Dispersal of Beijing B0/W148 M. tuberculosis Endemic Subclones in Territories of the Siberia and Far Eastern Federal District by Whole Genome Study
https://doi.org/10.31631/2073-3046-2020-19-3-41-45
Abstract
Relevance. The heterogeneity of the epidemic cluster B0/W148 in Russia is described for the first time. Aim of investigation was to create an epidemic model of tuberculosis strains B0/W148 spreading in Siberian Federal District (SFD) and Far Eastern Federal District (FEFD) and to identify the genetic relationship between the studied strains. Results and discussion. A comparative study of single nucleotide polymorphism (SNP) distribution in genomes of 20 strains from the SFD and FEFD and similar data in 62 strains from other regions of Russia was carried out. Based on Bayesian phylogenetic analysis was proposed epidemiological model of the emergence and spread of highly transmissible strains the B0/W148 cluster of M. tuberculosis in Russia. Siberian and Yakutian subclusters were identified and characterized by the simulation results.
About the Authors
P. A. Khromova
Scientific Center of Family Health and Human Reproduction Problems Abstract
Russian Federation
Russian Federation
Polina A. Khromova -Junior Research of Scientific Center of Family Health and Human Reproduction Problems.
Irkutsk.
+79041455222V. V. Sinkov
Scientific Center of Family Health and Human Reproduction Problems Abstract
Russian Federation
Russian Federation
Vyacheslav V. Sinkov - Cand. Sci. (Med.), Senior Research of Scientific Center of Family Health and Human Reproduction Problems.
Irkutsk.
+79025698481E. D. Savilov
Scientific Center of Family Health and Human Reproduction Problems Abstract
Russian Federation
Russian Federation
Evgeniy D. Savilov - Dr. Sci. (Med.), Professor, Chief Research Officer of Scientific Center of Family Health and Human Reproduction Problems.
Irkutsk.
+79148759919S. N. Zhdanova
Scientific Center of Family Health and Human Reproduction Problems Abstract
Russian Federation
Russian Federation
Svetlana N. Zhdanova - Dr. Sci. (Med.), Senior Research Officer of Scientific Center of Family Health and Human Reproduction Problems.
Irkutsk.
+79148774415O. B. Ogarkov
Scientific Center of Family Health and Human Reproduction Problems Abstract
Russian Federation
Russian Federation
Oleg B. Ogarkov - Dr. Sci. (Med.), Head of the Department of Epidemiology and Microbiology of Scientific Center of Family Health and Human Reproduction Problems.
Irkutsk.
+79642255258References
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Review
For citations:
Khromova P.A., Sinkov V.V., Savilov E.D., Zhdanova S.N., Ogarkov O.B. Dispersal of Beijing B0/W148 M. tuberculosis Endemic Subclones in Territories of the Siberia and Far Eastern Federal District by Whole Genome Study. Epidemiology and Vaccinal Prevention. 2020;19(3):41-45. (In Russ.) https://doi.org/10.31631/2073-3046-2020-19-3-41-45
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