2020. Vol. 382. №. 22. P. 2081–2090.</mixed-citation><mixed-citation xml:lang="en">Arons, M. M., Hatfield, K. M., Reddy, S. C., et al. Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. New England journal of medicine. 2020; 382(22): 2081–2090. DOI: 10.1056/NEJMoa2008457</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Klein, A., Edler, C., Fitzek, A., et al. Der erste COVID-19-Hotspot in einer Hamburger Senioreneinrichtung: Präventionskonzept, Letalität und Obduktionsbefunde. Rechtsmedizin (Berlin, Germany). 2020. Vol. 30. №. 5. P. 325.</mixed-citation><mixed-citation xml:lang="en">Klein, A., Edler, C., Fitzek, A., et al. Der erste COVID-19-Hotspot in einer Hamburger Senioreneinrichtung: Präventionskonzept, Letalität und Obduktionsbefunde. Rechtsmedizin (Berlin, Germany). 2020; 30(5): 325. https: doi.org/10.1007/s00194-020-00404-1</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Couderc, A. L., Correard, F., Hamidou, Z., et al. Factors associated with COVID-19 hospitalizations and deaths in French nursing homes. Journal of the American Medical Directors Association. 2021. Vol. 22. №. 8. P. 1581–1587. e3.</mixed-citation><mixed-citation xml:lang="en">Couderc, A. L., Correard, F., Hamidou, Z., et al. Factors associated with COVID-19 hospitalizations and deaths in French nursing homes. Journal of the American Medical Directors Association. 2021; 22(8): 1581–1587. https: doi.org/10.1016/j.jamda.2021.06.023</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">McMichael, T. M., Currie, D. W., Clark, S., et al. Epidemiology of COVID-19 in a long-term care facility in King County, Washington. New England Journal of Medicine. 2020. Vol. 382. №. 21. P. 2005–2011.</mixed-citation><mixed-citation xml:lang="en">McMichael, T. M., Currie, D. W., Clark, S., et al. Epidemiology of COVID-19 in a long-term care facility in King County, Washington. New England Journal of Medicine. 2020; 382(21): 2005–2011. DOI: 10.1056/NEJMoa2005412</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Севастьянов, М. А., Божков, И. А., Лучкевич, В. С., и др. Эпидемиология и профилактика коронавирусной инфекции в учреждениях долговременного ухода.</mixed-citation><mixed-citation xml:lang="en">Sevastianov MA, Bozhkov IA, Luchkevich VS, et al. Epidemiology and prevention of coronavirus infection in long-term care facilities. Herald of North-Western State Medical University named after I.I. Mechnikov. 2020;12(4):39–46.(InRuss.) https: doi.org/10.17816/mechnikov44741</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Вестник Северо-Западного государственного медицинского университета им. ИИ Мечникова. 2020. Т. 12. № 4. С. 39–46.</mixed-citation><mixed-citation xml:lang="en">Davidova NG, Ugleva SV, Akimkin VG. Overview of the epidemiological situation and risk factors for severe COVID-19 in long-term care facilities in the world and Russia. Zdorov’e Naseleniya i Sreda Obitaniya. 2023;31(2): 64–74. (In Russ.) doi: https: doi.org/10.35627/2219-5238/2023-31-2-Х-Х</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Давидова, Н. Г., Углева, С. В., Акимкин, В. Г. Обзор эпидемиологической ситуации и факторов риска тяжелого течения COVID-19 в закрытых учреждениях долговременного ухода в мире и России. Здоровье населения и среда обитания–ЗНиСО, 2023. Т. 31. №2. С. 64–74.</mixed-citation><mixed-citation xml:lang="en">Teslova O.E., Kanishcheva N.E. A new coronavirus infection in the Rostov region. [Abstract]. In: Modern problems of epidemiology, microbiology and hygiene: Materials of the XII All-Russian Scientific and Practical Conference of Young Scientists and specialists of Rospotrebnadzor Rostov-on-Don, October 21-22, 2020: 90–92. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Теслова О.Е., Канешова Н.Е. Новая коронавирусная инфекция в Ростовской области. В сб.: Современные проблемы эпидемиологии, микробиологии и гигиены: Материалы XII Всероссийской научно-практической конференции молодых ученых и специалистов Роспотребнадзора Ростов-на-Дону, 21–22 октября 2020 г. С. 90–92.</mixed-citation><mixed-citation xml:lang="en">Kareva, D., Sinyavskaya, O., &amp; Sharepina, E. Models of adaptation of inpatient social service institutions to the coronavirus pandemic. The Journal of Social Policy Studies. 2023; 21(1), 61–78. https: doi.org/10.17323/727-0634-2023-21-1-61-78</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Карева, Д., Синявская, О., Шарепина, Е. Модели адаптации стационарных учреждений социального обслуживания к пандемии коронавируса. Журнал исследований социальной политики. 2023. Т. 21 №1. С. 61–78.</mixed-citation><mixed-citation xml:lang="en">Andrew, M., Searle, S. D., McElhaney, et al. COVID-19, frailty and long-term care: Implications for policy and practice. The Journal of Infection in Developing Countries. 2020; 14(05), 428–432. doi: 10.3855/jidc.13003</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Andrew, M., Searle, S. D., McElhaney, et al. COVID-19, frailty and long-term care: Implications for policy and practice. The Journal of Infection in Developing Countries. 2020. T. 14 № 05. P. 428–432.</mixed-citation><mixed-citation xml:lang="en">Federal State Statistics Service. Table «Stacionarnye organizacii social’nogo obsluzhivanija dlja grazhdan pozhilogo vozrasta i invalidov (vzroslyh)». [Internet]. Available at: https: rosstat.gov.ru/storage/mediabank/soc1.xlsx Accessed: 23.08.2023г.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральная служба государственной статистики. Таблица «Стационарные организации социального обслуживания для граждан пожилого возраста и инвалидов (взрослых)» [Электронный ресурс] Доступно по: https: rosstat.gov.ru/storage/mediabank/soc1.xlsx Ссылка активна на 23.08.2023г.</mixed-citation><mixed-citation xml:lang="en">Akimkin V.G., Popova A.Yu., Ploskireva A.A., et al. COVID-19: the evolution of the pandemic in Russia. Report I: manifestations of the COVID-19 epidemic process. Journal of microbiology, epidemiology and immunobiology = Zhurnal mikrobiologii, èpidemiologii i immunobiologii. 2022;99(3):269–286. (In Russ.) DOI: https: doi.org/10.36233/0372-9311-276</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Акимкин В.Г., Попова А.Ю., Плоскирева А.А., и др. COVID-19: эволюция пандемии в России. Сообщение I: проявления эпидемического процесса COVID-19. Журнал микробиологии, эпидемиологии и иммунобиологии. 2022. Т. 99 №3. С. 269–286.</mixed-citation><mixed-citation xml:lang="en">Akimkin V.G., Popova A.Yu., Khafizov K.F., et al. COVID-19: evolution of the pandemic in Russia. Report II: dynamics of the circulation of SARS-CoV-2 genetic variants. Journal of microbiology, epidemiology and immunobiology = Zhurnal mikrobiologii, èpidemiologii i immunobiologii. 2022;99(4):381–396. (In Russ.) DOI: https: doi.org/10.36233/0372-9311-295</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Акимкин В.Г., Попова А.Ю., Хафизов К.Ф., и др. COVID-19: эволюция пандемии в России. Сообщение II: динамика циркуляции геновариантов вируса SARS-CoV-2. Журнал микробиологии, эпидемиологии и иммунобиологии. 2022. Т. 99. №4. С. 381–396.</mixed-citation><mixed-citation xml:lang="en">N.Yu.Pshenichnaya. COVID-19 EPIDEMIC PROCESS IN THE RUSSIAN FEDERATION: INTERIM RESULTS. 1th REPORT. 2020. (In Russ.) DOI:10.21055/preprints-3111725</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Пшеничная Н. Ю. ЭПИДЕМИЧЕСКИЙ ПРОЦЕСС COVID-19 В РОССИЙСКОЙ ФЕДЕРАЦИИ: ПРОМЕЖУТОЧНЫЕ ИТОГИ. СООБЩЕНИЕ 1. 2020.</mixed-citation><mixed-citation xml:lang="en">Briko N.I., Korshunov V.A., Krasnova S.V., et al. Clinical and epidemiological characteristics of hospitalized patients with COVID-19 during different pandemic periods in</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Брико Н.И., Коршунов В.А., Краснова С.В., и др. Клинико-эпидемиологические особенности пациентов, госпитализированных с COVID-19 в различные периоды пандемии в Москве. Журнал микробиологии, эпидемиологии и иммунобиологии. 2022. Т. 99 №3. С. 287–299.</mixed-citation><mixed-citation xml:lang="en">Moscow. Journal of microbiology, epidemiology and immunobiology = Zhurnal mikrobiologii, èpidemiologii i immunobiologii. 2022;99(3):287–299. (In Russ.) DOI: https: doi.org/10.36233/0372-9311-272</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">N. Imai, I. Dorigatti, A. Cori, et al. Report 2: Estimating the potential total number of novel coronavirus cases in wuhan city, china. Technical report, Imperial College London (2020).</mixed-citation><mixed-citation xml:lang="en">Imai N. et al. Report 2: Estimating the potential total number of novel Coronavirus cases in Wuhan City, China. 2020. DOI: https: doi.org/10.25561/77150</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta, N. S., Mytton, O. T., Mullins, E. W., et al. SARS-CoV-2 (COVID-19): what do we know about children? A systematic review. Clinical Infectious Diseases. 2020. Vol. 71. №9. P. 2469–2479.</mixed-citation><mixed-citation xml:lang="en">Mehta, N. S., Mytton, O. T., Mullins, E. W., et al. SARS-CoV-2 (COVID-19): what do we know about children? A systematic review. Clinical Infectious Diseases. 2020; 71(9): 2469–2479.https: doi.org/10.1093/cid/ciaa556</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">S. Zhao, Q. Lin, J. Musa Ran et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-ncov) in china, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int. Journal Infect. Dis. 2020. Vol. 92. P. 214–217.</mixed-citation><mixed-citation xml:lang="en">S. Zhao, Q. Lin, J. Musa Ran et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-ncov) in china, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int. Journal Infect. Dis. 92 (2020) 214–217. https: doi.org/10.1016/j.ijid.2020.01.050</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">S. Zhao, S.S. Musa, Q. Lin, et al. Estimating the unreported number of novel coronavirus (2019-ncov) cases in china in the first half of january 2020: A data-driven modelling analysis of the early outbreak. Journal of clinical medicine. 2020. Vol. 9. №. 2. P. 388.</mixed-citation><mixed-citation xml:lang="en">S. Zhao, S.S. Musa, Q. Lin, et al., Estimating the unreported number of novel coronavirus (2019-ncov) cases in china in the first half of january 2020: A data-driven modelling analysis of the early outbreak. J. Clin. Med. 9 (2020) 388. https: doi.org/10.3390/jcm9020388</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Попова А. Ю. и др. Влияние ежегодной иммунизации населения против гриппа на заболеваемость этой инфекцией в Российской Федерации Эпидемиология и вакцинопрофилактика. 2016. Т. 15. №. 1 (86). С. 48</mixed-citation><mixed-citation xml:lang="en">A.Yu. Popova et al. The impact annual immunization against Flu on morbidity of Flu in the russian Federation. Peer-rewieved journal Epidemiology and Vaccinal Prevention. 2016; 1 (86): 48–55. (In Russ.) https: doi.org/10.31631/2073-3046-2016-15-1-48-55</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Похиленко В.Д., Перелыгин В.В. SARS-CoV-2 и как остановить: монография. Чебоксары: ИД «Среда», 2021. 88 с.</mixed-citation><mixed-citation xml:lang="en">Pokhilenko V.D., Perelygin V.V. SARS-CoV-2 and how to stop: monograph. Cheboksary: ID «Sreda»,2021: 88 с. (In Russ.) DOI 10.31483/a-10283</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Акимкин, В. Г., Давидова, Н. Г., Углева, и др. Эпидемические очаги COVID-19 в зарубежных закрытых учреждениях долговременного ухода. Эпидемиология и вакцинопрофилактика, 2022. Т. 21. №5. С. 138–146.</mixed-citation><mixed-citation xml:lang="en">Akimkin VG, Davydova NG., Ugleva SV et al. Epidemic outbreaks of COVID-19 in foreign closed long-term care facilities. Epidemiology and Vaccinal Prevention. 2022;21(5): 138–146 (In Russ.). https: doi:10.31631/2073-3046-2022-21-5-138-146</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Shallcross L, Burke D, Abbott O, et al. Factors associated with SARS-CoV-2 infection and outbreaks in long-term care facilities in England: a national cross-sectional survey. Lancet Healthy Longev. 2021. Vol. 2 №3. P. e129–e142.</mixed-citation><mixed-citation xml:lang="en">Shallcross L, Burke D, Abbott O, et al. Factors associated with SARS-CoV-2 infection and outbreaks in long-term care facilities in England: a national cross-sectional survey. Lancet Healthy Longev. 2021;2(3):e129–e142. doi: 10.1016/ S2666-7568(20)30065-9</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
