Post-Vaccination Immunity to Pertussis in Children of Lipetsk, New Management Capabilitiesto Infection
https://doi.org/10.31631/2073-3046-2019-18-3-60-64
Abstract
Relevance. In the structure of the incidence of controlled infections in the Russian Federation, whooping cough takes one of the leading places, and in 2018 there is a two-fold increase in the incidence compared with 2017.
The aim. Determination of the level of postvaccination immunity to pertussis infection in children of Lipetsk aged 3 to 10 years and assessment of the safety of booster vaccination with a combination vaccine against diphtheria and tetanus with acellular pertussis.
Materials and methods. Analysis of the incidence of pertussis and the quality of vaccine prevention according to planned seromonitoring in Lipetsk (2017). 100 patients were vaccinated with a booster dose of Adaсel. The study tested reactogenicity and safety of the vaccine.
Results. There is a relationship between the epidemic process of whooping cough and the short duration of post-vaccination immunity. Epidemiology of whooping cough dictates the need to change the tactics of vaccination, the introduction of repeated revaccination of children and adults using cell-free vaccines.
Conclusions The data obtained confirm the safety and good tolerability of the Adacel vaccine in clinical practice.
About the Authors
T. V. Timofeeva
State Healthcare Institution Lipetsk Regional Clinical Infectious Diseases Hospital
Russian Federation
Russian Federation
Tatyana V. Timofeeva - pediatrician of the highest category of Immunoprophylaxis Department.
Lipetsk, Gagarin Street, 137, 41. +7-910-742-34-78
E. G. Googe
State Healthcare Institution Lipetsk Regional Clinical Infectious Diseases Hospital
Russian Federation
Elvira G. Googe - pediatrician of Immunoprophylaxis Department
Russian Federation
Elvira G. Googe - pediatrician of Immunoprophylaxis Department
N. M. Fatina
Departament Rospotrebnadsora of Lipetsk Region
Russian Federation
Nina M. Fatina - expert-epidemiolog
Russian Federation
Nina M. Fatina - expert-epidemiolog
References
1. Infektsionnaya zabolevaemost' v Rossiyskoy Federatsii za yan var' - dekabr' 2018 g. A vailable at: https://rospotrebnadzor.ru/activities/statistical-materials/statictic_details.php?ELEMENT_ ID=11277Accessed: 20Mar2019. (In Russ.)
2. Pertussis vaccines: WHO position paper, August 2015. Weekly Epidemiological Recommendations. 2015;90(35):433-460.
3. Zaytsev EM, Mazurova IK, Petrova MS Sovershenstvovanie diagnostiki koklyushau vzroslykh s dlitel'nymkashlem. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 2009;2:70-75. (In Russ.)
4. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2017 godu: Gosudarstvennyy doklad. Moskva. Federal'naya sluzhba po nadzoru v sfere zashchitypravpotrebiteley i blagopoluchiya cheloveka;2018.268p. Available at: http://www.rospotrebnadzor.ru/upload/iblock/c51/gd_2017_seb.pdf Accessed: 20Mar2019. (In Russ.)
5. Tayts BM, Rakhmanova AG. Epidemicheskaya kharakteristika koklyusha vSankt-Peterburge. Vaktsinoprofilaktika. Kratkiyspravochnik;2001. P. 289-291. (In Russ.)
6. KostinovAM, KostinovMP Zabolevaemost'koklyushem i effect ot revaktsinatsii detey doshkol'nogo Ishkol'nogo vozrasta. Infektsiya i immunitet. 2018;3:284-294. (In Russ.)
7. BasovAA, Tsvirkun OV, Gerasimova AG. Rezul'taty izucheniya spetsificheskogo immuniteta k koklyushu u detey raznogo vozrasta. Evraziyskiy soyuz uchenykh. 2014;5:66-68. (In Russ.)
8. Mikheeva IV, Saltykova TS, Mikheeva MA. Tselesoobraznost'i perspektivy vaktsinoprofilaktiki koklyusha bez vozrastnykh ogranicheniy. Zhurnalinfektologii. 2018;4:14-23. (In Russ.)
9. Basov AA. Epidemicheskiy protsess koklyusha na sovremennom etape: avtoref. diss... kand. med.nauk. Moscow; 2016. Available at: http://www.crie.ru/pdf/disser1(basov).pdf Accessed: 20 Mar 2019. (In Russ.)
10. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya vAltayskom krae v2015 g. Gosudarstvennyy doklad. Upravlenie Rospotrebnadzora po Altayskomu krayu. Barnaul; 2016.256 p. (In Russ.)
11. Gorelikova, E.V. Optimizatsiya kliniko-laboratornoy diagnostiki i epidemiologicheskogo nadzora za koklyushem: avtoref. dis...kand. med. nauk. Perm'; 2006. A vailable at: https://search.rsl.ru/ru/record/01003293144 active on 10.04.2019 Accessed: 20 Mar 2019. (In Russ.)
12. Pis'mo Rospotrebnadzora RF N201/2412-16-31 ot29.02.2016 « O raz»yasnenii epidemiologicheskoy tselesoobraznosti revaktsinatsii protivkoklyusha». (In Russ.)
13. LP 003707-280616, 2019. Adasel' (Vaktsina dlya profilaktiki difterii (s umen'shennym soderzhaniem antigena), stolbnyaka I koklyusha (beskletochnaya), kombinirovannaya, adsorbirovannaya). (In Russ.)
14. Hellebrand W. The epidemiology of pertussis in Germany: past and present. BMC Infectious Diseases. 2009:9-22. Doi:10.1186/1471-2334-9-22
15. Dalby T, Hoffmann P. Epidemiology of pertussis in Denmark, 1995 to 2013. EuroSurveillance. 2016;21(36):30334. Doi: 10.2807/1560-7917.ES.2016.21.36.30334
16. De Greeff SC, Mooi FR, Schellekens JF. Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in the Netherlands. Pediatric Infectious Disease Journal. 2008;27(3):218-23.
17. Wiley KE, .Zuo Y, Macartney KK. Sources of pertussis infection in young infants: a review of key evidence informing targeting of the cocoon strategy. Vaccine. 2013;31:618-625.
18. Babachenko IV. Koklyush u detey. Saint Petersburg: Kommentariy; 2014. P. 157-158. (In Russ.)
19. Popova OP. Koklyush u detey: kliniko-immunologicheskie aspekty, diagnostika i lechenie. Dissertatsiya na soiskanie uchenoy stepeni dokt. Moscow; 2014. P. 9-10. (In Russ.)
Review
For citations:
Timofeeva T.V., Googe E.G., Fatina N.M. Post-Vaccination Immunity to Pertussis in Children of Lipetsk, New Management Capabilitiesto Infection. Epidemiology and Vaccinal Prevention. 2019;18(3):60-64. (In Russ.) https://doi.org/10.31631/2073-3046-2019-18-3-60-64
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