epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2026-25-1-99-110epidemiology-2380Research ArticleОБЗОРREVIEWМолекулярно-биологическая характеристика стрептококков группы MitisMolecular biological characteristics of Mitis group streptococcihttps://orcid.org/0000-0002-1922-4640ГруберИ. М.GruberI. M.

Ирина Мироновна Грубер – д. м. н., профессор, главный научный сотрудник лаборатории экспериментальной микробиологии

+7 (495) 916-20-47

Москва

Irina M. Gruber – Dr. Sci. (Med.), Professor, Chief Researcher of the Laboratory of Experimental Microbiology

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igruber_instmech@mail.ruhttps://orcid.org/0000-0003-0875-4141АфанасьеваО. М.AfanasyevaO. M.

Ольга Максимовна Афанасьева – к. м. н., научный сотрудник лаборатории экспериментальной микробиологии

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Москва

Olga M. Afanasyeva – Cand. Sci. (Med.), researcher of the Laboratory of experimental microbiology

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kukina1994@mail.ruhttps://orcid.org/0000-0002-1926-8803ВоробьевД. С.VorobyevD. S.

Денис Сергеевич Воробьев – к. м. н., заведующий лабораторией экспериментальной микробиологии; доцент кафедры микробиологии, вирусологии и иммунологии

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Москва

Denis S. Vorobyev – Cand. Sci. (Med.), Head of the Laboratory of Experimental Microbiology; Associate Professor of the Department of Microbiology, Virology and Immunology

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vorobievdenis@yandex.ruhttps://orcid.org/0000-0002-3958-6219ЖигуноваО. В.ZhigunovaO. V.

Ольга Валерьевна Жигунова – младший научный сотрудник лаборатории экспериментальной микробиологии

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Москва

OlgaV. Zhigunova – junior researcher at the Laboratory of Experimental Microbiology

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kileva@mail.ruФГБНУ «Научно-исследовательский институт вакцин и сывороток имени И.И. Мечникова»РоссияFederal State Budget Institution of Science « Mechnikov Research Institute of Vaccines and Sera»Russian FederationФГБНУ «Научно-исследовательский институт вакцин и сывороток имени И.И. Мечникова»; ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияFederal State Budget Institution of Science « Mechnikov Research Institute of Vaccines and Sera»; Sechenov UniversityRussian Federation20261303202625199110Copyright © Грубер И.М., Афанасьева О.М., Воробьев Д.С., Жигунова О.В., 20262026Грубер И.М., Афанасьева О.М., Воробьев Д.С., Жигунова О.В.Gruber I.M., Afanasyeva O.M., Vorobyev D.S., Zhigunova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/2380

Актуальность. Стрептококки группы Mitis (Mitis Group Streptococci, SMG), относящиеся к одной из 5 групп зеленящих стрептококков, являются компонентом нормальной назофарингеальной флоры человека и включают 17 известных видов. Среди SMG, Streptococcus pneumoniae выступает наиболее частым возбудителем ряда инвазивных и неинвазивных заболеваний человека, приводящих к высокому уровню смертности во всем мире. Интересно отметить, что в ряде работ показаны не только различия, но и совпадения в генах, кодирующих факторы патогенности S. pneumoniae и других представителей SMG, в частности, Streptococcus oralis. Цель. Проанализировать и обобщить данные результатов молекулярно-генетических исследований SMG и выявить особенности генетического разнообразия штаммов возбудителей. Заключение. Проведенный сравнительный анализ геномов близкородственных видов SMG выявил ключевые общие гены, кодирующие белки – основные факторы патогенности, что позволяет оптимизировать выбор кандидатных штаммов для разработки эффективных пневмококковых вакцин.

Relevance. Mitis Group Streptococci (SMG), which belong to one of the 5 groups of greening streptococci, are a component of the normal human nasopharyngeal flora and include 17 known species. Among SMG, Streptococcus pneumoniae is the most common cause of a number of invasive and non-invasive human diseases that lead to high mortality rates worldwide. It is interesting to note that a number of studies have shown not only differences, but also similarities in the genes encoding the pathogenicity factors of S. pneumoniae and other members of the SMG, particularly Streptococcus oralis. Aims. To analyze and summarize the results of molecular genetic studies of the SMG and identify the features of the genetic diversity of the pathogen strains. Conclusion. The comparative analysis of the genomes of closely related SMG species revealed key common genes encoding the main pathogenicity factors, which allows for the optimization of the selection of candidate strains for development.

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The authors declare that there are no conflicts of interest present.