epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2024-23-6-160-168epidemiology-2131Research ArticleОБЗОРREVIEWХолера Бенгал: эпидемиологический мониторинг и геномный анализ штаммов Vibrio cholerae O139Cholera Bengal: Epidemiological Monitoring and Genomic Analysis of Strains V. cholerae O139https://orcid.org/0000-0001-5020-1466МосквитинаЭ. А.MoskvitinaE. A.

Эльза Афанасьевна Москвитина – д. м. н, профессор, главный научный сотрудник

Ростов-на-Дону

+7 (863) 240-27-03

Elsa A. Moskvitina – Dr. Sci. (Med.), Professor, Chief Researcher

Rostov-on-Don

+7 (863) 240-27-03

Elza_epid@mail.ruФКУЗ Ростовский-на-Дону противочумный институт РоспотребнадзораРоссияFederal State Health Care Institution "Rostov-on-Don Anti- plague Institute" of the RospotrebnadzorRussian Federation202415012025236160168Copyright © Москвитина Э.А., 20252025Москвитина Э.А.Moskvitina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/2131

Актуальность. Вспышки, спорадические случаи и межконтинентальные завозы холеры Бенгал, вызываемые выявленной впервые в 1992 г. Vibrio cholerae O139 серогруппы, отмечаются ежегодно преимущественно в Азии. V. cholerae O139 и V. cholerae О1 генетически родственны, и вызываемая ими болезнь протекает одинаково.Цель. Охарактеризовать распространение холеры Бенгал в России и мире во взаимосвязи со свойствами V. cholerae O139.Результаты. Приведены данные об эпидемических проявлениях холеры Бенгал во взаимосвязи с фенотипическими и молекулярно-биологическими свойствами V. cholerae О139. Описана эволюция генома и последовательные события интродукции V. cholerae O139.Заключение. Регистрация единичных случаев холеры Бенгал в последнее десятилетие, выявление в Китае больного холерой, вызванной V. cholerae O139 с геном ctxAB+, лекарственная устойчивость к ряду антибиотиков делает холеру Бенгал в настоящее время существенной проблемой.

Relevance. Major outbreaks, sporadic cases and intercontinental shipments of Bengal cholera caused by Vibrio cholerae O139 occurred from 1992 to 2018 in 26 countries, including 16 Asian countries.Аim. To characterize the spread of Bengal cholera in the world, including in Russia, in relation to the properties of V. cholerae O139.Results. Data on epidemic manifestations of Bengal cholera in the world, including in Russia, in relation to the phenotypic and molecular biological properties of V. cholerae O139 strains are presented. The evolution of their genome and the successive events of the introduction of V. cholerae O139 are described. Conclusion. The isolation of V. cholerae O139 from a patient with ctxAB+ gene, drug resistance to a number of antibiotics in China in 2023 indicates that the problem of Bengal cholera has been continued still in the modern period.

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The authors declare that there are no conflicts of interest present.