epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2018-17-5-106-110epidemiology-584Research ArticleПРАКТИЧЕСКИЕ АСПЕКТЫ ЭПИДЕМИОЛОГИИ И ВАКЦИНОПРОФИЛАКТИКИPRACTICAL ASPECTS OF EPIDEMIOLOGY AND VACCINE PREVENTIONВПЧ-ассоциированные заболевания в практике онкопроктологаHPV-Associated Malignancy in the Practice of Colorectal Cancer SpecialistГордеевС. С.GordeevS. S.

Сергей Сергеевич Гордеев – кандидат медицинских наук, врач-онколог хирургического отделения № 3 (проктологическое) НМИЦ онкологии им. Н.Н.Блохина МР, ответственный секретарь Российского общества специалистов по колоректальному раку.

+7-910-450-12-13

Sergey S. Gordeev – Cand. Sci. (Med.), oncologist, surgical department № 3 (proctological).

Moscow, +7-910-450-12-13

ss.netoncology@gmail.comФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN. N. Blokhin National Medical Research Centre of oncologyRussian Federation201823102018175106110Copyright © Гордеев С.С., 20182018Гордеев С.С.Gordeev S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/584

В статье рассматривается история открытия связи вируса папилломы человека (ВПЧ) с развитием онкологических заболеваний, анализируются факторы риска, патогенез, методы диагностики, лечения и профилактики анальной интраэпителиальной неоплазии (АИН) и плоскоклеточного рака анального канала (ПРАК). Относясь к редким, эти заболевания представляю серьезную угрозу здоровью для людей, входящих в группы высокого риска (ВИЧ-инфицированные, страдающие ВПЧ-ассоциированными заболеваниями, лица, практикующие анальный половой контакт, получающих иммуносупрессивную терапию). Необходима кооперация врачей различных специальностей для разработки эффективной системы профилактики ВПЧ-ассоциированных проктологических заболеваний. АИН не имеет стандартизированных методов диагностики и лечения. Для профилактики ВПЧассоциированных проктологических заболеваний может быть эффективна вакцинация, однако требуется более широкое изучение распространённости типов вируса в российской популяции. Данные первых исследований говорят о необходимости использования поливалентных вакцин в России.

The history of association between HPV and cancer, risk factors, pathogenesis, diagnostics, treatment and prophylaxis of anal intraelithelial neoplasia (AIN) and squamous-cell anal cancer are discussed in this article. Although these conditions are rare, they may become some of the main health hazards in certain groups of patients, such as HIV-infected patients, patients with history of other HPV-related malignancies, patients practicing anal sexual intercourse and patients receiving systemic immunosuppressive therapy. A collaboration of different specialists is necessary in order to develop effective prophylactic measures for HPV-associated malignancies of anal region. There are no estabilished methods for AIN treatment. The use of ointments and local destruction are the most researched treatment methods. Vaccination is already developed as a prophylactic measure. However, a more thorogh research of HPV types in russian population is necessary prior to its wide implementation. Preliminary data favors the use of polivalent vaccines in russian population.

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The authors declare that there are no conflicts of interest present.