epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2017-16-5-87-97epidemiology-327Research ArticleОБЗОРНАЯ СТАТЬЯМенингококковое носительство: эпидемиология, возбудитель, формирование иммунной защитыMeningococcal Carriage: Epidemiology, Causative Agent, Inducing of Immune ProtectionКостюковаН. Н.KostyukovaN. N.nathakos@mail.ruБехалоВ. А.BekhaloV. A.bekhalo@gamaleya.orgФГБУ «НИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи» Минздрав РоссииРоссияFederal State Budgetary Institution «National Research Center of Epidemiology and Microbiology of N . F. Gamaleya» Ministry of Healthcare of Russian FederationRussian Federation2017201020171658797Copyright © Костюкова Н.Н., Бехало В.А., 20172017Костюкова Н.Н., Бехало В.А.Kostyukova N.N., Bekhalo V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/327

Дан обзор современных представлений о менингококковом носительстве. Рассматриваются вопросы эпидемиологии менингококкового носительства, фенотипические и генетические особенности носительских штаммов, подчеркивается генетическая неоднородность циркулирующей популяции, реализующаяся в различной степени патогенности носительских штаммов и их разной эпидемиологической значимости. Представлены современные данные об иммунизирующем действии носительства, вызывающего общий и местный (мукозный) защитный ответ к генерализованным формам и носительству. Кратко описаны принципы снижения носительства.

A review of the actual problems concerning the meningococcal carriage is presented. The review includes: the epidemiological features of meningococcal carriage, the phenotyping and genotyping characteristics of the carriage strains, the modern models of the carriage, the general and local (mucosal) immune protection induced by the carriage. The significance of genetic and virulence heterogenicity of carriage meningococcal population is underlined.

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The authors declare that there are no conflicts of interest present.