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Immunogenic Properties of Cell Wall Preparations of Francisella tularensis Different Subspecies in Experimental Tularemia

https://doi.org/10.31631/2073-3046-2018-17-2-46-49

Abstract

Immunogenic properties of cell wall (CW) preparations of Francisella tularensis four subspecies are investigated. It is shown that the  preparations from F. tularensis urea lysates are not toxic for  experimental animals. Besides, CW of F. tularensis А-61 subsp. mediasiatica and F. tularensis B-399 A-Cole subsp. tularensis  possess immunogenic activity in experimental tularemia caused by F. tularensis 306 subsp. holarctica.

About the Authors

A. V. Korneva
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


V. B. Nikolaev
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


T. A. Ivanova
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


V. I. Dubrovina
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


G. B. Mukhturgin
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


E. Yu. Markov
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


T. P. Starovoitova
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


A. V. Mazepa
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


T. T. Shkaruba
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


S. V. Balakhonov
Irkutsk Antiplague Research Institute of of Federal Service of Surveillance on Consumer' Rights Protection and Human Wellbeing
Russian Federation


References

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Review

For citations:


Korneva A.V., Nikolaev V.B., Ivanova T.A., Dubrovina V.I., Mukhturgin G.B., Markov E.Yu., Starovoitova T.P., Mazepa A.V., Shkaruba T.T., Balakhonov S.V. Immunogenic Properties of Cell Wall Preparations of Francisella tularensis Different Subspecies in Experimental Tularemia. Epidemiology and Vaccinal Prevention. 2018;17(2):46-49. (In Russ.) https://doi.org/10.31631/2073-3046-2018-17-2-46-49

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ISSN 2073-3046 (Print)
ISSN 2619-0494 (Online)