The Susceptibility of Meningococci to the Antimicrobial Agents in Moscow 2006 - 2015
https://doi.org/10.31631/2073-3046-2016-15-3-7-14
Abstract
Relevance. One of the prognostic criteria meningococcal infection (MI) epidemic status process is the increasing number of resistant to antibiotics meningococcal strains. Aim of this study was to investigate the dynamics of invasive strains of N. meningitidis susceptibility to antibiotics in Moscow in 2006 - 2015. Materials and methods. Studied 98 strains of N. meningitidis, isolated from blood and cerebrospinal fluid of patients with MI. The study changes of sensitivity N. meningitidis to antibiotics was occured in two periods: first -2006 - 2011 and second - 2012 - 2015. The MIC was determined by E-test. Results. In the present study revealed for the first time the Russian strains of N. meningitidis, moderately resistant to penicillin (5 strains) and resistant to rifampicin (3 strains). Among the studied strains were not found resistant to ceftriaxone, ciprofloxacin, tetracycline and chloramphenicol. Discussion. Comparison results two study periods allowed to reveal the dynamics of increasing the sensitivity of N. meningitidis to antibiotics, which confirms the decline in meningococcal virulence, and as a result, continued interepidemic MI period. Conclusions. Despite the decline antibakterial resistance is required continuous monitoring.
About the Authors
M. A. Koroleva
Federal Budget Institution of Science «Central Research Institute of Epidemiology» of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance
Russian Federation
Russian Federation
I. S. Koroleva
Federal Budget Institution of Science «Central Research Institute of Epidemiology» of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance
Russian Federation
Russian Federation
I. M. Zakroeva
Federal Budget Institution of Science «Central Research Institute of Epidemiology» of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance
Russian Federation
Russian Federation
I. M. Gruber
Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
References
1. Koroleva I.S., Beloshitsky G.V., Zakroeva I.M., Koroleva M.A. Meningococcal disease in the Russian Federation. Medical alphabet. Epidemiology and hygiene. 2015; 1: 27 – 28 (in Russian).
2. Vazquez J.A. The resistance of Neisseria meningitidis to the antimicrobial agents: an issue still in evolution. Rev. Med. Microbiol. 2001; 12: 39 – 45.
3. Richter S.S., Gordon K.A., Rhomberg P.R., Pfaller M.A., Jones R.N. Neisseria meningitidis with decreased susceptibility to penicillin: report from the SENTRY antimicrobial surveillance program, North America, 1989 – 99. Diagn. Microbiol. Infect. Dis. 2001; 41: 83 – 88.
4. Shultz T.R., Tapsall J.W., White P.A., Newton P.J. An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones. Antimicrob. Agents Chemother. 2000; 44: 1116.
5. Tapsall J.W., Shultz T., Limnios E., Munro R., Mercer J., Porritt R. et al. Surveillance of antibiotic resistance in invasive isolates of Neisseria meningitidis in Australia 1994 – 1999. Pathology. 2001; 33: 359 – 361.
6. Backman A., Orverlid P., Vazquez J.A., Skold O., Olcen P. Complete sequence of a beta-lactamase encoding plasmid in Neisseria meningitidis. Antimicrob. Agents Chemother. 2000; 44: 210 – 212.
7. Cuevas L.E., Hart C.A. Chemoprophylaxis of bacterial meningitis. J. Antimicrob. Chemother. 1993; 31 (Suppl. B): 79 – 91.
8. Vazquez J.A., Arreaza L., Block C., Ehhard I. Interlaboratory comparison of agar dilution and etest metods for determining the MICs of antibiotics used in management of Neisseria meningitidis infections. Antimicrob. Agents Chemother. 2003; 47: 3430 – 3434.
9. Vazquez J.A., Enriquez R., Abad R., Alcala B. et al. Antibiotic resistant meningococci in Europe: Any need to act? FEMS Microbiol Rev. 2007; 31: 64 – 70.
10. Saez-Nieto J.A., Lujan R., Berron S., Campos J., Viñas M., Fusté C. et al. Epidemiology and molecular basis of penicillin resistant Neisseria meningitidis in Spain. A five year history (1985 – 1989). Clin. Infect. Dis. 1992; 14: 394 – 402.
11. Corso A., Faccone D., Miranda M., Rodriguez M.et al. Emergence of Neisseria meningitidis with decreased susceptibility to ciprofloxacin in Argentina. Antimicrob. Chemother. 2005; 55: 596 – 597.
12. Koroleva I.S. Microbiological monitoring of the system of epidemiological surveillance of purulent bacterial meningitis: PhD of med. sci. diss. Moscow. 2000 (in Russian).
13. Kukhtevich E.V. Features of epidemic process of meningococcal disease at the stage of reducing morbidity: PhD of med. sci. diss. Moscow. 1992 (in Russian).
Review
For citations:
Koroleva M.A., Koroleva I.S., Zakroeva I.M., Gruber I.M. The Susceptibility of Meningococci to the Antimicrobial Agents in Moscow 2006 - 2015. Epidemiology and Vaccinal Prevention. 2016;15(3):7-14. (In Russ.) https://doi.org/10.31631/2073-3046-2016-15-3-7-14
Views:
1041
Email this article 