Вакцины для профилактики хантавирусных лихорадок
https://doi.org/10.31631/2073-3046-2019-18-5-98-108
Аннотация
Хантавирусы являются высоко патогенными для человека возбудителями хантавирусных лихорадок, включая геморрагическую лихорадку с почечным синдромом, регистрируемую среди людей в странах евразийского континента и заболевание под названием «хантавирусный пульмональный синдром» – в странах Северной и Южной Америк. Совсем недавно распространение хантавирусных заболеваний было обнаружено и в Африке. До сих пор не существует лекарственных препаратов для специфической противовирусной терапии. Наиболее перспективным методом борьбы с хантавирусными лихорадками является специфическая профилактика, то есть вакцинация населения против хантавирусов, обусловливающих эндемичность разных территорий. В этом обзоре обобщены современные данные о существующих и разрабатываемых вакцинах против хантавирусных лихорадок.
Об авторах
А. А. СинюгинаРоссия
Синюгина Александра Александровна – научный сотрудник, руководитель производственного направления.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва, 108819.
+7 (495)841-0173.
А. А. Ишмухаметов
Россия
Ишмухаметов Айдар Айратович – генеральный директор.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 8(495)841-9002.
Т. К. Дзагурова
Россия
Дзагурова Тамара Казбековна – заведующая лабораторией.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495)841-094.
М. В. Баловнева
Россия
Баловнева Мария Владимировна – ведущий научный сотрудник.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495)841-094.
М. С. Егорова
Россия
Егорова Мария Сергеевна – старший научный сотрудник.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495)841-094.
С. С. Курашова
Россия
Курашова Светлана Сергеевна – младший научный сотрудник.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495)841-094.
Н. А. Коротина
Россия
Коротина Наталья Александровна – научный сотрудник.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495)841-094.
О. А. Леонович
Россия
Леонович Оксана Александровна – старший научный сотрудник.
посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495)841-094.
А. С. Балкина
Россия
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
Е. А. Ткаченко
Россия
Ткаченко Евгений Александрович – руководитель научного направления.
поселение Московский, посёлок Института полиомиелита, домовладение 8, корпус 1, Москва,108819.
+7 (495) 841-9035.
Список литературы
1. Oya A. Japanese encephalitis vaccine: the vaccination. International Medical Foundation of Japan 1976; 69–72.
2. Lee H.W., Ahn C.N. Development of a vaccine against hemorrhagic fever with renal syndrome. J. Korean Soc Virol. 1988. 18:143–148.
3. Lee H.W., Ahn C.N., Song J.W., et al. Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. Arch Virol. 1990. 1(Suppl 1): 35–47
4. Yamanishi K, Tanishita O, Tamura M et al. Development of inactivated vaccine against virus causing hemorrhagic fever with renal syndrome. Vaccine. 1988. 6: 278–282.
5. Ким Р., Ру Ч., Ким Г.М. с соавт. Специфическая профилактика ГЛПС в КНДР. Тезисы международного симпозиума по ГЛПС. Ленинград, СССР, 1991, C. 16–17
6. Kim R, Ryu C, Kim G et al. Antibody formation and epidemiological preventive effect after vaccination with the inactivated vaccine against HFRS. In: Abstract of 2nd symposium on arboviruses in the Mediterranean countries, Dubrovnik, 1989. p 58.
7. Kim R.J., Ru C, Kim G.M. The special prevention of HFRS in P.D.R of Korea. Chin Clin Exp Virol. 1991. 4: 487–492.
8. Sun Z, Yu Y, Wang W, Wang D. Studies on the purified inactivated epidemic hemorrhagic fever vaccine. Clinical trial of type 1 EHF vaccine in volunteers. In: Abstract of 2nd international conference on HFRS, Beijing, 1992. pp 109–110.
9. Yu Y.X., Dong G.M., Yao X.J. et al. Comparative studies on the immunogenicity of different types of HFRS inactivated. Virol Sin. 1990. 1: 63–66.
10. Astakhova T., Slonova R., Minskaya L. et al. The elaboration of inactivated vaccine against HFRS. In: Abstract of 3rd international conference on HFRS and hantaviruses, Helsinki, 1995. p. 62.
11. Yu Y.X, Yao X.J, Dong G.M. et al. Antibody response of inactivated HFRS vaccine to homologous and heterologous types of the virus. Chin J Biol. 1990. 3: 14–16.
12. Cho H.W., Howard CR. Antibody response in humans to an inactivated hantavirus vaccine (Hantavax). Vaccine. 1999 17: 2569–2575.
13. Cho H.W., Howard C.R., Lee H.W. Review of an inactivated vaccine against hantaviruses. Intervirology. 2002. 45: 328–333.
14. Sohn Y.M., Rho H.O., Park M.S. et al. Primary humoral immuno responses to formalin inactivated hemorrhagic fever with renal syndrome vaccine (Hantavax): consideration of active immunization in South Korea. Yonsei Med J. 2001. 42: 278–284.
15. Lee H.W., Chu Y.K., Woo Y.D. et al. Vaccine against haemorrhagic fever with renal syndrome. In: Saluzzo JF, Dodet В (eds) Factors in the emergence and control of rodent-borne diseases. Elsevier, Paris, 1999: 267–272.
16. Bozovic B, Lee H.W., Samardzic S. et al. Follow-up of immune response of the vaccines by Hantavax vaccine in endemic foci of hemorrhagic fever with renal syndrome in Yugoslavia. In: Abstract of 5th international conference on HFRS, HPS, and hantaviruses, Veyrier-du-Lac, France, 2001, p 235.
17. de Carvalho N.C, Gonzalez Delia Valle M. et al. A Cross-protection against challenge with Puumala virus after immunization with nucleocapsid proteins from different hantaviruses. Virology. 2002. 76 (13): 6669–6677.
18. Dargeviciute A, Brus S.K., Sasnauskas K. et al. Yeast-expressed Puumala hantavirus nucleocapsid protein induces protection in a bank vole model. Vaccine. 2002. 20 (29–30): 3523–3531.
19. Lee H.W., Chu Y.K., Cui Y.S. et al. Immune reaction of the vaccinated hamster with combination Hantaan-puumala vaccine. J Korean Soc Virol. 1997. 27: 39–47
20. Hwang Y.H., Kang M.S., Lim K.O., Lee S.M. Toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. Yonsei Med. J. 2012. 53 (1): 228–230.
21. Song G, Huang Y et al. Human trial of a bivalent inactivated GHKC vaccine against HFRS. In: Abstract of 2nd international conference on HFRS, Beijing, 1992. p. 103.
22. Dong G., An Q., Zhihue Y., Wenxue L. Efficacy of a chicken embryo tissue culture inactivated HFRS vaccine used in a clinical trial. In: Abstract of 5th international conference on HFRS, HPS and hantaviruses 2001, France, p. 239.
23. Choi Y., Ahn C.J., Seong K.M. et al. Inactivated Hantaan virus vaccine derived from suspension culture of Vero cells. Vaccine. 2003. 21: 1867–1873.
24. Li D, Dong G. Vaccines against hantaviruses in China. In: Abstract of 5th international conference on HFRS, HPS, and hantaviruses, Veyrier-du-Lac, France, 2001. p. 121.
25. Zhao T.G., Ying S et al. Effective appraisement of inactivated vaccine against HFRS prepared from Meriones unguiculatus and Alaetagulus pumillio kerr kidney culture. In: Abstract of 4th international conference on HFRS and hantaviruses, Atlanta, 1998. p. 104.
26. Song G, Huang YC, Hang CS. Preliminary human trial of inactivated golden hamster kidney cell vaccine against HFRS. Vaccine. 1992. 10: 214–216.
27. Liu W.M., Song G, Zhang Q.F. Comparative studies on inactivating methods for production of inactivated cell culture vaccine against epidemic hemorrhagic fever. Chin J Virol. 1992. 3: 141–146.
28. Hang C.S., Xie Y.X., Wang S.W. Advances on development of purified bivalent vaccine against HFRS prepared on Vero cells. In: Abstract of 6th international conference on HFRS, HPS and hantaviruses, Seoul, 2004. p. 152.
29. Ткаченко Е.А., Дзагурова Т.К., Набатников П.А., Малкин А.Е., Коротина Н.А. и др. Разработка экспериментальной вакцины против геморрагической лихорадки с почечным синдромом. Медицинская вирусология. 2009. 26: 194–196.
30. Ткаченко Е.А., Ишмухаметов А.А., Дзагурова Т.К. и др. Разработка экспериментально-промышленной технологии производства вакцины для профилактики геморрагической лихорадки с почечным синдромом. Ремедиум. 2015. 6: 47–53.
31. Hao F.Y., Hui L.G., Zhao X.L. Efficacy test for inactivated epidemic hemorrhage fever vaccine using golden hamsters. Chin. J. Biol. 1996. 9: 69–72.
32. Ren K., Lu Q.X., Song G. Serological efficacy of the inactivated golden hamster kidney cell vaccine against hemorrhagic fever with renal syndrome in human trial. Chin J Exp Clin Virol. 1996. 10: 10–15.
33. Zhu Z.Y., Zeng R.F., Yu X.Y. Efficacy of inactivated EHF vaccine in clinical trial. Virol Sin. 1991. 6: 315–319.
34. Yu Y.X., Liu W.X., Nei Z.L. Neutralizing antibody response in humans immunized with Meriones gerbil kidney tissue culture inactivated HFRS vaccine assessed by two methods. Virol. Sin. 1992. 7: 176–180.
35. Chen H.X., Wang N., Zhang Y. Evaluation of the efficacy of vaccines against HFRS and study on their antibody dependent immunization enhancement and immunological strategy. In: Abstract of 4th international conference on HFRS and hantaviruses, Atlanta, 1998. p. 87.
36. Li D. Trends of HFRS epidemiology and the expanded program on immunization with hantavirus vaccines in China. In: Abstract of 8th international conference on HFRS HPS and hantavirus, Athens, 2010. p. 82.
37. Zhang Y.Z, Zou Y., Fu Z.F, Plyusnin A. Hantavirus infections in humans and animals, China. Emerg Infect Dis. 2010. 16 (8):1195–1203.
38. Schmaljohn C.S. Vaccines for hantaviruses: progress and issues. Expert Rev Vaccines. 2012. 11 (5): 511–513.
39. Chu Y.K., Jennings G.B., Schmaljohn C.S. (1995) A vaccinia virus-vectored Hantaan virus vaccine protects hamsters from challenge with Hantaan and Seoul viruses but not Puumala virus. J. Virol. 69 (10): 6417–6423.
40. Schmaljohn C. Vaccines for hantaviruses. Vaccine. 2009. 27: 61–64.
41. Дзагурова Т.К., Ткаченко Е.А., Башкирцев В.Н., и др. Выделение и идентификация штаммов хантавирусов-возбудителей ГЛПС в европейской части России. Медицинская вирусология. 2008. 25: 142–150.
42. Klempa B, Tkachenko EA, Dzagurova TK et al. Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerg Infect Dis. 2008. 14: 617–625.
43. Дзагурова Т.К., Морозов В.Г., Юничева Ю.В. и др. Этиологическая роль генотипов вируса Добрава в структуре заболеваемости ГЛПС. Медицинская вирусология. 2009. 26: 165–167.
44. Дзагурова Т.К., Солопова О.Н., Свешников П.Г., Коротина Н.А. и др. Разработка иммуноферментной тест-системы на основе моноклональных антител для определения специфической активности вакцины против геморрагической лихорадки с почечным синдромом. Вопр. вирусол. 2013. 1: 40–44.
45. Бархалёва О.А., Воробьёва М.С., Ладыженская И.П., Ткаченко Е.А., Дзагурова Т.К. Вакцина против геморрагической лихорадки с почечным синдромом. Биопрепараты. 2011. 1: 27–30.
46. Schmaljohn C., Hasty S., Dalrymple J. Preparation of candidate vaccinia-vectored vaccines for HFRS. Vaccine, 1992; 10: 10–13.
47. Kamrud K., Nelle T., VanderZanden L. et al. Evaluation of naked DNA and alphavirus-based hantavirus vaccines. Abstracts of 4th Intern. Confer. on HFRS and Hantaviruses. Atlanta, USA, 1998, P. 95.
48. Hooper J., Kamrud K., Elgh F. et al. Development and testing of DNA vaccines against hantaviruses. Am. J. of Trop. Med. and Hyg. 1998; 59 (Supplement 3): 124–125.
49. Bharadwaj M., Lyons C., Wortman B., Hjelle B. Genetic immunization with Sin Nombre virus cDNAs induces T cell proliferative responses and antibodies in Balb/C mice. Am J of Trop. Med. and Hyg.. 1998; 59 (Supplement 3), P. 124.
50. Yoshimatsu K., Yoo Y.C., Yoshida R. Protective immunity of Hantaan virus nucleocapsid and envelope protein studied using baculovirus-expressed proteins. Arch. Virol. 1993; 130 (3–4): 365–376.
51. Schmaljohn C.S., Chu Y.K., Schmaljohn A.L., Dalrymple J.M. Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants. Virology. 1990. 64 (7): 3162–3170.
52. McClain D.J., Summers P.L., Harrison S.A. et al. Clinical evaluation of a vaccinia-vectored Hantaan virus vaccine. J. Med. Virol. 2000; 60: 77–85.
53. Hammerbeck C.D., Wahl-Jensen V, Hooper J.W. Hantavirus. In: Barrett ADT, Stanberry L.R. (eds) Vaccines for biodefense and emerging and neglected diseases. Academic Press/Elsevier, London, 2009: 379–412.
54. Safronetz D, Hegde N.R., Ebihara H. et al. Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with Andes virus. J Virol. 2009. 83: 7285–7295.
55. Yuan Z.G., Li X.M., Mahmmod Y.S., Wang X.H. A single immunization with a recombinant canine adenovirus type 2 expressing the seoul virus Gn glycoprotein confers protective immunity against seoul virus in mice. Vaccine. 2009; 27: 5247–5251.
56. Yuan Z.G., Luo S.J., Xu H.J. Generation of E3-deleted canine adenovirus type 2 expressing the Gc glycoprotein of Seoul virus by gene insertion or deletion of related terminal region sequences. J. Gen. Virol. 2010; 91: 1764–1771
57. Giese M. DNA-antiviral Vaccines: New developments and Approaches – a review. Virus Genes 1998; 17 (3): 219–32.
58. Lai W.C., Bennett M. DNA vaccines. Crit. Rev.Immunol 1998; 18 (5): 449–84.
59. Hooper J., Kamrud K., Elgh F., Custer D., Schmaljohn C. DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects Seoul virus infection. Virology. 1999; 255: 269–278.
60. Kamrud K., Hooper J., Elgh F., Schmaljohn C. Comparison of the protective efficacy of naked DNA, DNA-based Sindbis replicon, and packaged Sindbis replicon vectors expressing hantavirus structural genes in hamsters. Virology, 1999; 263: 209–219.
61. Boudreau E., Sellers K., Rusnak J. et al. Phase 1 clinical study on the safety, tolerability and immunogenicity of Hantaan and Puumala DNA vaccines. In: Abstracts of the 8th international conference on HFRS HPS and hantavirus, Athens, 2010. p. 83.
62. Filatov F, Tkachenko E, Schmaljohn C, Hooper J et al. Immune response to aerosol delivery of the cloned hantavirus genes. In: Abstracts of 7th international conference on HFRS, HPS and hantaviruses, Buenos Aires, 2007. p. 187.
63. Boudreau E.F., Josleyn M., Ullman D. A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome. Vaccine. 2012; 30: 1951–1958.
64. Zhao C., Zhao Y.S, Wang S. Immunogenicity of a multiepitope DNA vaccine against hantavirus. Hum Vaccines Immunother. 2012; 8 (2): 208–215.
65. Schmaljohn C.S, Spik K.W, Hooper J.W. DNA vaccines for HFRS: laboratory and clinical studies. Virus Res. 2014. 187: 91-6.
66. Kwilas S., Kishimori J.M., Josleyn M. et al. A Hantavirus Pulmonary Syndrome (HPS) DNA Vaccine Delivered Using a Spring-powered Jet Injector Elicits a Potent Neutralizing Antibody Response in Rabbits and Nonhuman Primates. Current Gene Therapy. 2014; 14: 200–210.
67. McCoy J.R., Mendoza J.M., Spik K.W. et al. Schmaljohn C.S., Sardesai N.Y., Broderick K.E. A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin. Hum Vaccin Immunother. 2015; 11 (3): 746–54.
68. Hooper J.W., Moon J.E., Paolino K.M. et al. Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation. Clin Microbiol Infect. 2014; 20 (5): 110–117.
69. Cichutek K. DNA vaccines: development, standardization and regulation. Intervirology. 2000; 43: 331–8.
70. Haese N., Brocato R.L., Henderson T. et al. Antiviral Biologic Produced in DNA Vaccine/ Goose Platform Protects Hamsters Against Hantavirus Pulmonary Syndrome When Administered Post-exposure. PLOS Neglected Trop Dis. 2015; 1: 19.
71. Hooper J.W., Brocato R.L., Kwilas S. A. et al. DNA vaccine–derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome. Sci Transl Med. 2014. 26; 6 (264): 264–70.
72. Kobak L., Raftery M.J., Voigt S. et al. Hantavirus-1 induced pathogenesis in mice with a humanized immune system. J. Gen. Virol. 2015. 96: 1258–63.
73. Hjelle B. Vaccines against hantaviruses. Expert Rev Vaccines. 2002. 1: 373–384.
Рецензия
Для цитирования:
Синюгина А.А., Ишмухаметов А.А., Дзагурова Т.К., Баловнева М.В., Егорова М.С., Курашова С.С., Коротина Н.А., Леонович О.А., Балкина А.С., Ткаченко Е.А. Вакцины для профилактики хантавирусных лихорадок. Эпидемиология и Вакцинопрофилактика. 2019;18(5):98-108. https://doi.org/10.31631/2073-3046-2019-18-5-98-108
For citation:
Sinyugina A.A., Ishmukhametov A.A., Dzagurova Т.К., Balovneva М.V., Egorova М.S., Kurashova S.S., Korotina N.A., Leonovich O.A., Balkina A.S., Tkachenko Е.A. Vaccines for Prevention of Hantaviral Fevers. Epidemiology and Vaccinal Prevention. 2019;18(5):98-108. (In Russ.) https://doi.org/10.31631/2073-3046-2019-18-5-98-108