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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2024-23-5-33-41</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-2081</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эпидемиологические проявления гнойного бактериального менингита в Российской Федерации</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiological Manifestations of Purulent Bacterial Meningitis in the Russian Federation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2714-1191</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыденко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydenko</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давыденко Мария Александровна, д. м. н., ведущий научный сотрудник лаборатории эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов</p><p>111123, Москва, ул. Новогиреевская, д. 3а. +7 (916) 363-82-48</p></bio><bio xml:lang="en"><p>Maria A. Davydenko – Dr. Sci. (Med.), Leading Researcher, Laboratory of Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis</p><p>3a, Novogireevskaya str., Moscow, 111123 +7 (916) 363-82-48</p></bio><email xlink:type="simple">korolevamaria389@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5344-5829</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чурилова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Churilova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Надежда Сергеевна Чурилова – младший научный сотрудник лаборатории эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов</p><p>Москва</p></bio><bio xml:lang="en"><p>Nadezhda S. Churilova – Junior Researcher, Laboratory of Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis</p><p>Moscow</p></bio><email xlink:type="simple">n27101996@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0578-146X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королева</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Koroleva</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Станиславовна Королева – д. м. н., заведующая лабораторией эпидемиологии менингококковой инфекции и гнойных бактериальных менингитов</p><p>Москва</p></bio><bio xml:lang="en"><p>Irina S. Koroleva – Dr. Sci. (Med.), Professor, Head of the Laboratory of Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis</p><p>Moscow</p></bio><email xlink:type="simple">irina-korol@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Центральный НИИ Эпидемиологии» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Budget Institute of Science «Central Research Institute of Epidemiology» of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>11</month><year>2024</year></pub-date><volume>23</volume><issue>5</issue><fpage>33</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Давыденко М.А., Чурилова Н.С., Королева И.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Давыденко М.А., Чурилова Н.С., Королева И.С.</copyright-holder><copyright-holder xml:lang="en">Davydenko M.A., Churilova N.S., Koroleva I.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/2081">https://www.epidemvac.ru/jour/article/view/2081</self-uri><abstract><p>Цель. Определить эпидемиологические проявления гнойного бактериального менингита (ГБМ) в Российской Федерации в 2023 г. Материалы и методы. На базе Российского Референс-центра по мониторингу за бактериальными менингитами налажена углубленная персонифицированная система учета случаев ГБМ. С 2010 г. в систему мониторирования включены все территории РФ. В 2023 г. в Референс-центр поступила информация о 1837 случаях ГБМ. В работе использован описательно-оценочный эпидемиологический метод: ретроспективный анализ. Результаты и обсуждение. Заболеваемость ГБМ в РФ за четырнадцатилетний период наблюдения имеет тенденцию к снижению. Причинами 85% случаев ГБМ в РФ являются менингококк, пневмококк и гемофильная палочка, при этом инфекции, которые они вызывают, являются потенциально вакциноуправляемыми. Лидирующую позицию в этиологии ГБМ в РФ продолжает занимать менингококк, вызывая 50% от всех лабораторно-подтвержденных случаев. Несмотря на небольшое снижение заболеваемости менингококковой инфекцией в 2023 г., отмечен ее рост на 39% среди детей до 5 лет – в возрастной группе риска. В серогрупповой структуре менингококка впервые за изучаемый период выявлено преобладание менингококка серогруппы W. В 2023 г. отмечена самая высокая летальность от менингококковой инфекции – 21%. Заболеваемость пневмококковым менингитом в возрастной группе риска (дети до 5 лет) возросла в 2023 г. до 28%, а группами риска по летальности определены категории взрослых лиц. Заболеваемость менигитом, вызванным гемофильной палочкой, среди детей до 5 лет снизилась на 44%, и все случаи летального исхода, за исключением одного, отмечены именно в этой возрастной группе. Заключение. Анализ эпидемиологического проявления гнойного бактериального менингита в Российской Федерации в 2023 г. позволяет отслеживать этиологию ГБМ, возрастные группы и территории риска, что может послужить основой формирования тактики борьбы с заболеванием с приоритетом использования вакцинных препаратов.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. Although meningitis is largely preventable, it still causes hundreds of thousands of deaths worldwide each year. Significant progress has been made in reducing meningitis mortality over the past three decades. The incidence of meningococcal, pneumococcal, and Haemophilus influenzae type b meningitis has declined due to the introduction of vaccination into national immunization programs in countries around the world. Aim. To determine the epidemiological manifestations of purulent bacterial meningitis (GBM) in the Russian Federation (RF) in 2023. Materials and methods. An in-depth personalized system for recording purulent bacterial meningitis cases has been established at the Russian Reference Center for Bacterial Meningitis Monitoring. Since 2010, all territories of the Russian Federation have been included in the monitoring system. In 2023, the Reference Center received information on 1,837 cases of purulent bacterial meningitis. The paper uses a descriptive and evaluative epidemiological method: retrospective analysis. Results and discussion. The incidence of GBM in the Russian Federation over a fourteen-year observation period has a downward trend. Meningococcus, pneumococcus and Haemophilus influenzae are the causes of 85% of GBM cases in the Russian Federation, while the infections they cause are potentially vaccine-preventable. Meningococcus continues to occupy a leading position in the etiology of GBM in the Russian Federation, causing 50% of all laboratory-confirmed cases. Despite a slight decrease in the incidence of meningococcal infection in 2023, its increase in the age group at risk, children under 5 years of age, by 39% was noted. In the serogroup characteristics of meningococcus, for the first time in the studied period, the predominance of meningococcus serogroup W was revealed. In 2023, the highest mortality rate from meningococcal infection was noted – 21%. The incidence rate of pneumococcal meningitis in the age group at risk, children under 5 years old, increased to 28% in 2023, and categories of adults are defined as risk groups for mortality. The incidence of meningitis caused by Haemophilus influenzae among children under 5 years old decreased by 44%, and all cases of death, with the exception of one, were noted in this age group. Conclusion. The data obtained make it possible to track the etiology of GBM, age groups and risk areas, which can serve as a basis for developing tactics to combat the disease with priority use of vaccines.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бактериальный менингит</kwd><kwd>менингококковая инфекция</kwd><kwd>менингококк</kwd><kwd>пневмококк</kwd><kwd>гемофильная палочка</kwd><kwd>эпидемиология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bacterial meningitis</kwd><kwd>meningococcal infection</kwd><kwd>Neisseria meningitidis</kwd><kwd>Streptococcus pneumoniae</kwd><kwd>Haemophilus influenzae</kwd><kwd>epidemiology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">van de Beek D, Brouwer M, Hasbun R, et al. Community-acquired bacterial meningitis. Nat Rev Dis Primers. 2016;2:16074.</mixed-citation><mixed-citation xml:lang="en">van de Beek D, Brouwer M, Hasbun R, et al. Community-acquired bacterial meningitis. Nat Rev Dis Primers. 2016;2: 16074. doi:10.1038/nrdp.2016.74</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zunt JR, Kassebaum NJ, Blake N, et al. Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2018;17:1061–82.</mixed-citation><mixed-citation xml:lang="en">Zunt JR, Kassebaum NJ, Blake N, et al. Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2018;17:1061–82. doi: 10.1016/S1474-4422(18)30387-9</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Edmond K, Clark A, Korczak VS, et al. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis 2010;10:317–28.</mixed-citation><mixed-citation xml:lang="en">Edmond K, Clark A, Korczak VS, et al. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:317–28. doi: 10.1016/S1473-3099(10)70048-7</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hudson JA, Broad J, Martin NG, et al. Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review. Rev Med Virol 2020;30:e2083.</mixed-citation><mixed-citation xml:lang="en">Hudson JA, Broad J, Martin NG, et al. Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review. Rev Med Virol 2020; 30:e2083. doi: 10.1002/rmv.2083</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mount HR, Boyle SD. Aseptic and bacterial meningitis: evaluation, treatment, and prevention. Am Fam Physician. 2017;96:314–22.</mixed-citation><mixed-citation xml:lang="en">Mount HR, Boyle SD. Aseptic and bacterial meningitis: evaluation, treatment, and prevention. Am Fam Physician. 2017;96:314–22.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wall EC, Chan JM, Gil E, Heyderman RS. Acute bacterial meningitis // Curr Opin Neurol. 2021;34:386–95.</mixed-citation><mixed-citation xml:lang="en">Wall EC, Chan JM, Gil E, et al. Acute bacterial meningitis. Curr Opin Neurol 2021;34:386–95. doi: 10.1097/WCO.0000000000000934</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wunrow, HY, Bender, RG, Vongpradith, A, et al. Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology. 2023;22(8): 685–711.</mixed-citation><mixed-citation xml:lang="en">Wunrow, HY, Bender, RG, Vongpradith, A, et al. Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology. 2023;22(8), 685–711. doi: 10.1016/S1474-4422(23)00195-3</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Королева, М. А., Грицай, М. И., Чурилова, Н. С., Королева, И. С.. Эпидемиологические особенности гнойного бактериального менингита в Российской Федерации на современном этапе. Эпидемиология и Вакцинопрофилактика. 2023;22(4);67–74.</mixed-citation><mixed-citation xml:lang="en">Koroleva MA, Gritsai MI, Churilova NS, Koroleva IS. Epidemiological features of purulent bacterial meningitis in the Russian Federation at the present stage. Epidemiology and Vaccine Prevention. 2023;22(4),67–74 (In Russ.). doi: 10.31631/2073-3046-2023-22-4-67-74</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
