Experimental Approaches to the Development of Inactivated Poliovirus Vaccine Based on Sabin Strains
https://doi.org/10.31631/2073-3046-2016-15-4-59-64
Abstract
The results of development of experimental series of inactivated poliovirus vaccine based on Sabin strains (s-IPV) using conventional modern techniques are presented. Comparative analysis of immunogenicity of the experimental s-IPV and commercial IPV prepared from «wild» poliovirus strains (Imovax, Sanofi Pasteur S.A., France) using several models of laboratory animals showed their identity regarding Sabin and «wild» strains. Original method (an ELISA using specific chicken egg yolk antibodies of class Y-IgY) for quantitative determination of D-antigen in elaboration of vaccine formulation has been developed and protected by patent; conventional control methods in accordance with the WHO and European Pharmacopoeia requirements have been adopted. Finally, at experimental level it was shown that basic characteristics of the s-IPV are comparable with those of commercial IPV prepared from «wild» poliovirus strains
About the Authors
A. P. Ivanov
ФГУП «Предприятие по производству бактерийных и вирусных препаратов Института полиомиелита и вирусных энцефалитов им. М.П. Чумакова
Russian Federation
Russian Federation
T. D. Klebleeva
ФГУП «Предприятие по производству бактерийных и вирусных препаратов Института полиомиелита и вирусных энцефалитов им. М.П. Чумакова
Russian Federation
Russian Federation
O. E. Ivanova
ФГБНУ «Институт полиомиелита и вирусных энцефалитов им. М.П. Чумакова»
Russian Federation
Russian Federation
E. G. Ipatova
ФГУП «Предприятие по производству бактерийных и вирусных препаратов Института полиомиелита и вирусных энцефалитов им. М.П. Чумакова
Russian Federation
Russian Federation
L. V. Gmyl
ФГУП «Предприятие по производству бактерийных и вирусных препаратов Института полиомиелита и вирусных энцефалитов им. М.П. Чумакова
Russian Federation
Russian Federation
A. A. Ishmuhametov
ФГУП «Предприятие по производству бактерийных и вирусных препаратов Института полиомиелита и вирусных энцефалитов им. М.П. Чумакова
Russian Federation
Russian Federation
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Review
For citations:
Ivanov A.P., Klebleeva T.D., Ivanova O.E., Ipatova E.G., Gmyl L.V., Ishmuhametov A.A. Experimental Approaches to the Development of Inactivated Poliovirus Vaccine Based on Sabin Strains. Epidemiology and Vaccinal Prevention. 2016;15(4):59-64. (In Russ.) https://doi.org/10.31631/2073-3046-2016-15-4-59-64
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