Influenza Vaccine Effectiveness Assessed at Different Stages of the Epidemic Cycle in Reducing the Frequency of Hospitalization with Influenza
D. M. Danilenko,
A. A. Sominina,
A. B. Komissarov,
M. M. Pisareva,
D. A. Guzhov,
E. A. Dondurey,
E. V. Obraztsova,
E. G. Rozhkova,
V. F. Sukhovetskaya,
V. S. Timonina,
K. A. Stolyarov,
D. V. Petrov,
E. A. Smorodintseva,
M. I. Bakaev,
T. P. Levanyuk,
O. I. Afanasyeva,
D. A. Lioznov,
A. V. Vasin,
A. A. Yakovlev https://doi.org/10.31631/2073-3046-2019-18-5-63-69
Abstract
Relevance. Influenza vaccination is considered as the most effective way to prevent this infection. In the past epidemic season in Russia, the main share of influenza vaccines comprised domestically produced vaccines. Aims was to assess the vaccine effectiveness (VE) in preventing severe forms of influenza that require hospitalization. Materials & Methods. To collect clinical and epidemiologicaldata for the epidemic season 2018–2019. an active prospective surveillance approach was used. The study included 6 departments of three infectious diseases hospitals in St. Petersburg. Results It was established that early VE, estimated during the epidemic, was 66.4% for children and 64.7% for adults. Evaluation of VE for the entire study period from week 52 of 2018 to week 13 of 2019, showed that it decreased, the total VE for this period was 48.4%. Conclusions The data obtained in the course of the study indicate a pronounced protective role of vaccination in preventing the development of severe forms of influenza with subsequent hospitalization.
Keywords
influenza,
vaccine,
virus,
efficacy,
hospitalization,
diagnosis,
epidemic,
polymerase chain reaction
About the Authors
D. M. Danilenko
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
Daria M. Danilenko – Cand. Sci. (Biol.), Deputy Director for Science of Smorodintsev Research Influenza Institute.
prof. Popov street, 15/17, Saint-Petersburg, 197376.
+7-921-996-20-34.
A. A. Sominina
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
A. B. Komissarov
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
M. M. Pisareva
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
D. A. Guzhov
Clinical Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Russian Federation
Dmitry A. Guzhov – doctor of Clinical Infectious Diseases Hospital named after S. P. Botkin.
+7-921-978-74-71.
E. A. Dondurey
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
E. V. Obraztsova
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
E. G. Rozhkova
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
V. F. Sukhovetskaya
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Vera F. Sukhovetskaya – assistant of the department of St. Petersburg State Pediatric Medical University.
+7-981-149-07-97.
V. S. Timonina
Children's City Hospital of St. Olga
Russian Federation
Russian Federation
Veronika S. Timonina, – doctor of Children’s City Hospital of St. Olga.
+7-921-575-39-97.
K. A. Stolyarov
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
D. V. Petrov
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
E. A. Smorodintseva
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
M. I. Bakaev
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
T. P. Levanyuk
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
O. I. Afanasyeva
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
D. A. Lioznov
Smorodintsev Research Influenza Institute; First St. Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
Dmitry A. Lioznov – Dr. Sci. (Med.), Deputy Director on Scientific of Smorodintsev Research Institute of Influenza, Head of the Department of Infectious Diseases and Epidemiology of First St. Petersburg Pavlov State Medical University.
+7 (812) 499-15-38.
A. V. Vasin
Smorodintsev Research Influenza Institute
Russian Federation
Russian Federation
prof. Popov street, 15/17, Saint-Petersburg, 197376.
A. A. Yakovlev
St. Petersburg State Pediatric Medical University; Children's City Hospital of St. Olga
Russian Federation
St. Petersburg.
Russian Federation
St. Petersburg.
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For citations:
Danilenko D.M., Sominina A.A., Komissarov A.B., Pisareva M.M., Guzhov D.A., Dondurey E.A., Obraztsova E.V., Rozhkova E.G., Sukhovetskaya V.F., Timonina V.S., Stolyarov K.A., Petrov D.V., Smorodintseva E.A., Bakaev M.I., Levanyuk T.P., Afanasyeva O.I., Lioznov D.A., Vasin A.V., Yakovlev A.A. Influenza Vaccine Effectiveness Assessed at Different Stages of the Epidemic Cycle in Reducing the Frequency of Hospitalization with Influenza. Epidemiology and Vaccinal Prevention. 2019;18(5):63-69. (In Russ.) https://doi.org/10.31631/2073-3046-2019-18-5-63-69
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