References

epidemiology

Эпидемиология и Вакцинопрофилактика

Epidemiology and Vaccinal Prevention

2073-30462619-0494

«Numicom» LLC

10.31631/2073-3046-2024-23-6-147-159

epidemiology-2130

Research Article

ОБЗОР

REVIEW

Генетическое разнообразие бартонелл, вызывающих патологические состояния у человека

Genetic Diversity of Bartonella Causing Pathological Conditions in Humans

https://orcid.org/0000-0003-2532-0054

Чеканова

Т. А.

Chekanova

T. A.

Татьяна Александровна Чеканова – к. б. н., заведующая лабораторией эпидемиологии природно-очаговых инфекций

Москва

+7 (903) 195-26-42

Tatiana A. Chekanova – Cand. Sci. (Biol.), Head of Laboratory for Natural Focal Infection Epidemiology

Moscow

+7 (903) 195-26-42

tchekanova74@mail.ru

https://orcid.org/0000-0002-1146-1430

Манзенюк

И. Н.

Manzeniuk

I. N.

Игорь Николаевич Манзенюк – к. м. н., помощник директора по научной работе

Москва

+7 (926) 296-06-04

Igor N.Manzeniuk – Cand. Sci. (Med.), Aide to Director of Institute (Scientific work)

Moscow

+7 (926) 296-06-04

manzeniuk@cmd.su

ФБУН «ЦНИИ Эпидемиологии» РоспотребнадзораРоссияCentral Research Institute of Epidemiology RospotrebnadzoraRussian Federation

2024

15012025

236147159

2025

Чеканова Т.А., Манзенюк И.Н.

Chekanova T.A., Manzeniuk I.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epidemvac.ru/jour/article/view/2130

Актуальность. Бартонеллезы – общее название группы инфекционных заболеваний с высоким зоонозным потенциалом. Род Bartonella отличает большое видовое разнообразие. Как минимум 20 таксонов известны на сегодня как патогенные для человека, однако эпидемиология бартонеллезов и их вклад в инфекционную патологию человека по-прежнему остаются малоизученными.Цель. На основе анализа научных публикаций дать оценку геновидового разнообразия бартонелл, их географического распространения, с особым вниманием к патогенным для человека таксонам, а также состояния вопроса изучения эпидемиологии бартонеллезов на современном уровне.Выводы. Бартонеллы потенциально имеют важное эпидемиологическое значение в силу значительного видового разнообразия и высокой встречаемости в различных экологических нишах. В настоящее время в РФ отсутствует официальная регистрация случаев бартонеллезной инфекции, а ресурсы для лабораторного подтверждения ограничены. В связи с этим бартонеллезы остаются недооцененной инфекционистами группой заболеваний, несмотря на рост числа открытых в последнее время видов бартонелл.

Relevance. Bartonelloses is a group of infectious diseases caused by bacteria from the Bartonella genus with a high zoonotic potential. This genus has a large genetic diversity, with many candidate species, and at least 20 known as a pathogenic for humans. However, the epidemiology of these diseases and their role in human infectious pathology are not well understood.Aim of this review is to collect and organize data in order to better understand the genetic diversity and distribution of Bartonella species, with a particular focus on those that are pathogenic to humans. We will also discuss the current state of research on the epidemiology of bartonelloses.Conclusions. Bartonella genus have the potential to be of significant epidemiological importance due to their wide species diversity and frequent occurrence in various ecological niches. However, there is currently no official registration of bartonelloses in the Russian Federation and laboratory confirmation resources are limited. As a result, bartonelloses remains an underestimated disease group among infectious disease specialists despite recent discoveries of Bartonella species.

виды бартонеллбартонеллезычеловекгенетическое разнообразие бартонеллэпидемиология бартонеллезной инфекции

Bartonella speciesbartonelloseshumansgenetic diversity of Bartonellaepidemiology of bartonelloses

References1

LPSN bacterio.net. Доступно наAvailable at: https://lpsn.dsmz.de/genus/bartonella. Cсылка действительна на 09.08.2024 г.The link is valid in 09.08.2024

LPSN bacterio.net. Доступно на\Available at: https://lpsn.dsmz.de/genus/bartonella. Cсылка действительна на 09.08.2024 г.\The link is valid in 09.08.2024

Kumar S, Stecher G, Suleski M, et al. TimeTree: a resource for timelines, timetrees, and divergence times./Molecular biology and evolution. 2017 Vol.34, N7. P. 1812–1819.

Marin J, Battistuzzi FU, Brown AC, et al. The Timetree of Prokaryotes: New Insights into Their Evolution and Speciation. Molecular biology and evolution. 2017 Vol. 34, N2. P. 437–446.

Segers FH, Kešnerová L, Kosoy M, et al. Genomic changes associated with the evolutionary transition of an insect gut symbiont into a blood-borne pathogen. The ISME journal. 2017 Vol. 11, N5. P. 1232–1244.

McKee C.D., Bai Y, Webb CT, et al. Bats are key hosts in the radiation of mammal-associated Bartonella bacteria. Infection, Genetics and Evolution. 2021 Vol. 89. P. 104719.

Brenner DJ, O’Connor SP, Winkler HH, et al. Proposals to unify the genera Bartonella and Rochalimaea, with descriptions of Bartonella quintana comb. nov., Bartonella vinsonii comb. nov., Bartonella henselae comb. nov., and Bartonella elizabethae comb. nov., and to remove the family Bartonellaceae from the order Rickettsiales. International journal of systematic bacteriology. 1993 Vol.43, N4. P. 777–886.

Birtles RJ, Harrison TG, Saunders NA, et al. Proposals to unify the genera Grahamella and Bartonella, with descriptions of Bartonella talpae comb. nov., Bartonella peromysci comb. nov., and three new species, Bartonella grahamii sp. nov., Bartonella taylorii sp. nov., and Bartonella doshiae sp. nov. International journal of systematic bacteriology. 1995 Vol.45. P.1–8.

Houpikian P, Raoult D. Molecular phylogeny of the genus Bartonella: what is the current knowledge? FEMS microbiology letters. 2001 Vol. 200, N1. P. 1–7.

Wagner A, Dehio C. Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species. Cell Microbiology. 2019 Vol.21 P.e13004.

Jackson LA, Spach DH. Emergence of Bartonella quintana infection among homeless persons. Emerging infectious diseases. 1996 Vol.2. P.141–144.

Krügel M, Król N, Kempf V, et al. Emerging rodent-associated Bartonella: a threat for human health? Parasites & Vectors. 2022 Vol.15,113.

Jiyipong T, Jittapalapong S, Morand S, et al. Bartonella species in small mammals and their potential vectors in Asia. Asian Pacific Journal of Tropical Biomedicine. 2014 Vol. 4, N10. P.757–767.

Breitschwerdt EB, Kordick DL. Bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection. Clinical microbiology reviews. 2000 Vol.13, N3.P.428–438.

Chomel BB, Kasten RW. Bartonellosis, an increasingly recognized zoonosis. Journal of applied microbiology. 2010 Vol.109, N3. P.743–750.

Portillo A, Santibáñez S, García-Álvarez L, et al. Rickettsioses in Europe. Microbes and infection. 2015 Vol. 17, N11-12. P. 834–838.

Mascarelli PE, Maggi RG, Hopkins S, et al. Bartonella henselae infection in a family experiencing neurological and neurocognitive abnormalities after woodlouse hunter spider bites. Parasites & vectors. 2013 Vol.6, 98.

Guru PK, Agarwal A, Fritz A. A miraculous recovery: Bartonella henselae infection following a red ant bite. BMJ case reports. 2018, bcr2017222326.

Regier Y, Rourke F, Kempf VA. Bartonella spp. – a chance to establish One Health concepts in veterinary and human medicine. Parasites & vectors. 2016 Vol.9, N1, 261.

Kosoy M, Goodrich I. Comparative Ecology of Bartonella and Brucella Infections in Wild Carnivores. Frontiers in veterinary science. 2019 Vol.5, 322.

Cheslock M, Embers M. Human Bartonellosis: An Underappreciated Public Health Problem? Tropical medicine and infectious disease. 2019 Vol.4,N2, 69.

Dietrich F, Schmidgen T, Maggi RG, et al. Prevalence of Bartonella henselae and Borrelia burgdorferi sensu lato DNA in Ixodes ricinus ticks in Europe. Applied and environmental microbiology. 2010 Vol.76, N5. P. 1395–1398.

Del Valle-Mendoza J, Rojas-Jaimes J, Vasquez-Achaya F, et al. Molecular identification of Bartonella bacilliformis in ticks collected from two species of wild mammals in Madre de Dios: Peru. BMC research notes. 2018.Vol.11, N1.P. 405.

Angelakis E, Pulcini C, Waton J, et al. Scalp eschar and neck lymphadenopathy caused by Bartonella henselae after tick bite. Clinical infectious diseases.2010 Vol.50,N4. P. 549–551.

Telford SR, Wormser GP. Bartonella spp. transmission by ticks not established./ Emerging Infection Diseases. 2010 Vol.16. P.379–384.

Minnick MF, Anderson BE Chapter 105 – Bartonella. In: Tang YW, Sussman M, Liu D, et al. Molecular Medical Microbiology. 2nd ed. Academic Press. Boston, FL, USA. 2015 P. 1911–1939.

Jin X, Gou Y, Xin Y, et al. Advancements in understanding the molecular and immune mechanisms of Bartonella pathogenicity. Frontiers in microbiology. 2023 Vol.14, 1196700.

Fromm K, Dehio Ch. The Impact of Bartonella VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells. Frontiers in microbiology. 2021 Vol.12, 762582.

Chomel BB, Boulouis HJ, Breitschwerdt EB, et al. Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors. Veterinary research. 2009 Vol. 40,29.

Angelakis E, Raoult D. Pathogenicity and treatment of bartonella infections. International journal of antimicrobial agents. 2014 Vol.44. P.16–25.

Сhomel BB, Boulouis HJ, Breitschwerdt EB. Cat scratch disease and other zoonotic Bartonella infections. Journal of the American Veterinary Medical Association. 2004 Vol.224, N8.P.1270–1279.

Oksi J, Rantala S, Kilpinen S, et al. Cat scratch disease caused by Bartonella grahamii in an immunocompromised patient. Journal of clinical microbiology. 2013 Vol. 51, N8. P. 2781– 2784.

Lins KA, Drummond MR, Velho PE. Cutaneous manifestations of bartonellosis./Anais brasileiros de dermatologia. 2019 Vol. 94, N5. P. 594–602.

Alexander B. A review of bartonellosis in Ecuador and Colombia.The American journal of tropical medicine and hygiene.1995 Vol.52, N4. P.354–359

Stuckeya MJ, Chomela BB, Henri-Jean EC, et al. Bartonella, bats and bugs: a review. Comparative Immunology, Microbiology and Infectious Diseases. 2017 Vol. 55. P. 20–29.

Kosoy M, Saito E, Green D, et al. Experimental evidence of host specificity of Bartonella infection in rodents. Comparative Immunology, Microbiology and Infectious Diseases. 2000 Vol.23. P. 221–238.

Brock TD. Robert Koch, a life in medicine and bacteriology.ASM Press, Washington, D.C. 1999 P. 1–364.

Drancourt M, Tran-Hung L, Courtin J, et al. Bartonella quintana in a 4000-year-old human tooth. The Journal of infectious diseases. 2005 Vol.191,N4. P.607–611.

Barbieri R, Mai B-H-A, Chenal T, et al. A 2,000-year-old specimen with intraerythrocytic Bartonella quintana. Scientific reports. 2020 Vol.10, N1, 10069.

Alexander B. A review of bartonellosis in Ecuador and Colombia. The American journal of tropical medicine and hygiene.1995 Vol.52. P.354–359

Breitschwerdt EB, Maggi RG, Chomel BB, et al. Bartonellosis: an emerging infectious disease of zoonotic importance to animals and human beings. Journal of veterinary emergency and critical care.2010 Vol.20, N1. P.8–30.

Kaiser PO, Riess T, O’Rourke F, et al. Bartonella spp.: throwing light on uncommon human infections. International journal of medical microbiology. 2011 Vol.301,N1. P.7–15.

Lamas C, Curi A, Bóia MN, et al. Human bartonellosis: seroepidemiological and clinical features with an emphasis on data from Brazil – a review. Memorias do Instituto Oswaldo Cruz. 2008. Vol.103, N1. P. 221–235.

Nelson CA, Saha S, Mead PS. Cat-Scratch Disease in the United States, 2005–2013. Emerging infectious diseases. 2016 Vol.22, N10. P.1741–1746.

Oliveira AM, Maggi RG, Woods CW, et al. Suspected needle stick transmission of Bartonella vinsonii subspecies berkhoffii to a veterinarian. J Vet Intern Med. 2010;24:1229–32.

Lantos PM, Maggi RG, Ferguson B, et al. Detection of Bartonella species in the blood of veterinarians and veterinary technicians: a newly recognized occupational hazard? Vector Borne Zoonotic Dis. 2014 Vol.14. P.563–70.

Jurke A, Bannert N, Brehm K, et al. Serological survey of Bartonella spp., Borrelia burgdorferi, Brucella spp., Coxiella burnetii, Francisella tularensis, spp., Echinococcus, Hanta-, TBE- and XMR-virus infection in employees of two forestry enterprises in North Rhine–Westphalia, Germany, 2011–2013. International journal of medical microbiology. 2015 Vol.305, N7.P.652–662.

Oteo JA, Maggi R, Portillo A, et al. Prevalence of Bartonella spp. by culture, PCR and serology, in veterinary personnel from Spain. Parasit & Vectors. 2017 Vol.10. P.1–9.

Breitschwerdt EB. Did Bartonella henselae contribute to the deaths of two veterinarians? Parasit & Vectors. 2015 Vol.8. P.317.

Jackson LA, Spaeh DH, Kippen DA, et al. Seroprevalence to Bartonella quintana among patients at a community clinic in downtown Seattle. The Journal of infectious diseases. 1996 Vol.173.P.1023–1026.

Foucault C, Brouqui P, Raoult D. Bartonella quintana characteristics and clinical management. Emerging infectious diseases. 2006 Vol.12. P. 217–223.

Smith HM, Reporter R, Rood MP, et al. Prevalence study of antibody to ratborne pathogens and other agents among patients using a free clinic in downtown Los Angeles. The Journal of infectious diseases. 2002 Vol.186.P.1673–1676.

Orellana-Rios J, Verdaguer-Diaz JI, Opazo G, et al. Not cat-scratch disease: Bartonella henselae neuroretinitis associated with non-feline pet mammals. IDCases. 2020 Vol. 22. P. e00978.

R. Gutiérrez, T. Shalit, B. Markus, et al. Bartonella kosoyi sp. nov. and Bartonella krasnovii sp. nov., two novel species closely related to the zoonotic Bartonella elizabethae, isolated from black rats and wild desert rodent-fleas .International journal of systematic and evolutionary microbiology. 2020 Vol.70, N3.P.1656–1665. P. 10.1099/ ijsem.0.003952.

Holden K, Boothby JT, Kasten RW, et al. Co-detection of Bartonella henselae, Borrelia burgdorferi, and Anaplasma phagocytophilum in Ixodes pacificus ticks from California, USA. Vector Borne Zoonotic Dis. 2006 Vol. 6. P. 99–102.

Belongia EA. Epidemiology and impact of coinfections acquired from Ixodes ticks. Vector Borne Zoonotic Diseases. 2002 Vol. 2. P. 265–273.

Halos L., Jamal T., Maillard R., et al. Evidence of Bartonella sp. in questing adult and nymphal Ixodes ricinus ticks from France and co-infection with Borrelia burgdorferi sensu lato and Babesia sp. Veterinary research. 2005 Vol. 36. P. 79–87.

Rar VA, Fomenko NV, Dobrotvorsky AK, et al. Tick-borne Pathogen Detection, Western Siberia, Russia. Emerging infectious diseases. 2005 Vol. 11. N 11. P. 1708–1715.

Круглов А. Н., Осадчая В. А., Фролова Г. П. и др. Первые случаи заболеваний, вызванных бактериями рода Bartonella, в России. Инфекционные болезни. 2006 T.4, №3. С.64–68.

Kruglov A.N., Osadchaya V.A., Frolova G.P. i dr. Pervyye sluchai zabolevaniy, vyzvannykh bakteriyami roda Bartonella, v Rossii. Infektsionnyye bolezni 2006; 4(3):64–8. (In Russ.).

Мазанкова Л. Н., Харламова Ф. С., Османов И. М. и др. Бартонеллез (болезнь кошачьих царапин) у детей. Российский вестник перинатологии и педиатрии. 2018 Т. 63, N3. P. 112–117.

Mazankova L.N., Kharlamova F.S., Оsmanov I.M., et al. Bartonrllosis (cat-scrath disease) in children. Russian Bulletin of Perinatology and Pediatrics. 2018;63(3):112–7. (In Russ.). doi:10.21508/1027-4065-2018-63-3

Лунякова М. А., Демихов В. Г., Инякова Н. В., Панина Е. А. Атипичное течение бартонеллеза с гепатолиенальным поражением. Pediatric Hematology, Oncology and Immunopathology. 2021 T. 20, №1. С.136–144.

Lunyakova M.A., Demikhov V.G., Inyakova N.V., et al. Atypical presentation of bartonellosis with hepatolienal lesions. Pediatric Hematology/Oncology and Immunopathology. 2021;20(1):136–144. (In Russ.) doi:10.24287/1726-1708-2021-20-1-136-144

Морозова О. В., Петрожицкая Л. В., Черноусова Н. Я. и др. Детекция ДНК бартонелл в иксодовых клещах, комарах и крови больных в Новосибирской области. Бюллетень сибирской медицины. 2006 №1. С.106–110.

Morozova O.V., Petrozhitskaya L.V., Chernousova N.Ya., et al. Detection of bartonella DNA in ixodid ticks, mosquitoes and in patients blood in Novosibirsk region. Bulletin of Siberian Medicine. 2006;5:106–110. (In Russ.) doi:10.20538/1682-0363-2006--106-110

Rydkina EB, Roux V, Gagua EM, et al. Bartonella quintana in body lice collected from homeless persons in Russia. Emerging infectious diseases. 1999 Vol.5, N1. P.176–178.

Mediannikov O, Ivanov L, Zdanovskaya N, et al. Molecular Screening of Bartonella Species in Rodents from the Russian Far. Annals of the New York Academy of Sciences. 2005 Vol.1063. P.308–311.

Morozova OV, Cabello FC, Dobrotvorsky AK. Semi-nested PCR detection of Bartonella henselae in Ixodes persulcatus ticks from Western Siberia, Russia.Vector Borne Zoonotic Diseases. 2004 Vol.4. P.306–309.

Чеканова Т. А., Манзенюк И. Н. Клещевые возвратные лихорадки и геновидовое разнообразие боррелий: текущее состояние вопроса. Эпидемиология и Вакцинопрофилактика. 2021 Т. 20, №6. С.108–116.

Chekanova T.A., Manzeniuk I.N. Tick-Born Relapsing Fever and Genespecies Diversity of Borrelia: Current Status. Epidemiology and Vaccinal Prevention. 2021;20(6):108–16. (In Russ.). doi: 10.31631/2073-3046-2021-20-6-108-116

The authors declare that there are no conflicts of interest present.