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Эпидемиология и Вакцинопрофилактика

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Вакцинопрофилактика у больных с хроническим лимфолейкозом

https://doi.org/10.31631/2073-3046-2021-20-3-91-106

Полный текст:

Аннотация

Актуальность. Инфекции являются наиболее частым осложнением хронического лимфолейкоза (ХЛЛ), согласно регистровым исследованиям, они становятся причиной смерти у 10–20% больных. Благодаря новым методам лечения ХЛЛ смертность, обусловленная прогрессией, снижается, тогда как летальность от инфекций в последние десятилетия остается постоянной.

Цель – анализ эффективности вакцинопрофилактики у пациентов с ХЛЛ по опубликованным данным, изучение предикторов неэффективности вакцинации, анализ текущих рекомендаций.

Заключение. Механизмы иммунной дисфункции при ХЛЛ различны и связаны как с собственно заболеванием, так и с проводимой терапией. Результаты многочисленных исследований свидетельствуют о том, что у пациентов с ХЛЛ имеется неадекватный ответ на большинство вакцин, применяемых по стандартным схемам в общей популяции. Вакцинация у пациентов с ХЛЛ остается слабо разработанной темой. Необходимо проведение дополнительных клинических исследований с целью повышения эффективности вакцинации больных ХЛЛ

Об авторах

М. И. Кислова
ФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской Федерации; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Россия

Мария Игоревна Кислова – cтудент; сотрудник лаборатории кариологии. 

Москва



А. А. Петренко
ГБУЗ Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

Андрей Анатольевич Петренко  – врач; аспирант 

Москва



М. П. Костинов
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет); ФГБНУ «НИИ вакцин и сывороток им. И. И. Мечникова»
Россия

Михаил Петрович Костинов  – д. м. н., профессор, заведующий лабораторией вакцинопрофилактики и иммунотерапии аллергических заболеваний, профессор кафедры эпидемиологии и  современных технологий вакцинации Института профессионального образования Сеченовского Университета. 

Москва



Е. А. Никитин
ГБУЗ Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

Евгений Александрович Никитин – д. м. н., профессор, заведующий дневным стационаром гематологии, онкологии и  химиотерапии городского гематологического центра ГКБ им. С. П. Боткина»; заведующий кафедрой гематологии и трансфузиологии 

125284, г.Москва, 2-й Боткинский пр-д, 5.



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Для цитирования:


Кислова М.И., Петренко А.А., Костинов М.П., Никитин Е.А. Вакцинопрофилактика у больных с хроническим лимфолейкозом. Эпидемиология и Вакцинопрофилактика. 2021;20(3):91-106. https://doi.org/10.31631/2073-3046-2021-20-3-91-106

For citation:


Kislova M.I., Petrenko A.A., Kostinov M.P., Nikitin E.A. Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems. Epidemiology and Vaccinal Prevention. 2021;20(3):91-106. (In Russ.) https://doi.org/10.31631/2073-3046-2021-20-3-91-106

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ISSN 2073-3046 (Print)
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