Аssessment of the Effectiveness of Etiotropic Prophylaxis of Tick-Borne Infections: the Systematization of concepts and methodological features
https://doi.org/10.31631/2073-3046-2018-17-48-56
Abstract
This review analyzes the methodological reasons for the heterogeneity of the results of the evaluation of the epidemiological effectiveness of vaccine prophylaxis of tick-borne encephalitis (TBE) using indicators such as the efficiency coefficient (COEF) and the efficiency index (IEF), and their discrepancy with similar indicators of the immunological effectiveness of vaccines. It is shown that the calculation of COEF and IEF according to official statistical reporting is illegal in connection with the emergence of systematic errors of selection due to the impossibility of retrospective formation of compared groups of vaccinated and unvaccinated, comparable in risk of infection and disease. In addition, COEF and IEF do not allow to compare the efficiency of vaccination in different areas in physical and monetary units. Based on the analysis of the literature data on immunogenicity of modern vaccines against TBE, protective titer of antibodies and results of field tests of vaccine efficacy in the conditions of total coverage of the population with vaccinations, the authors conclude that the third generation vaccines against TBE protect against disease 95-98% of persons attacked by ticks. Algorithm for calculating the number of preventable cases of TBE diseases is proposed for a comparative evaluation of the effectiveness of vaccination as an anti-epidemic measure in different areas.
About the Authors
N. A. Penyevskaya
Omsk Research Institute of Natural Focal Infections of Federal Service on Customers Rights Protection and Human Well-Being Surveillance; Omsk State Medical University of the Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Natalia A. Penjevskaya – Dr. Sci. (Med), head of department, chief research officer of the department of natural focal bacterial zoonoses of the Omsk Scientific Research Institute of Natural Focal Infections, professor of the department of epidemiology of the Omsk State Medical University.
644080, Omsk, Mira Avenue, 7; +7 3812 650572.N. V. Rudakov
Omsk Research Institute of Natural Focal Infections of Federal Service on Customers Rights Protection and Human Well-Being Surveillance; Omsk State Medical University of the Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Nikolai V. Rudakov – Dr. Sci. (Med), professor, director of the Omsk Scientific Research Institute of Natural Focal Infections, head of the department of Microbiology, Virology and Immunology, Omsk State Medical University.
644080, Omsk, Mira Avenue, 7; +7 3812 651633.References
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Review
For citations:
Penyevskaya N.A., Rudakov N.V. Аssessment of the Effectiveness of Etiotropic Prophylaxis of Tick-Borne Infections: the Systematization of concepts and methodological features. Epidemiology and Vaccinal Prevention. 2018;17(6):48-56. (In Russ.) https://doi.org/10.31631/2073-3046-2018-17-48-56
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