References

epidemiology

Эпидемиология и Вакцинопрофилактика

Epidemiology and Vaccinal Prevention

2073-30462619-0494

«Numicom» LLC

10.31631/2073-3046-2017-16-2-36-43

epidemiology-253

Research Article

ИНФОРМАЦИЯ ЕРБ ВОЗ

WHO/EUROPE INFORMATION

Фенотипическая характеристика и динамика чувствительности к антибактериальным препаратам российских штаммов Haemophilus influenzae (2004 - 2016 гг.)

Phenotypic Characteristics and the Susceptibility of Haemophilus influenzae to the Antimicrobial Agents in Russia (2004 - 2016)

Королева

М. А.

Koroleva

M. A.

korolevamaria389@gmail.com

Королева

И. С.

Koroleva

I. S.

noemail@neicon.ru

Грубер

И. М.

Gruber

I. M.

noemail@neicon.ru

Черкасова

Л. С.

Cherkasova

L. S.

noemail@neicon.ru

ФБУН «ЦНИИ эпидемиологии» РоспотребнадзораРоссияFederal Budget Institution of Science «Central Research Institute of Epidemiology» of The Federal Service on Customers Rights Protection and Human Well-being SurveillanceRussian Federation

ФГБНУ «НИИ вакцин и сывороток им. И.И. Мечникова» РАНРоссияFederal State Budget Institution of Science «Research Institute of Vaccines and Sera», Russian Academy of Medical SciencesRussian Federation

2017

20042017

1623643

2017

Королева М.А., Королева И.С., Грубер И.М., Черкасова Л.С.

Koroleva M.A., Koroleva I.S., Gruber I.M., Cherkasova L.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epidemvac.ru/jour/article/view/253

Цель. Изучение фенотипических свойств и динамики чувствительности к антибактериальным препаратам российских инвазивных штаммов H. influenzae. Материалы и методы. Изучено 89 российских штаммов H. influenzae за 13-летний период (2004 -2016 гг.). Исследовали метаболическую, ферментативную и пенициллиназную активность, а также биотиповую характеристику штаммов H. influenzae. Устанавливали чувствительность H.influenzae к ряду антибактериальных препаратов. Результаты. Большинство штаммов H. influenzae отнесены к серотипу b (95,5%). Определены биотипы исследуемых штаммов: II (69,7%), VII (16,9%), I (13,5%). Устойчивые к ампициллину штаммы составили 10,1%. Все они продуцировали фермент бета-лактамазу. Заключение. В популяции российских инвазивных штаммов H. influenzae ампицилин-резистентные штаммы составили 10,1%. Определен механизм резистентности устойчивых к ампициллину штаммов, а именно, продукция фермента бета-лактамазы.

The aim. The study of phenotypic characteristics and dynamics of sensitivity to antibiotics Russian invasive strains H. influenzae. Materials and methods. Studied 89 Russian invasive strains H. influenzae for the period 13-year period (2004 - 2016). To study metabolic, enzymatic activity and beta-lactamase and biotype characteristics H. influenzae strains. Studied H. influenzae sensitivity to antibiotics. Results. Most strains related H. influenzae serotype b (86,1%), biotype II (69,7%), VII (16,9%), I (13,5%). Ampicillin-resistant strains accounted for 10.1%. All of them produced the enzyme beta-lactamase. Conclusion. The population of the Russian invasive ampicillin-resistant H. influenzae strains accounted for 10.1%. The mechanism of resistance to ampicillin is the production of the enzyme beta-lactamase.

гемофильная инфекциягемофильная палочкаменингитрезистентность к антибактериальным препаратамHaemophilus influenzaemeningitisantimicrobial resistance

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The authors declare that there are no conflicts of interest present.