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Эпидемиология и Вакцинопрофилактика

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На путях к индивидуализации вакцинации: значение возраста и пола

https://doi.org/10.31631/2073-3046-2021-20-6-88-99

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Аннотация

Актуальность. Высокая вариабельность защиты от инфекций, контролируемых вакцинацией, включая COVID-19, является одной из актуальных проблем инфектологии. Цель. На основе анализа результатов научных публикаций и отчетов проанализирована роль факторов возраста и пола, их взаимодействия и основных механизмов в иммунном ответе на вакцины, в совершенствовании вакцин и схем вакцинации. Заключение. Показано, что вакцинопрофилактика всегда развивалась в направлении индивидуализации, проходя этапы определения целевых групп и разработки схем иммунизации различных групп. Проанализированы полученные в последние десятилетия важные данные о значении генетических и внешних факторов, в частности, возраста и пола, в вариабельности ответа на вакцины. Анализ роли таких факторов выполнен также для коронавирусных вакцин. Обсуждены необходимость и возможности очередных действий, которые могут обеспечить оптимальные ответы различных людей на вакцинацию.

Об авторе

Б. В. Каральник
Общественное Объединение «Научно-медицинское общество»; Научный центр гигиены и эпидемиологии им. Х. Жуматова, филиал Национального Центра общественного здравоохранения
Казахстан

Борис Вольфович Каральник  – д. м. н. (микробиология), профессор (иммунология), главный научный сотрудник, Общественное Объединение «Научно-медицинское общество»

Республика Казахстан
Тел. +7 27 303 10 89, +7 (705) 302-86-78



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Каральник Б.В. На путях к индивидуализации вакцинации: значение возраста и пола. Эпидемиология и Вакцинопрофилактика. 2021;20(6):88-99. https://doi.org/10.31631/2073-3046-2021-20-6-88-99

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Karalnik B.V. On the Road to Individualization of Vaccination: the Significance of Age and Sex. Epidemiology and Vaccinal Prevention. 2021;20(6):88-99. (In Russ.) https://doi.org/10.31631/2073-3046-2021-20-6-88-99

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