epidemiologyЭпидемиология и ВакцинопрофилактикаEpidemiology and Vaccinal Prevention2073-30462619-0494«Numicom» LLC10.31631/2073-3046-2019-18-4-14epidemiology-859Research ArticleПРОБЛЕМНАЯ СТАТЬЯPROBLEM-SOLVING ARTICLEРаспространенность генетической рекомбинации между вирусами и человеком, возможное ее влияние на вакцинациюThe Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on VaccinationХарченкоЕ. П.KharchenkoE. P.

Харченко Евгений Петрович, д. б. н., ведущий научный сотрудник 

194223, Санкт-Петербург, пр. Тореза, 44.

+7 (812) 552-70-31

Eugene P. Kharchenko, Dr. Sci. (Biol.), leader researcher

44 Toreza pr., St. Petersburg, Russian Federation, 194223

+7 (812) 552-70-31

neuro.children@mail.ruФГБУН «Институт эволюционной физиологии и биохимии им. И. М. Сеченова» РАНРоссияSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesRussian Federation201916012020186414Copyright © Харченко Е.П., 20202020Харченко Е.П.Kharchenko E.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epidemvac.ru/jour/article/view/859Актуальность

Актуальность. Рекомбинация геномов вирусов с геномом их хозяев хорошо известна, ее можно подразделить на реликтовую, реализованную в далеком эволюционном прошлом, и прижизненную, реализуемую в онтогенезе хозяина. Для хозяина рекомбинация может иметь различные последствия, природа которых не обнаруживается явно.

Цель исследования состояла в анализе (на основе компьютерного сравнения первичных структур белков) распространенности двунаправленной рекомбинации малыми фрагментами генома между вирусами и человеком и ее последствий.

Материалы и методы

Материалы и методы. Для компьютерного анализа были использованы доступные в Интернете базы данных первичных структур белков человека и вирусов.

Результаты

Результаты. Рекомбинация (скрытая и явная) малыми фрагментами генома между вирусами и человеком происходила многократно в прошлом, и в нее были вовлечены многие патогенные для человека вирусы.

Заключение

Заключение. Биоинформатика позволила «заглянуть» в прошлое вирусов и человека и выявить следы происходивших между ними обменов генетической информацией, которые могут предопределять эффекты разрабатываемых вакцин и диагностикумов.

Relevance

Relevance. The genetic recombination between viruses and men is known long ago. It can be divided on relict and ontogenic ones. For the host the recombination may display different consequences the nature of which is not exposed explicitly.

Aim is to analyze (on the base of computer comparison of the primary structure of viral and human proteins ) the occurrence of twodirectional recombination by small genome fragments between viruses and men and describe its possible after-effects.

Materials and methods

Materials and methods. For this computer study human and virus protein sequences were used from data bases available in INTERNET.

Results

Results. It was indicated that recombination (cryptical and explicit) by small genome fragments between viruses and men occurred many times in the past and many viruses pathogenic for men were involved in it.

Conclusion

Conclusion. The bioinformatics approach allows to look at the past of viruses and men and find the traces of genetic information changes between them that may predetermine the effects of vaccines and diagnostic immune tests.

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The authors declare that there are no conflicts of interest present.