Actual Aspects of Epidemiological Well-Being Support Anti-PLAgue for Population in Altai Republic

Relevance. Despite significant advances in modern medicine in the treatment of infectious diseases, the plague has not lost its relevance and is one of the socially significant epidemic threats as a particularly dangerous infection. Every year, there are nearly 2.5 thousand cases of plague in the world, and the mortality rate 7 - 13%. Goal. Analysis of the current epizootic and epidemiological situation of the plague, and to determine the optimal set of preventive measures to ensure epidemiological welfare of population of the Republic of Altai on this particularly dangerous infectious disease. Materials and methods. Used the results of monitoring in 1961 - 2015 years of Gorno-Altai natural foci of plague. For more than 50 years bacteriologically were examined more than 290 thousand. small mammals, more than 1545 thousand fleas, isolated 2435 strains of the plague pathogen. Results. In recent years, the Gorno-Altai foci of plague most active of the 11 natural focis, located in Russia. On the Gorno-Altai territory in 2001 to 2014 isolated 801 strain of the pathogen, in 2015 - 23 strains, including 17 main subspecies. currently in the Gorno-Altai natural foci of plague there is a joint circulation of the two subspecies of the plague microbe: Y. pestis subsp. altaica and Y. pestis subsp. pestis. In September 2014 the first time since the detection foci of plague (1961) recorded the local human case of bubonic plague. in August 2015 identified a new case of the plague Conclusions. Introduction of the plague pathogen main subspecies into the ecosystem of the Gorno-Altaisk natural foci of plague greatly increases the possibility of dangerous epidemiological situation

чума, заболевание людей, интродукция возбудителя чумы основного подвида, Горный Алтай, природный очаг, эпизоотическая ситуация, профилактические и противоэпидемические мероприятия, plague, human case, introduction of Yersinia pestis basic subspecies, Mountain Altai, a natural focus, epizootic situation, preventive and anti-epidemic actions

1. Plague Manual: Epidemiology, Distribution, Surveillance and Control. WHO, Geneva; 1999. Available at: http://www.who.int/emc.

2. Kokushkin A.M. Social and biological aspects of plague epidemiology: PhD of med. sci. diss. Saratov; 1995 (in Russian).

3. Popov N.V., Bezsmertnyi V.E., Matrosov A.N., Knyazeva T.V., Kuznetsov A.A., Fedorov M.Yu. et al. Epizootic activity of natural plague foci in the territory of the Russian Federation in 2014 and prognosis for 2015. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2015; 1: 10 – 17 (in Russian).

4. Balakhonov S.V., Korzun V.M., eds. Mountain-Altai natural plague focus: retrospective analysis, epizootological monitoring, current state. Novosibirsk: Nauka-Center [Science Center]; 2014 (in Russian).

5. Kutyrev V.V., Popova A.Yu., Ezhlova E.B., Demina Yu.V., Pakskina N.D., Shchuchinov L.V. et al. A human plague infection in the Gorno-Altai high-mountainous natural focus in 2014. Report 1. Epidemiological and epizootiological peculiarities of plague manifestations in the Gorno-Altai high-mountainous (Sailyugemsk) natural plague focus. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2014; 4: 9 – 16 (in Russian).

6. Korzun V.M., Balakhonov S.V., Chipanin E.V., Denisov A.V., Mikhailov E.P., Mishchenko A.I. et al. A natural plague focus in Gornyi Altai: formation, development and functioning. Med. Parasitol. i Parasit. Bolesni. [Medical Parasitology and Parasitic Diseases]. 2016; 1: 17 – 25 (in Russian).

7. Balakhonov S.V., Popova A.Yu., Mishchenko A.I., Mikhailov E.P., Ezhlova E.B., Demina Yu.V. et al. A case of human plague in Kosh-Agach district of Republic Altai in 2015. Report 1. Clinical-epidemiological and epizootological aspects. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2016; 1: 55 – 60 (in Russian).

8. Balakhonov S.V., Afanas’ev M.V., Shestopalov M.Yu., Ostyak A.S., Vityazeva S.A., Korzun V.M. et al. The first case of Yersinia pestis subsp. pestis isolation in Altai mountainous natural plague focus. Report 1. Microbiological characteristics, molecular-genetic and mass-spectrometric identification of the isolate. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2013; 1 (115): 60 – 65 (in Russian).

9. Kosilko S.A., Balakhonov S.V., Korzun V.M., Chipanin E.B., Denisov A.V., Mikhailov E.P. et al. Current epidemiological-epizootological condition in Gorno-Altai natural plague focus. Actual problems of diseases common for humans and animals: Proceedings of All-Russian Sci.-Pract. Conf. with Intern. Participation. Stavropol; 2012: 46 (in Russian).

10. Balakhonov S.V., Korzun V.M., Verzhutsky D.B., Mikhailov E.P., Rozhdestvensky E.N., Denisov A.V. The first case of Yersinia pestis subsp. pestis isolation in the Altai mountainous natural plague focus. Report 2. Probable ways and mechanisms of plague agent basic subspecies importation into territory of the focus. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2013; 2 (116): 5 – 10 (in Russian).

11. Kutyrev V.V., Popova A.Yu., Ezhlova E.B., Demina Yu.V., Pakskina N.D., Sharova I.N. et al. A human plague infection in the Gorno-Altai high-mountainous natural focus in 2014. Report 2. Peculiarities of laboratory diagnostics and molecular-genetic characterization of the isolated strains. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2014; 4: 43 – 51 (in Russian).

12. Maramovich A.S., Kosilko S.A., Voronova G.A., Innokenteva T.I., Basanova L.P., Nikitin A.Ya. et al. Epidemiological explanation of sanitary protection of Siberia territory from plague importation from Mongolia. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2007; 1 (93): 38 – 43 (in Russian).

13. Adyaasuren Z., Tserennorov D., Myagmar Zh., Gankhuyag Ts., Otgonbayar D., Bayar Ts. et al. Current situation in natural plague foci in Mongolia. Far Eastern Zhurn. Infekt. Patologii. [Far East Journal of Infectious Diseases]. 2014; 25: 22 – 25 (in Russian).

14. Golubinsky E.P., Zhovtyi I.F., Lemesheva L.B. About plague in Siberia. Irkutsk: Irkutsk State University; 1987 (in Russian).

15. Strategy of social-economic development of Republic Altai till 2028. Available at: http://www.city-strategy.ru/upload/document/Resp_Altai_strategy 2028.pdf.

16. Nekipelov N.V. Plague epizootology in Mongolian People Republic. Izvestiya of Irkutsk Antiplague Institute. [News of Irkutsk Anti-Plague Institute]. 1959; 22: 108 – 243.

17. Bibikov D.I., Berendyaev S.A., Peisakhis L.A., Shwarts E.A. Natural plague foci in marmots in the USSR. Moscow: Meditsina. [Medicine]; 1973.

18. Nikitin A.Ya., Maramovich A.S., Kosilko S.A., Innokenteva T.I., Basanova L.P., Balakhonov S.V. et al. Epizootological characterization of natural plague foci in Mongolia in connection with development of protective measures from importation and dissemination of the infection in Russia. Probl. Osobo Opasn. Infek. [Problems especially dangerous infections]. 2007; 2 (94): 28 – 33.

19. Verzhutsky L.B. Spatial organization of a host and its ectoparasite populations. Saarbrucken: Palmarium Academic Publishing; 2012.