Epidemiology of the most Prevalent Cancers in Ninewa between 2017–2021
https://doi.org/10.31631/2073-3046-2024-23-6-34-46
Abstract
Purpose. Cancer is characterized by abnormal cell growth resulting from uncontrolled cell division. These cells spread and form metastatic lesions in normal tissues, leading to loss of tissue and organ function. Cancer is one of the most life-threatening diseases worldwide that develops in humans. regardless of sex, ethnicity, or nationality.
Material and methods. Here, we conducted a retrospective study to collect data on the various types of cancers prevalent in Ninewa, Iraq, between 2017–2021, using hospital records pooled in the Iraq Cancer Registry. We focused on the top 10 most notable cancers prevalent in humans.
Results. Our study revealed that number of novel cancer cases and mortality rates have been increasing annually between 2017– 2021. Females had higher rates of cancer occurrence than males. The most prevalent cancers in Ninewa were breast cancer in women and lung cancer in men. Leukemia was the most common pediatric cancer. Furthermore, this study reported that lung cancer had the highest mortality rate in Ninewa, followed by breast cancer.
Conclusion Our study provides a statistical overview on cancer cases in the Ninewa governorate, and will be useful to clinicians, faculty members and other professionals in the medical field.
About the Authors
F. H. Khathayer
University of Mosul
Iraq
Iraq
Firas Hameed Khathayer – Department of Biology
+9647718629224
M. H. Mikael
University of Mosul
Iraq
Iraq
Mohammed Hussein Mikael – Department of Biology
+9647730073775
S. Z. Kadhim
State University, Stillwater
United States
United States
Sabah Zyara Kadhim – Department of Emergency Locum Veterinarian, Veterinary Medical Teaching Hospital
Stillwater, Oklahoma+18037438357
References
1. Akinde OR, Phillips A A, Oguntunde, OA,and Afolayan OM (2015). Cancer mortality pattern in lagos university teaching hospital, lagos, Nigeria. Journal of cancer epidemiology, 2015, 842032. https://doi.org/10.1155/2015/842032
2. Akinyemiju, T (2018). Epigenetic Biomarkers in Cancer Epidemiology, Editor(s): Sabita Saldanha, In Translational Epigenetics, Epigenetic Mechanisms in Cancer, Academic Press, Volume 3, Pages 223-241,
3. Ala’din A. 2nd edition. Baghdad: Ministry of Health; 2004. Dec, MD, FRCP, FFPH. Health in Iraq, the Current situation, our vision for the future and areas of work.
4. Al-Hashimi MM, Wang X.(2013). Comparing the cancer in Ninewa during three periods (1980-1990, 1991-2000, 2001-2010) using Poisson regression. J Res Med Sci. 18(12):1026-39. PMID: 24523792; PMCID: PMC3908522.
5. Alkhayatt, TN , Ali, ZA and Younis AH, (2021). The prevalence and pattern of leukemia among children in Mosul, Iraq. Teikyo medical journal 44, (06), 4653-4657.
6. Ervik M, Lam F, Ferlay J, et al.(2018). Cancer Today. Lyon, France: International Agency for Research on Cancer; 2016
7. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86. doi: 10.1002/ijc.29210
8. Hussain AM, Lafta RK.(2021). Cancer Trends in Iraq 2000-2016. Oman Med J. 36(1):e219. doi: 10.5001/omj.2021.18. PMID: 33552559; PMCID: PMC7847549.
9. International Organization for Migration (2019). Rural areas in Ninewa, International Zone, Baghdad/Iraq
10. M-Amen K, Abdullah OS, Amin AMS, et al.(2022). Cancer Incidence in the Kurdistan Region of Iraq: Results of a Seven-Year Cancer Registration in Erbil and Duhok Governorates. Asian Pac J Cancer Prev. 2022;23(2):601-615. Published 2022 Feb 1. doi:10.31557/APJCP.2022.23.2.601
11. Mattiuzzi C, Lippi G.(2019). Current Cancer Epidemiology. J Epidemiol Glob Health. 9(4):217-222. doi: 10.2991/jegh.k.191008.001. PMID: 31854162; PMCID: PMC7310786.
12. Oliveria SA, Christos PJ, Berwick M.(1997). The role of epidemiology in cancer prevention. Proc Soc Exp Biol Med. 216(2):142-50. doi: 10.3181/00379727-216-44164. PMID: 9349683.
13. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F.(2020). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. PMID: 33538338.
14. WHO IARC.(2018). Estimated Cancer Incidence, Mortality and prevalence worldwide in 2012.fact sheet. Population fact sheet. 2018
15. Abulkhair O, Saadeddin A, Makram O, Gasmelseed A, Pasha T, Shehata H, Fakhoury HM.(2016). Vitamin D levels and breast cancer characteristics: Findings in patients from Saudi Arabia. J Steroid Biochem Mol Biol. 164:106-109. doi: 10.1016/j.jsbmb.2015.11.003. Epub 2015 Nov 7. PMID: 26554935.
16. Al Balawi IA, Mir R, Abu-Duhier FM.(2018). Potential impact of vascular endothelial growth factor gene variation (−2578C> A) on breast cancer susceptibility in Saudi Arabia: a case-control study. Asian Pac J Cancer Prev. 19:1135–1143.
17. Alhuquail AJ, Alzahrani A, Almubarak H, et al. (2018).High prevalence of deliterous BRCA 1 and BRCA 2 germline mutations in arab breast and ovarian cancer patients. Breast Cancer Res Treat. 2018
18. Alqahtani WS, Almufareh NA, Domiaty DM, et al.(2020). Epidemiology of cancer in Saudi Arabia thru 2010-2019: a systematic review with constrained meta-analysis. AIMS Public Health. 7(3):679-696. Published 2020 Sep 11. doi:10.3934/publichealth.2020053
19. Alwan N, Kerr D.(2018). Cancer control in war-torn Iraq. Lancet Oncol. 19:291–2. doi: 10.1016/S1470-2045(18)30135-9.
20. American cancer society (2020). Childhood Leukemia Causes, Risk Factors, and Prevention. Cancer.org. USA . https://www.cancer.org/cancer/types/leukemia-in-children/about/new-research. html
21. Cancer research UK (2023). Risks and causes of lung cancer. England and Wales
22. Farmer P, Frenk J, Knaul FM, Shulman LN, Alleyne G, Armstrong L, et al.(2010). Expansion of cancer care and control in countries of low and middle income: A call to action. Lancet. 376:1186–93. doi: 10.1016/S0140-6736(10)61152-X.
23. Fathi RA, Matti LY, Al-Salih HS, (2013).Godbold D. Environmental pollution by depleted uranium in Iraq with special reference to Mosul and possible effects on cancer and birth defect rates. Med Confl Surviv 29(1):7-25 . 10.1080/13623699.2013.765173
24. Fuliful FK, Ali RHA. and Ali,KHA (2021). A Statistical Analysis on the Incidence Rate of Lung Cancer in Karbala-Iraq during 2012-19, International Journal of Medical Research & Health Sciences, 10(3): 40-52
25. Habib SO, Hameed AL, Ajeel AN, Al-Hawaz MH, Al-Faddagh ZA, Nasr NG, et al. (2016).Epidemiology of breast cancer among females in Basrah. Asian Pac J Cancer Prev. 17:191–5. doi: 10.7314/apjcp.2016.17.s3.191.
26. Hamadeh RR, Borgan SM, Sibai AM.(2017). Cancer research in the Arab world: A review of publications from seven countries between 2000–2013. Sultan Qaboos Univ Med J. 17:e147–54. doi: 10.18295/squmj.2016.17.02.003
27. Hussain AM, Lafta RK.(2021). Cancer Trends in Iraq 2000-2016. Oman Med J. 36(1):e219. Published 2021 Jan 31. doi:10.5001/omj.2021.18
28. Ibrahim BA, Al-Humaish S and Al-Obaide MAI (2018). Tobacco Smoking, Lung Cancer, and Therapy in Iraq: Current Perspective. Front. Public Health 6:311. doi: 10.3389/fpubh. 2018 .00311
29. Ifediora CO.(2019). Re-thinking breast and cervical cancer preventive campaigns in developing countries: the case for interventions at high schools. BMC Public Health. 3;19(1):503. doi: 10.1186/s12889-019-6890-2. PMID: 31053073; PMCID: PMC6500011.
30. Kim, H. I., Lim, H., & Moon, A. (2018). Sex Differences in Cancer: Epidemiology, Genetics and Therapy. Biomolecules & therapeutics, 26(4), 335–342.
31. Mir R, Javid J, Al Balawi A, et al.(2018). A germline mutation in BRCA1 3’UTR variant predicts susceptibility to breast cancer in a Saudi Arabian population. Asian Pac J Cancer Prev. 19:859–866.
32. Mojsak D, Dębczyński M, Kuklińska B, et al.(2023). Impact of COVID-19 in Patients with Lung Cancer: A Descriptive Analysis. Int J Environ Res Public Health. 20(2):1583. Published 2023 Jan 15. doi:10.3390/ijerph20021583
33. Noronha V, Pinninti R, Patil VM, Joshi A, Prabhash K.(2016). Lung cancer in the Indian subcontinent. South Asian J Cancer. 5(3):95-103. doi:10.4103/2278-330X.187571
34. Prager GW, Braga S, Bystricky B, Qvortrup C, Criscitiello C, Esin E, et al.(2018). Global cancer control: Responding to the growing burden, rising costs and inequalities in access. ESMO Open. 3:e000285. doi: 10.1136/esmoopen-2017-000285.
35. Pramesh, C.S., Badwe, R.A., Bhoo-Pathy, N. et al.( 2022).Priorities for cancer research in low- and middle-income countries: a global perspective. Nat Med 28, 649–657 .Apr;28(4):649-657.
36. doi: 10.1038/s41591-022-01738-x.
37. Rahman S, Zayed H. (2018).Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRCA1/2 genes. Gene. 20;668:73-76. doi: 10.1016/j.gene.2018.05.045. Epub 2018 May 17. PMID: 29777908.
38. Reyes R., López-Castro R., Auclin E., García T., Chourio M.J., Rodriguez A., López L., Laguna J.C., Lucena C., Molins L., et al(2021).. MA03.08 Impact of COVID-19 Pandemic in the Diagnosis and Prognosis of Lung Cancer. J. Thorac. Oncol. 2021;16:S141.
39. Saeed, S. M.,(2009). Epstein-Barr virus in Hodgkin’s lymphoma-immunohistochemical case series study. Annals of the College of Medicine, Mosul, 2009. 35(2): p. 93-103.
40. Safiri, S., Noori, M., Nejadghaderi, S. et al. Burden of female breast cancer in the Middle East and North Africa region, 1990–2019. Arch Public Health 80, 168 (2022).
41. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29. doi: 10.3322/caac.20138.
42. Wang Y, Freemantle N, Nazareth I, Hunt K. Gender differences in survival and the use of primary care prior to diagnosis of three cancers: An analysis of routinely collected UK general practice data. PLoS One. 2014;9:e101562. doi: 10.1371/journal.pone.0101562.
43. Yue W, Wang JP, Li Y, et al. Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms. Int J Cancer. 2010;127(8):1748-1757. doi:10.1002/ijc.25207
Review
For citations:
Khathayer F.H., Mikael M.H., Kadhim S.Z. Epidemiology of the most Prevalent Cancers in Ninewa between 2017–2021. Epidemiology and Vaccinal Prevention. 2024;23(6):34-46. (In Russ.) https://doi.org/10.31631/2073-3046-2024-23-6-34-46
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