epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2016-15-6-80-87epidemiology-219Research ArticleВАКЦИНОПРОФИЛАКТИКАVACCINAL PREVENTIONМеханизмы клеточного иммунного ответа при бруцеллезеThe Mechanisms of CellularImmune Response in BrucellosisДубровинаВ. И.DubrovinaV. I.dubrovina-valya@mail.ruКоноваловаЖ. А.KonovalovaZh. A.noemail@neicon.ruЯстремскаяК. Ю.YastremskayaK. U.noemail@neicon.ruБаранниковаН. Л.BarannikovaN. L.noemail@neicon.ruТокареваЛ. Е.TokarevaL. E.noemail@neicon.ruБалахоновС. В.BalakhonovS. V.noemail@neicon.ruФКУЗ «Иркутский научно-исследовательский противочумный институт Роспотребнадзора»РоссияIrkutsk Antlplague Research Institute of Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingRussian Federation2016201220161568087Copyright © Дубровина В.И., Коновалова Ж.А., Ястремская К.Ю., Баранникова Н.Л., Токарева Л.Е., Балахонов С.В., 20162016Дубровина В.И., Коновалова Ж.А., Ястремская К.Ю., Баранникова Н.Л., Токарева Л.Е., Балахонов С.В.Dubrovina V.I., Konovalova Z.A., Yastremskaya K.U., Barannikova N.L., Tokareva L.E., Balakhonov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/219

В обзоре обсуждается современное состояние вопроса взаимодействия бруцелл с макроорганизмом. Приведены сведения о механизмах персистенции бруцелл в организме хозяина за счет их способности длительно сохраняться в клетках иммунофагоцитарной системы. Представлены данные о различиях бруцелл в гладкой и шероховатой формах по инвазивной способности. Показана роль макрофагов в бруцеллезной инфекции. Обозначены перспективные направления исследований в области иммунобиологии бруцеллеза.

The current state of the problem of Brucella interactions with the host in the review is discussesed. Provides information about the mechanisms of persistence of Brucella in the host organism due to their ability long remain in the cells immunoregulatory system. Data on the differences of Brucella in smooth and rough forms on invasive ability are presented. The key role of the macrophage in Brucella infection is shown. Promising areas of research in the field of immunobiology of brucellosis are indicated.

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The authors declare that there are no conflicts of interest present.