<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">epidemiology</journal-id><journal-title-group><journal-title xml:lang="ru">Эпидемиология и Вакцинопрофилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Epidemiology and Vaccinal Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-3046</issn><issn pub-type="epub">2619-0494</issn><publisher><publisher-name>«Numicom» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31631/2073-3046-2019-18-4-34-40</article-id><article-id custom-type="elpub" pub-id-type="custom">epidemiology-801</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Характеристика эпидемиологической ситуации по кори в период элиминации в Республике Молдова</article-title><trans-title-group xml:lang="en"><trans-title>Characteristics of the Epidemiological Situation of Measles in the Period of its Elimination in Republic of Moldova</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельник</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnik</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анатолий Алексеевич Мельник – к.м.н., заведующий отделом эпидемиологического надзора за вакциноуправляемыми инфекциями</p><p>мун. Кишинев, ул. Георгия Асаки 67А. +373 22 574 674</p></bio><bio xml:lang="en"><p>Anatolie A. Melnic – Cand. Sci. (Med.), head of department medical doctor, head of department Epidemiological Surveillance of Vaccine Preventive diseases</p><p>67A, Gheorghe Asachi str. MD2028, Chisinau. +373 22 574 674</p></bio><email xlink:type="simple">anatolie.melnic@ansp.md</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Букова</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Bukova</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктория Емилиановна Букова  – д.м.н., профессор, главный научный сотрудник </p><p>мун. Кишинев, ул. Георгия Асаки 67А. +373  22  574  587</p></bio><bio xml:lang="en"><p>Victoria E. Bucova – Dr. Sci. (Med.), professor, chief researcher</p><p>67A, Gheorghe Asachi str. MD2028, Chisinau. +373 22 574 587</p></bio><email xlink:type="simple">victoria.bucov@ansp.md</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цуркан</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsurcan</surname><given-names>L. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лаура Пантелеймоновна Цуркан  – к.м.н., врач-эпидемиолог отдела эпидемиологического надзора за вакциноуправлямыми инфекциями </p><p>2028 мун. Кишинев, ул. Георгия Асаки 67А. +373 22 574 569</p></bio><bio xml:lang="en"><p>Laura P. Tsurcan  – Cand. Sci. (Med.), doctor-epidemiologist in department of Vaccine Preventive diseases Division</p><p>67A, Gheorghe Asachi str. MD2028, Chisinau. +373 22 574 569</p></bio><email xlink:type="simple">laura.turcan@ansp.md</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фуртунэ</surname><given-names>Н. И</given-names></name><name name-style="western" xml:lang="en"><surname>Furtuna</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николай Иванович Фуртунэ – врач эпидемиолог</p><p>мун. Кишинев, ул. Георгия Асаки 67А. +373 22 574 503</p></bio><bio xml:lang="en"><p>Nicolae I. Furtuna – doctor-epidemiologist</p><p>67A, Gheorghe Asachi str. MD2028, Chisinau. +373 22 574 503 </p></bio><email xlink:type="simple">nicolae.furtuna@ansp.md</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальное агентство общественного здоровья</institution><country>Молдова</country></aff><aff xml:lang="en"><institution>National Agency for Public Health</institution><country>Moldova, Republic of</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>12</day><month>09</month><year>2019</year></pub-date><volume>18</volume><issue>4</issue><fpage>34</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мельник А.А., Букова В.Е., Цуркан Л.П., Фуртунэ Н.И., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Мельник А.А., Букова В.Е., Цуркан Л.П., Фуртунэ Н.И.</copyright-holder><copyright-holder xml:lang="en">Melnik A.A., Bukova V.E., Tsurcan L.P., Furtuna N.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epidemvac.ru/jour/article/view/801">https://www.epidemvac.ru/jour/article/view/801</self-uri><abstract><p>Актуальность. Корь продолжает оставаться одной из приоритетных задач здравоохранения во всем мире, учитывая высокую контагиозность, все еще широкое распространение, тяжесть заболевания и осложнений. Способствует распространению инфекции высокая степень миграции населения, т.е. глобальная циркуляция вируса кори, изменение клиники и позднее диагностирование, недостаточный охват иммунизацией. Цель статьи – анализ заболеваемости корью в Республике Молдова в 2000– 2018 гг. и особенности эпидемического процесса. Материалы и методы. Использовались статистические данные о заболеваемости корью и охвате иммунизацией в 2000–2018 гг. Подробному разбору подвергнуты 340 случаев кори, зарегистрированные в стране в 2018 г. Результаты и обсуждение. Отмечается уменьшение охвата вакцинацией против кори до 87,1% в 2017 г. В том же году охват первой ревакцинацией в 6–7 лет – 92,4% и второй в 14–15 лет – 94,9%, что недостаточно для поддержания эпидемиологического благополучия. Наблюдаются территориальные различия в уровне охвата вакцинацией. В 2018 г. завозные случаи кори были из Украины – 62,5%, из России – 25,0% и 12,5% – из Румынии. Были зарегистрированы как единичные случаи кори (14 случаев), так и эпидемические очаги или вспышки (7 очагов вспышек), с вовлечением от 2 до 252 заболевших. Самая крупная вспышка кори в 2018 г. началась среди не привитых лиц, отдыхавших в неавторизованном лагере религиозной направленности. Средний возраст заболевших составляет 14 лет, а при вспышках со значительным количеством заболевших (9 и более) – в пределах 7,9–14,9 лет. В возрастной структуре заболевших преобладают дети от 1 до 10 лет (66,1%), дети до года составляли 8,2%, подростки – 17,5% и взрослые – 8,2%. Среди заболевших одну дозу коревой вакцины получили всего 11,0%, две дозы - 3,6% из подлежащих возрастных групп. Причиной является отказ от вакцинации по религиозным соображениям. В 196 случаях (57,6%) диагноз был подтвержден лабораторными методами, а в остальных 144 (42,4%) – клинико-эпидемиологически. Выводы. Корь остается детской инфекцией, но случаи заболевания встречаются среди подростков (17,5%) и взрослых (8,2%). Неравномерность охвата вакцинацией в целом по стране, низкий уровень ответственности населения, повышенная заболеваемость корью в соседних странах, высокий уровень миграции населения являются факторами риска в отношении завоза и распространения кори.</p></abstract><trans-abstract xml:lang="en"><p>Relevance Measles continues to be one of the priorities of health care worldwide, due to it high contagiosity, still widespread, severity of the disease and complications. A high degree of population migration contributes to the spread of infection, i.e. global measles virus circulation, clinical change and late diagnosis, inadequate immunization coverage. Aim. Analysis of measles incidence in the Republic of Moldova in 2000–2018. and features of the epidemic process. Materials and Methods. Statistics on measles incidence and immunization coverage in 2000–2018 were used. 340 cases of measles registered in the country in 2018 were subjected to a detailed analysis Results There is a decrease in measles vaccination coverage, in 2017–87.1%. In the same year, the coverage with the first revaccination at 6–7 years was 92.4% and the second at 14–15 years is 94.9%, which is not enough to maintain epidemiological well-being. There are territorial differences in vaccination coverage. In 2018, imported cases of measles were in 62.5% from Ukraine, 25.0% from Russia and 12.5% from Romania. There have been isolated measles cases (14), and epidemic foci or outbreaks (7), with from 2 to 252 cases of measles. The largest measles outbreak in 2018 was registered among those who rest in a religious camp unvaccinated against measles. The average age of the diseased is 14 years, and in outbreaks with a significant number of cases (9 and more) within 7.9–14.9 years. In the age structure of the diseased, children from 1 to 10 years old prevail (66.1%), children under one year old make up 8,2%, teenagers 17,5% and adults 8.2%. Only 11.0% received one dose of measles vaccine, and 3.6% of the relevant age groups received two doses of vaccine. The reason is the refusal of vaccination for religious motive. In 196 (57.6%) cases, the diagnosis was confirmed by laboratory methods, and in the remaining 144 (42.4%) by clinical and epidemiological data. Conclusions Measles remains a childhood infection, but cases of the disease occur among adolescents (17.5%) and adults (8.2%). The uneven of vaccination coverage throughout the country, the low level of responsibility of the population, the increased incidence of measles in neighboring countries, the high level of population migration are risk factors for the importation and spread of measles.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>корь</kwd><kwd>заболеваемость</kwd><kwd>надзор</kwd><kwd>иммунизация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>measles</kwd><kwd>incidence</kwd><kwd>surveillance</kwd><kwd>immunization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dabbagh Aatel M.K., Dumolard L., Gacic-Dobo M., et al. Progress Toward Regional Measles Elimination – Worldwide, 2000–2016 // MMWR Morb Mortal Wkly Rep. 2017. Vol. 66, N 42. P. 1148–1153.</mixed-citation><mixed-citation xml:lang="en">Dabbagh Aatel MK, Dumolard L, Gacic-Dobo M., et al. Progress Toward Regional Measles Elimination – Worldwide, 2000–2016.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Guerra F.M., Bolotin S., Lim G., et al. The basic reproduction number (R0 ) of measles: a systematic review // Lancet Infect Dis. 2017. Vol. 17, N 12. P. e420–e428.</mixed-citation><mixed-citation xml:lang="en">Guerra FM, Bolotin S, Lim G, et al. The basic reproduction number (R0 ) of measles: a systematic review. Lancet Infect Dis. 2017;17(12):e420–e428.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lancella L., Di Camillo C., Vittucci A.C., et al. Measles lessons in an anti-vaccination era: public health is a social duty, not a political option // Ital J Pediatr. 2017. Vol. 43, N 1. P. 102</mixed-citation><mixed-citation xml:lang="en">Lancella L, Di Camillo C, Vittucci AC, et al. Measles lessons in an anti-vaccination era: public health is a social duty, not a political option. Ital J Pediatr. 2017;43(1):102</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Santibanez S., Hübschen J.M., Ben Mamou M.C., et al. Molecular surveillance of measles and rubella in the WHO European Region: new challenges in the elimination phase // Clin Microbiol and Infect. 2017. N 23. P. 516–523.</mixed-citation><mixed-citation xml:lang="en">Santibanez S, Hübschen JM, Ben Mamou MC, et al. Molecular surveillance of measles and rubella in the WHO European Region: new challenges in the elimination phase. Clin Microbiol and Infect. 23(2017):516–523.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bühler S., Lang P., Bally B., et al. Stop measles in Switzerland – The importance of travel medicine // Vaccine. 2017. Vol. 35, N 30. P. 3760–3763.</mixed-citation><mixed-citation xml:lang="en">Bühler S, Lang P, Bally B, et al. Stop measles in Switzerland – The importance of travel medicine. Vaccine. 2017;35(30):3760–3763.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Komabayashi K., Seto J., Tanaka S., et al. The largest measles outbreak, including 38 modified measles and 22 typical measles cases, Yamagata, Japan, 2017 in its elimination era // Jpn J Infect Dis. 2018.</mixed-citation><mixed-citation xml:lang="en">Komabayashi K, Seto J, Tanaka S, et al. The largest measles outbreak, including 38 modified measles and 22 typical measles cases, Yamagata, Japan, 2017 in its elimination era. Jpn J Infect Dis. 2018 Jun 29.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Корь. Всемирная организация здравоохранения (ВОЗ). Доступно по: https://www.who.int/ru/news-room/fact-sheets/detail/measles Ссылка активна на 20 мая 2019.</mixed-citation><mixed-citation xml:lang="en">Measles. WHO. Available at: https://www.who.int/ru/news-room/fact-sheets/detail/measles Accessed: 20 May 2019.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hagan J.E., Kriss J.L., Takashima Y., et al. Progress Toward Measles Elimination – Western Pacific Region, 2013–2017 // MMWR Morb Mortal Wkly Rep. 2018. Vol. 67, N 17. P. 491–495.</mixed-citation><mixed-citation xml:lang="en">Hagan JE, Kriss JL, Takashima Y, et al. Progress Toward Measles Elimination – Western Pacific Region, 2013–2017. MMWR Morb Mortal Wkly Rep. 2018; 67(17):491–495.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Eom H., Park Y., Kim J., et al. Occurrence of measles in a country with elimination status: Amplifying measles infection in hospitalized children due to imported virus // PLoS One. 2018. Vol. 13, N 2. P. e0188957.</mixed-citation><mixed-citation xml:lang="en">Eom H, Park Y, Kim J, et al. Occurrence of measles in a country with elimination status: Amplifying measles infection in hospitalized children due to imported virus. PLoS One. 2018;13(2):e0188957.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lo Vecchio A., Cambriglia M.D., Fedele M., et al. Determinants of low measles vaccination coverage in children living in an endemic area // Eur J Pediatr. 2019. Vol. 178, N 2. P. 243–251.</mixed-citation><mixed-citation xml:lang="en">Lo Vecchio A, Cambriglia MD, Fedele M, et al. Determinants of low measles vaccination coverage in children living in an endemic area. Eur J Pediatr. 2019;178(2):243–251.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Furuse Y., Oshitani H. Global Transmission Dynamics of Measles in the Measles Elimination Era // Viruses. 2017. Vol. 9, N 4. P. pii:E82.</mixed-citation><mixed-citation xml:lang="en">Furuse Y, Oshitani H. Global Transmission Dynamics of Measles in the Measles Elimination Era. Viruses. 2017;9(4):E82.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka-Taya K. Current situation of measles in Japan, 2017 // Uirusu. 2017. Vol. 67, N 1. P. 17–24.</mixed-citation><mixed-citation xml:lang="en">Tanaka-Taya K. Current situation of measles in Japan, 2017. Uirusu. 2017;67(1):17–24. doi: 10.2222/jsv.67.17</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ntirampeba D, Neema I, Kazembe L. Modelling spatio-temporal patterns of disease for spatially misaligned data: An application on measles incidence data in Namibia from 2005–2014 // PLoS One. 2018. Vol. 13, N 8. P. e0201700.</mixed-citation><mixed-citation xml:lang="en">Ntirampeba D, Neema I, Kazembe L. Modelling spatio-temporal patterns of disease for spatially misaligned data: An application on measles incidence data in Namibia from 2005–2014. PLoS One. 2018;13(8):e0201700.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Georgakopoulou T, Horefti E., Vernardaki A, et al. Ongoing measles outbreak in Greece related to the recent European-wide epidemic // Epidemiol Infect. 2018. Vol. 146, N 13. P. 1692–1698.</mixed-citation><mixed-citation xml:lang="en">Georgakopoulou T, Horefti E, Vernardaki A, et al. Ongoing measles outbreak in Greece related to the recent European-wide epidemic. Epidemiol Infect. 2018;146(13):1692– 1698.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bernadou A., Astrugue C., Méchain M., et al. Measles outbreak linked to insufficient vaccination coverage in Nouvelle-Aquitaine Region, France, October 2017 to July 2018 // Euro Surveill. 2018. Vol. 23, N 30.</mixed-citation><mixed-citation xml:lang="en">Bernadou A, Astrugue C, Méchain M, et al. Measles outbreak linked to insufficient vaccination coverage in Nouvelle-Aquitaine Region, France, October 2017 to July 2018. Euro Surveill. 2018;23(30).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Abeev A., Zhylkibayev A., Kamalova D., et al. Epidemiological Outbreaks of Measles Virus in Kazakhstan during 2015 // Jpn J Infect Dis. 2018. Vol. 71, N 5. P. 354–359.</mixed-citation><mixed-citation xml:lang="en">Abeev A, Zhylkibayev A, Kamalova D, et al. Epidemiological Outbreaks of Measles Virus in Kazakhstan during 2015. Jpn J Infect Dis. 2018;71(5):354–359.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Palamara M.A., Visalli G., Picerno I., et al. Measles outbreak from February to August 2017 in Messina, Italy // J Prev Med Hyg. 2018. Vol. 59, N 1. P. E8–E13.</mixed-citation><mixed-citation xml:lang="en">Palamara MA, Visalli G, Picerno I, et al. Measles outbreak from February to August 2017 in Messina, Italy. J Prev Med Hyg. 2018;59(1):E8–E13.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Заболеваемость корью в России в 2018 году увеличилась в 3,5 раза. Regnum. Доступно по: https://regnum.ru/news/2569263.html Ссылка активна на 20 мая 2019.</mixed-citation><mixed-citation xml:lang="en">Available at: https://regnum.ru/news/2569263.html Accessed: 20 May 2019.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Доступно по: https://www.who.int/immunization/diseases/measles/en/ Ссылка активна на 20 мая 2019.</mixed-citation><mixed-citation xml:lang="en">Available at: https://www.who.int/immunization/diseases/measles/en/ Accessed: 20 May 2019.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Доступно по: http://www.euro.who.int/en/media-centre/sections/press-releases/2019/measles-in-europe-record-number-of-both-sick-and-immunized Ссылка активна на 20 мая 2019.</mixed-citation><mixed-citation xml:lang="en">Available at: http://www.euro.who.int/en/media-centre/sections/press-releases/2019/measles-in-europe-record-number-of-both-sick-and-immunized Accessed: 20  May 2019.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Coughlin M.M., Beck A.S., Bankamp B., Rota P.A. Perspective on Global Measles Epidemiology and Control and the Role of Novel Vaccination Strategies // Viruses. 2017. Vol. 9, N 1. P. 11.</mixed-citation><mixed-citation xml:lang="en">Coughlin MM, Beck AS, Bankamp B, Rota PA. Perspective on Global Measles Epidemiology and Control and the Role of Novel Vaccination Strategies. Viruses. 2017;9(1):11.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Filia A., Bella A., Del Manso M., et al. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 – what is making elimination so difficult? // Euro Surveill. 2017. Vol. 22, N 37. P. pii:30614.</mixed-citation><mixed-citation xml:lang="en">Filia A, Bella A, Del Manso M, et al. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 – what is making elimination so difficult? Euro Surveill. 2017;22(37):30614.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
