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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/207330462026254414</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-2487</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОБЛЕМНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PROBLEM-SOLVING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Вспышка инфекции, вызванной хантавирусом Андес на судне MV Hondius  (апрель – май 2026 г.): уроки по обеспечению региональной и международной биобезопасности</article-title><trans-title-group xml:lang="en"><trans-title>Outbreak of Andes Virus Infection on Board MV Hondius, April – May 2026: Lessons for Biosafety Preparedness</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4228-9044</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акимкин</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Akimkin</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акимкин Василий Геннадьевич – академик РАН, д.м.н., профессор, директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Vasily G. Akimkin – Academician of the Russian Academy of Sciences, Dr. Sci. (Med.), Professor, Director</p><p>Moscow</p></bio><email xlink:type="simple">crie@pcr.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8176-6582</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Львов</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Lvov</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Львов Дмитрий Константинович – академик РАН, д.м.н., профессор, главный научный сотрудник </p><p>Москва</p></bio><bio xml:lang="en"><p>Dmitry K. Lvov – Academician of the Russian Academy of Sciences, Dr. Sci. (Med.), Professor, Chief Researcher</p><p>Moscow</p></bio><email xlink:type="simple">dk_lvov@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2570-711X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пшеничная</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pshenichnaya</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пшеничная Наталья Юрьевна – д. м. н., профессор, заместитель директора по клинико-аналитической работе</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia Yu. Pshenichnaya – Dr. Sci. (Med.), Professor, Deputy Director for Clinical and Analytical Work</p><p>Moscow</p></bio><email xlink:type="simple">pshenichnaya@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2269-2533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Музыка</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Muzyka</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Музыка Анна Драгиевна – к. м. н., старший научный сотрудник Клинического отдела инфекционной патологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Anna D. Muzyka – Cand. Sci. (Med.), Senior Researcher, Clinical Department of Infectious Pathology</p><p>Moscow</p></bio><email xlink:type="simple">Amyzika@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5524-0296</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хафизов</surname><given-names>К. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Khafizov</surname><given-names>K. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хафизов Камиль Фаридович – к. б. н., заведующий лабораторией геномных исследований</p><p>Москва</p></bio><bio xml:lang="en"><p>Kamil F. Khafizov – Cand. Sci. (Biol.), Head, Laboratory for Genomic Research</p><p>Moscow</p></bio><email xlink:type="simple">khafizov@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2353-5222</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Роев</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Roev</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Роев Герман Викторович – биоинформатик лаборатории геномных исследований</p><p>Москва</p></bio><bio xml:lang="en"><p>German V. Roev – bioinformatician, Laboratory for Genomic Research</p><p>Moscow</p></bio><email xlink:type="simple">roevherman@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2249-7196</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аглетдинов</surname><given-names>З. М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Agletdinov</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аглетдинов Матвей Рашидович – биоинформатик лаборатории геномных исследований</p><p>Москва</p></bio><bio xml:lang="en"><p>Matvey R. Agletdinov – bioinformatician, Laboratory for Genomic Research</p><p>Moscow</p></bio><email xlink:type="simple">agletdinov@cmd.su</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3612-1889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плоскирева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ploskireva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плоскирева Антонина Александровна – д. м. н., профессор РАН, заместитель директора по клинической работе</p><p>Москва</p></bio><bio xml:lang="en"><p>Antonina A. Ploskireva – Dr. Sci. (Med.), Professor of the Russian Academy of Sciences, Deputy Director for Clinical Work</p><p>Moscow</p></bio><email xlink:type="simple">a.ploskireva@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8407-2623</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозкин</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozkin</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозкин Евгений Сергеевич – к. х. н., руководитель научной группы разработки новых методов диагностики природно-очаговых заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Evgeny S. Morozkin – Cand. Sci. (Chem.), Head, Research Group for the Development of New Diagnostic Methods for Natural Focal Diseases</p><p>Moscow</p></bio><email xlink:type="simple">morozkin@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7970-7495</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черкашина</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherkashina</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черкашина Анна Сергеевна – к. х. н., заведующий лабораторией биотехнологии и молекулярной биологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Anna S. Cherkashina – Cand. Sci. (Chem.), Head, Laboratory of Biotechnology and Molecular Biology</p><p>Moscow</p></bio><email xlink:type="simple">cherkashina@pcr.ms</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3627-6047</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черкашин</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherkashin</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черкашин Евгений Александрович – к. х. н., руководитель центра разработки, развития продукции и инноваций</p><p>Москва</p></bio><bio xml:lang="en"><p>Evgeny A. Cherkashin – Cand. Sci. (Chem.), Head, Center for Development, Product Development and Innovation</p><p>Moscow</p></bio><email xlink:type="simple">cherkashin@pcr.ms</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0121-521X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гасанов</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gasanov</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гасанов Гасан Алиевич – к. м. н., старший научный сотрудник лаборатории молекулярной эпидемиологии и иммунологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Gasan A. Gasanov – Cand. Sci. (Med.), Senior Researcher, Scientist, Laboratory of Molecular Epidemiology and Immunology</p><p>Moscow</p></bio><email xlink:type="simple">gasanov@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5456-7649</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Есьман</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Esman</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Есьман Анна Сергеевна – к. м. н., заведующий лабораторией молекулярной эпидемиологии и иммунологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Anna S. Esman – Cand. Sci. (Med.), Head, Laboratory of Molecular Epidemiology and Immunology</p><p>Moscow</p></bio><email xlink:type="simple">esman@cmd.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6913-5841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Альховский</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Alkhovsky</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Альховский Сергей Владимирович – член-корреспондент РАН, д.б.н., советник директора по научной работе в области природно-очаговых и новых инфекций</p><p>+7 (495) 672-10-69</p><p>111123, г. Москва, ул. Новогиреевская, д. 3а</p></bio><bio xml:lang="en"><p>Sergey V. Alkhovsky – Corresponding Member of the Russian Academy of Sciences, Dr. Sci. (Biol.), Advisor to the Director for Scientific Work in the Field  of Natural Focal and Emerging Infections</p><p>+7 (495) 672-10-69</p><p>3a Novogireevskaya str., Moscow, 111123</p></bio><email xlink:type="simple">alkhovsky@cmd.su</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Центральный научноисследовательский институт эпидемиологии» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology of Rospotrebnadzor</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФБУН «Центральный научноисследовательский институт эпидемиологии» Роспотребнадзора; Институт вирусологии имени Д.И. Ивановского ФГБУ «НИЦЭМ им. Н.Ф. Гамалеи» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology of Rospotrebnadzor;  D.I. Ivanovsky Institute of Virology of N.F. Gamaleya National Research Center for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФБУН «Центральный научноисследовательский институт эпидемиологии» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology of Rospotrebnadzor; Moscow Institute of Physics and Technology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФБУН «Центральный научноисследовательский институт эпидемиологии» Роспотребнадзора; Московский физикотехнический институт</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology of Rospotrebnadzor</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФБУН «Центральный научноисследовательский институт эпидемиологии» Роспотребнадзора; Медикобиологический университет инноваций и непрерывного образования ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Epidemiology of Rospotrebnadzor; Medical and Biological University of Innovation and Continuing Education of the Federal Medical Biophysical Center named after A.I. Burnazyan FMBA of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>09</day><month>09</month><year>2026</year></pub-date><volume>25</volume><issue>4</issue><fpage>4</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Акимкин В.Г., Львов Д.К., Пшеничная Н.Ю., Музыка А.Д., Хафизов К.Ф., Роев Г.В., Аглетдинов З.R., Плоскирева А.А., Морозкин Е.С., Черкашина А.С., Черкашин Е.А., Гасанов Г.А., Есьман А.С., Альховский С.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Акимкин В.Г., Львов Д.К., Пшеничная Н.Ю., Музыка А.Д., Хафизов К.Ф., Роев Г.В., Аглетдинов З., Плоскирева А.А., Морозкин Е.С., Черкашина А.С., Черкашин Е.А., Гасанов Г.А., Есьман А.С., Альховский С.В.</copyright-holder><copyright-holder xml:lang="en">Akimkin V.G., Lvov D.K., Pshenichnaya N.Y., Muzyka A.D., Khafizov K.F., Roev G.V., Agletdinov M.R., Ploskireva A.A., Morozkin E.S., Cherkashina A.S., Cherkashin E.A., Gasanov G.A., Esman A.S., Alkhovsky S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/2487">https://www.epidemvac.ru/jour/article/view/2487</self-uri><abstract><p>Актуальность. В апреле 2026 года на экспедиционном судне MV Hondius зарегистрирована вспышка хантавирусной инфекции, вызванной вирусом Андес (Orthohantavirus andesense), которая приобрела международное значение в связи с перемещением пассажиров и членов экипажа через несколько стран. Вирус Андес является единственным хантавирусом, для которого доказана возможность ограниченной передачи от человека к человеку, что делает вспышки в замкнутых коллективах особенно значимыми с точки зрения биобезопасности. Цель. Проанализировать обстоятельства вспышки хантавирусной инфекции на судне MV Hondius, оценить эпидемиологические и геномные характеристики возбудителя, а также определить уроки для системы региональной и международной биобезопасности. Материалы и методы. Проведён анализ данных эпидемиологического расследования, предоставленных ВОЗ и национальными органами здравоохранения. Геномное секвенирование выполнено с использованием метагеномного подхода, SISPA и гибридизационного обогащения. Филогенетический анализ проведён методом максимального правдоподобия с использованием: IQ-TREE 3. Для обмена геномными данными использована база Pathoplexus. Результаты и обсуждение. Всего выявлено 13 случаев (из них 11 лабораторно подтверждённых, 2 вероятных), зарегистрировано 3 летальных исхода. Эпидемиологическое расследование указывает на первичное зоонозное инфицирование индексного пациента до посадки на судно с последующей ограниченной передачей вируса от человека к человеку. Геномный анализ подтвердил высокую идентичность вирусных последовательностей у заболевших, что свидетельствует о единичном заносе. Филогенетически штамм относится к известной южноамериканской линии ANDV, без признаков появления нового варианта с повышенной изменчивостью. Выявлены различия в приверженности вакцинации между специальностями врачей и категориями пациентов. Выводы. Вспышка на судне MV Hondius демонстрирует, что редкие зоонозные патогены с ограниченной способностью к передаче от человека к человеку могут создавать сложные международные эпидемические ситуации. Необходимы ранняя клиническая диагностика, санитарно-карантинные меры, длительное наблюдение за контактными лицами (до 42 дней), оперативный международный обмен геномными данными и включение геномного секвенирования в обязательный протокол расследования вспышек.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. In April 2026, an outbreak of hantavirus infection caused by Andes virus (Orthohantavirus andesense) was reported on the expedition vessel MV Hondius, which had departed from the port of Ushuaia, Argentina, on 1 April 2026. Clinical symptoms in the first affected passenger appeared on 6 April, and the patient died on board the vessel on 11 April. In the following weeks, severe cases were identified among passengers and crew members after some individuals had disembarked and subsequently travelled through several countries. Aim. To assess the epidemiological and genomic characteristics of the outbreak and identify lessons for biosafety systems. Materials and Methods. We analyzed data from the epidemiological investigation provided by WHO and national health authorities. Genomic sequencing was performed using metagenomic approaches, SISPA, and hybridization enrichment. Phylogenetic analysis was conducted using the maximum likelihood method in IQ-TREE 3. Results and Discussion. Following outbreak investigation and diagnostic testing of patients in different countries, a total of 13 cases of infection were identified including 11 laboratory-confirmed cases, 2 probable cases, and 3 deaths. The epidemiological investigation suggests primary zoonotic infection of the index patient before boarding the vessel in an endemic area of southern Argentina, followed by limited person-to-person transmission on board. Genomic analysis demonstrated a high degree of identity among viral sequences obtained from affected individuals, which is consistent with a single introduction followed by subsequent human-to-human transmission. Conclusions. The hantavirus outbreak on board MV Hondius represents an important example of an epidemiologically significant event in which a zoonotic pathogen with limited capacity for person-to-person transmission occurred within a closed international community. This event highlights the importance of early clinical diagnosis, sanitary and quarantine measures for contact persons, and rapid international exchange of genomic data to ensure biosafety during epidemic events caused by emerging, rare, or genetically altered pathogens.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Andes virus</kwd><kwd>Orthohantavirus andesense</kwd><kwd>хантавирусный кардиопульмональный синдром</kwd><kwd>MV Hondius</kwd><kwd>геномный эпиднадзор</kwd><kwd>биобезопасность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Andes virus</kwd><kwd>Orthohantavirus andesense</kwd><kwd>hantavirus cardiopulmonary syndrome</kwd><kwd>MV Hondius</kwd><kwd>genomic surveillance</kwd><kwd>biosafety</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Львов Д.К. Геморрагическая лихорадка с почечным синдромом. В кн.: Львов Д.К., ред. Руководство по вирусологии: Вирусы и вирусные инфекции человека и животных. М.: МИА; 2013. с. 797–802.</mixed-citation><mixed-citation xml:lang="en">Lvov DK. Hemorrhagic fever with renal syndrome. In: Lvov DK, editor. Manual of Virology: Viruses and Viral Infections in Humans and Animals. Moscow: MIA; 2013. p. 797802. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Львов Д.К. Хантавирусный кардиопульмональный синдром. В кн.: Львов Д.К., ред. Руководство по вирусологии: Вирусы и вирусные инфекции человека и животных. М.: МИА; 2013. с. 802–804.</mixed-citation><mixed-citation xml:lang="en">Lvov DK. Hantavirus cardiopulmonary syndrome. In: Lvov DK, editor. Manual of Virology: Viruses and Viral Infections in Humans and Animals. Moscow: MIA; 2013. p. 802–4. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Young JC, Mills JN, Enria DA, Dolan NE, Khan AS, Ksiazek TG. New World hantaviruses. Br Med Bull. 1998;54(3):659–73. doi:10.1093/oxfordjournals.bmb.a011718</mixed-citation><mixed-citation xml:lang="en">Young JC, Mills JN, Enria DA, Dolan NE, Khan AS, Ksiazek TG. New World hantaviruses. Br Med Bull. 1998;54(3):659–73. doi:10.1093/oxfordjournals.bmb.a011718</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">López N, Padula P, Rossi C, Lázaro ME, Franze-Fernández MT. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology. 1996;220(1):223–6. doi:10.1006/VIRO.1996.0305</mixed-citation><mixed-citation xml:lang="en">López N, Padula P, Rossi C, Lázaro ME, Franze-Fernández MT. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology. 1996;220(1):223–6. doi:10.1006/VIRO.1996.0305</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Padula P, Della Valle MG, Alai MG, Cortada P, Villagra M, Gianella A. Andes virus and first case report of Bermejo virus causing fatal pulmonary syndrome. Emerg Infect Dis. 2002;8(4):437–9. doi:10.3201/eid0804.010300</mixed-citation><mixed-citation xml:lang="en">Padula P, Della Valle MG, Alai MG, Cortada P, Villagra M, Gianella A. Andes virus and first case report of Bermejo virus causing fatal pulmonary syndrome. Emerg Infect Dis. 2002;8(4):437–9. doi:10.3201/eid0804.010300</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Khan AS, Khabbaz RF, Armstrong LR, Holman RC, Bauer SP, Graber J, et al. Hantavirus pulmonary syndrome: The first 100 US cases. J Infect Dis. 1996;173(6):1297–303. doi:10.1093/INFDIS/173.6.1297</mixed-citation><mixed-citation xml:lang="en">Khan AS, Khabbaz RF, Armstrong LR, Holman RC, Bauer SP, Graber J, et al. Hantavirus pulmonary syndrome: The first 100 US cases. J Infect Dis. 1996;173(6):1297–303. doi:10.1093/INFDIS/173.6.1297</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez VP, Bellomo C, San Juan J, Pinna D, Forlenza R, Elder M, et al. Person-to-person transmission of Andes virus. Emerg Infect Dis. 2005;11(12):1848–53. doi:10.3201/EID1112.050501</mixed-citation><mixed-citation xml:lang="en">Martinez VP, Bellomo C, San Juan J, Pinna D, Forlenza R, Elder M, et al. Person-to-person transmission of Andes virus. Emerg Infect Dis. 2005;11(12):1848–53. doi:10.3201/EID1112.050501</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Vitek CR, Breiman RF, Ksiazek TG, Rollin PE, McLaughlin JC, Umland ET, et al. Evidence against person-to-person transmission of hantavirus to health care workers. Clin Infect Dis. 1996;22(5):824–6.</mixed-citation><mixed-citation xml:lang="en">Vitek CR, Breiman RF, Ksiazek TG, Rollin PE, McLaughlin JC, Umland ET, et al. Evidence against person-to-person transmission of hantavirus to health care workers. Clin Infect Dis. 1996;22(5):824–6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Valdebenito C, Calvo M, Vial C, Mansilla R, Marco C, Palma RE, et al. Person-to-person household and nosocomial transmission of andes hantavirus, Southern Chile, 2011. Emerg Infect Dis. 2014;20(10):1629–36. doi:10.3201/eid2010.140353</mixed-citation><mixed-citation xml:lang="en">Martinez-Valdebenito C, Calvo M, Vial C, Mansilla R, Marco C, Palma RE, et al. Person-to-person household and nosocomial transmission of Andes hantavirus, Southern Chile, 2011. Emerg Infect Dis. 2014;20(10):1629–36. doi:10.3201/eid2010.140353</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology. 1998;241(2):323–30. doi:10.1006/viro.1997.8976</mixed-citation><mixed-citation xml:lang="en">Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology. 1998;241(2):323–30. doi:10.1006/viro.1997.8976</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bradfute SB, Calisher CH, Klempa B, Klingström J, Kuhn JH, Laenen L, et al. ICTV Virus Taxonomy Profile: Hantaviridae 2024. J Gen Virol. 2024;105(4). doi:10.1099/JGV.0.001975</mixed-citation><mixed-citation xml:lang="en">Bradfute SB, Calisher CH, Klempa B, Klingström J, Kuhn JH, Laenen L, et al. ICTV Virus Taxonomy Profile: Hantaviridae 2024. J Gen Virol. 2024;105(4). doi:10.1099/JGV.0.001975</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lednicky JA. Hantaviruses. A short review. Arch Pathol Lab Med. 2003;127(1):30–5. doi:10.1043/0003-9985(2003)127&lt;30:&gt;2.0.CO;2</mixed-citation><mixed-citation xml:lang="en">Lednicky JA. Hantaviruses. A short review. Arch Pathol Lab Med. 2003;127(1):30–5. doi:10.1043/0003-9985(2003)127&lt;30:&gt;2.0.CO;2</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Simmons JH, Riley LK. Hantaviruses: an overview. Comp Med. 2002;52(2):97–110.</mixed-citation><mixed-citation xml:lang="en">Simmons JH, Riley LK. Hantaviruses: an overview. Comp Med. 2002;52(2):97–110.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson KM. Hantaviruses: history and overview. Curr Top Microbiol Immunol. 2001;256:1–14.</mixed-citation><mixed-citation xml:lang="en">Johnson KM. Hantaviruses: history and overview. Curr Top Microbiol Immunol. 2001;256:1–14.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ткаченко Е.А., Дзагурова Т.К., Ткаченко П.Е. Хантавирусы: экология, молекулярная биология, морфология, патогенез и диагностика хантавирусных инфекций. Молекулярная медицина. 2009;(5):36–41.</mixed-citation><mixed-citation xml:lang="en">Tkachenko EA, Dzagurova TK, Tkachenko PE. Hantaviruses: ecology, molecular biology, morphology, pathogenesis and diagnostics of hantavirus infections. Molekulyarnaya Meditsina. 2009;(5):36–41. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lvov DK, Shchelkanov MY, Alkhovsky SV, Deryabin PG. Zoonotic viruses of Northern Eurasia: Taxonomy and ecology. London: Academic Press, Elsevier; 2015. 440 p.</mixed-citation><mixed-citation xml:lang="en">Lvov DK, Shchelkanov MY, Alkhovsky SV, Deryabin PG. Zoonotic viruses of Northern Eurasia: Taxonomy and ecology. London: Academic Press, Elsevier; 2015. 440 p.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yashina L, Mishin V, Zdanovskaya N, Schmaljohn C, Ivanov L. A newly discovered variant of a hantavirus in Apodemus peninsulae, far Eastern Russia. Emerg Infect Dis. 2001;7(5):912–3. doi:10.3201/eid0705.017530</mixed-citation><mixed-citation xml:lang="en">Yashina L, Mishin V, Zdanovskaya N, Schmaljohn C, Ivanov L. A newly discovered variant of a hantavirus in Apodemus peninsulae, far Eastern Russia. Emerg Infect Dis. 2001;7(5):912–3. doi:10.3201/eid0705.017530</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Yashina LN, Abramov SA, Gutorov VV, Dupal TA, Krivopalov AV, Panov VV, et al. Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia. Vector Borne Zoonotic Dis. 2010;10(6):585–91. doi:10.1089/vbz.2009.0154</mixed-citation><mixed-citation xml:lang="en">Yashina LN, Abramov SA, Gutorov VV, Dupal TA, Krivopalov AV, Panov VV, et al. Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia. Vector Borne Zoonotic Dis. 2010;10(6):585–91. doi:10.1089/vbz.2009.0154</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Astorga F, Escobar LE, Poo-Muñoz D, Escobar-Dodero J, Rojas-Hucks S, Alvarado-Rybak M, et al. Distributional ecology of Andes hantavirus: A macroecological approach. Int J Health Geogr. 2018;17(1). doi:10.1186/s12942-018-0142-z</mixed-citation><mixed-citation xml:lang="en">Astorga F, Escobar LE, Poo-Muñoz D, Escobar-Dodero J, Rojas-Hucks S, Alvarado-Rybak M, et al. Distributional ecology of Andes hantavirus: A macroecological approach. Int J Health Geogr. 2018;17(1). doi:10.1186/s12942-018-0142-z</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Medina RA, Torres-Perez F, Galeno H, Navarrete M, Vial PA, Palma RE, et al. Ecology, genetic diversity, and phylogeographic structure of Andes virus in humans and rodents in Chile. J Virol. 2009;83(6):2446–59. doi:10.1128/JVI.01057-08</mixed-citation><mixed-citation xml:lang="en">Medina RA, Torres-Perez F, Galeno H, Navarrete M, Vial PA, Palma RE, et al. Ecology, genetic diversity, and phylogeographic structure of Andes virus in humans and rodents in Chile. J Virol. 2009;83(6):2446–59. doi:10.1128/JVI.01057-08</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Carbajo AE, Vera C, Gonzalez PL. Hantavirus reservoir Oligoryzomys longicaudatus spatial distribution sensitivity to climate change scenarios in Argentine Patagonia. Int J Health Geogr. 2009;8:44. doi:10.1186/1476-072X-8-44</mixed-citation><mixed-citation xml:lang="en">Carbajo AE, Vera C, Gonzalez PL. Hantavirus reservoir Oligoryzomys longicaudatus spatial distribution sensitivity to climate change scenarios in Argentine Patagonia. Int J Health Geogr. 2009;8:44. doi:10.1186/1476-072X-8-44</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Andreo V, Glass G, Shields T, Provensal C, Polop J. Modeling potential distribution of Oligoryzomys longicaudatus, the Andes virus (Genus: Hantavirus) reservoir, in Argentina. Ecohealth. 2011;8(3):332–48. doi:10.1007/s10393-011-0719-5</mixed-citation><mixed-citation xml:lang="en">Andreo V, Glass G, Shields T, Provensal C, Polop J. Modeling potential distribution of Oligoryzomys longicaudatus, the Andes virus (Genus: Hantavirus) reservoir, in Argentina. Ecohealth. 2011;8(3):332–48. doi:10.1007/s10393-011-0719-5</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pizarro E, Navarrete M, Mendez C, Zaror L, Mansilla C, Tapia M, et al. Immunocytochemical and ultrastructural evidence supporting that Andes hantavirus (ANDV) is transmitted person-to-person through the respiratory and/or salivary pathways. Front Microbiol. 2020;10:2992. doi:10.3389/FMICB.2019.02992</mixed-citation><mixed-citation xml:lang="en">Pizarro E, Navarrete M, Mendez C, Zaror L, Mansilla C, Tapia M, et al. Immunocytochemical and ultrastructural evidence supporting that Andes hantavirus (ANDV) is transmitted person-to-person through the respiratory and/or salivary pathways. Front Microbiol. 2020;10:2992. doi:10.3389/FMICB.2019.02992</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Markotić A. Presence of Andes orthohantavirus in human body fluids. Lancet Infect Dis. 2024;24(7):674–6. doi:10.1016/S1473-3099(24)00172-5</mixed-citation><mixed-citation xml:lang="en">Markotić A. Presence of Andes orthohantavirus in human body fluids. Lancet Infect Dis. 2024;24(7):674–6. doi:10.1016/S1473-3099(24)00172-5</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez VP, Di Paola N, Alonso DO, Pérez-Sautu U, Bellomo CM, Iglesias AA, et al. «Super-Spreaders» and person-to-person transmission of Andes virus in Argentina. N Engl J Med. 2020;383(23):2230–41. doi:10.1056/NEJMOA2009040</mixed-citation><mixed-citation xml:lang="en">Martínez VP, Di Paola N, Alonso DO, Pérez-Sautu U, Bellomo CM, Iglesias AA, et al. «Super-Spreaders» and person-to-person transmission of Andes virus in Argentina. N Engl J Med. 2020;383(23):2230–41. doi:10.1056/NEJMOA2009040</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wong TKF, Ly-Trong N, Ren H, Demotte P, Baños H, Roger AJ, et al. IQ-TREE 3: phylogenomic inference software using complex evolutionary models. Mol Biol Evol. 2026;43(5). doi:10.1093/molbev/msag117</mixed-citation><mixed-citation xml:lang="en">Wong TKF, Ly-Trong N, Ren H, Demotte P, Baños H, Roger AJ, et al. IQ-TREE 3: phylogenomic inference software using complex evolutionary models. Mol Biol Evol. 2026;43(5). doi:10.1093/molbev/msag117</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Pathoplexus. SeqSet: Andes. 2026. doi:10.62599/PP_SS_2476.1. https://pathoplexus.org/seqsets/PP_SS_2476.1</mixed-citation><mixed-citation xml:lang="en">Pathoplexus. SeqSet: Andes. 2026. doi:10.62599/PP_SS_2476.1. Available at: https://pathoplexus.org/seqsets/PP_SS_2476.1. Accessed: 22 May 2026.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
