Information support for monitoring post-vaccination immunity against plague

Relevance. The widespread use of information technologies, both when creating a database based on the results of immunological monitoring of persons vaccinated with the live plague vaccine, and for predicting the effectiveness of measures for specific prevention of plague in a specific territory, is aimed at ensuring epidemiological surveillance of plague in the territories of natural foci of infection. The aim of the work was to analyze the application of the created replenished database, which allows accumulating, archiving and systematizing the results of immunological monitoring of persons vaccinated against plague for informational support of sanitary and epidemiological surveillance of plague in the territories of natural foci of infection.

Materials and methods. The database included the results of a prospective cohort observational study. The database was created on the Microsoft Access 8.0 platform, an interactive software development environment for Visual Basic 6.0 with VB (Visual Basic) and / or SQL (structured query language) queries. To store the data, TXT files connected to the database were used.

Results. Permanent (region of residence, age, sex, blood group, genovariants of the human leukocyte antigen HLA) and variable (indicators of cellular and humoral immunity) parameters obtained as a result of long-term immunological monitoring of persons vaccinated with the live plague vaccine according to epidemic indications have been archived. Using the information support of the Database, an assessment of the state of anti-plague immunity was carried out and screening indicators of the immune status of the contingent at risk were determined, characterizing the individual response to vaccination.

Conclusions. The introduction of information technologies, which are the basis for multifactorial risk management of vaccine prevention, based on the use of modern databases for collecting, storing and analyzing data, makes it possible to make management decisions to optimize the volume and timing of measures for specific prevention of plague in the territories of natural foci of infection and in institutions that ensure the implementation of work with pathogens of especially dangerous infections.

1. Korzun V.M., Balakhonov S.V., Kosilko S.A., et al Features of the epizootic and epidemic activity of the Gorno-Altai natural plague focus in 2012-2016 [Text] // Epidemiology and vaccine prevention. - 2017. - No. 1 (92). - S. 36–38.

2. Popov N.V., Karnaukhov I.G., Pakskina N.D., et al. Assessment of the current epidemiological situation in the natural foci of the plague of the world. Increasing the efficiency of epidemiological surveillance in natural plague foci in the Russian Federation and forecasting their epizootic activity for 2019. Problems of especially dangerous infections. 2019; 1: 81–88. DOI: 10.21055/0370-1069-2019-1-81-88.

3. Bugorkova S.A., Shchukovskaya T.N., Mikshis N.I., et al Scientific and methodological support of measures for the immunological monitoring of persons vaccinated against plague living in the territories of natural foci of infection. Problems of especially dangerous infections. 2018; (2): 6–13. https://doi.org/10.21055/0370-1069-2018-2-6-13

4. Dyatlov I.I., Firstova V.V., Bondarenko N.L., et al A strategy for evaluating post-vaccination immunity against plague and tularemia. Allergology and Immunology. 2016 Volume 17 No. 2 p. 112–114

5. Firstova V. V., Kalmantaeva O. V., Gorbatov A.A., et al. Evaluation of specific humoral and cellular immunity in people periodically vaccinated against plague. Immunopa- thology, allergology, infectology. 2015, no. 3: 62–68. DOI: 10.14427/jipai.2015.3.62

6. Houe, H., Egenvall, A., Virtala, AM.. et al. Databases in veterinary medicine – validation, harmonisation and application: introduction. Acta Vet Scand 53, S1 (2011). https://doi.org/10.1186/1751-0147-53-S1-S1

7. Norton Yu.A., Andersen V. Design of Applications on the base of Original Version of Access 97 Software. Translated from the English. SPb.; 2000. 656 p.

8. Korneev V.V., Gareev A.F., Vasyutin S.V., Raikh V.V. Databases. Intelligent information processing. Knowledge. 2000. 352 p.

9. Visual Basic 6.0. Translated from the English. SPb.; 1998. 992 p.

10. Bugorkova S.A., Klyueva S.N., Kudryavtseva O. M., et al Immunological monitoring of vaccinated against plague in the Caspian sandy natural focus for the assessment and management of public health risks // Health risk analysis. - 2020. - No. 4. - P. 121–129. DOI: 10.21668/health.risk/2020.4.14

11. Kudryavtseva O.M., Goncharova A.Yu., Bugorkova S.A., et al Analysis factors influencing the immunological reactivity of persons vaccinated with a live plague vaccine print Public health and environment. 2020. No. 6 (327). S. 17–24. DOI: 10.35627/2219-5238/2020-327-6-17-24

12. Poland G.A., Ovsyannikova I.G., Kennedy R.B., et al. Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections. // OMICS. – 2011. – V. 15, № 9, Р. 625–636. DOI: 10.1089/omi.2011.0032

13. Sagiyev Z, Berdibekov A, Bolger T, et al. Human response to live plague vaccine EV, Almaty region, Kazakhstan, 2014-2015. PLoS ONE 14(6): e0218366. https://doi.org/10.1371/journal.pone.0218366