Preventive Rotavirus Vaccination in a Defined Region: Implementation Under the Regional Immunization Schedule
https://doi.org/10.31631/2073-3046-2026-25-48-53
Abstract
Relevance. Rotavirus infection remains epidemiologically and economically significant to this day. Aim. To evaluate the preventive effectiveness of the rotavirus vaccine in the vaccination of young children. Materials and methods. This article presents a comparative analysis of rotavirus enteritis incidence across different age groups in the municipal district of «Berezniki City» during the pre-mass vaccination (2010–2018) and mass vaccination (2019–2024) periods. The comparison region was the Kudymkarsky Municipal District, where rotavirus immunization was not implemented. Results and discussion. The findings demonstrate a significant decrease in rotavirus enteritis incidence among residents of the «Berezniki City» municipal district during the mass vaccination period compared to the pre-vaccination era, confirming the high preventive efficacy of rotavirus enteritis immunization. Conclusion. The obtained data support the necessity of introducing mass vaccination against rotavirus infection in first-year infants within specific regions as the most effective tool for reducing morbidity and improving the epidemiological situation.
About the Authors
S. A. Bujanow
Federal Budgetary Healthcare Institution «Center for Hygiene and Epidemiology in the Perm Region»
Russian Federation
Russian Federation
Stefan A. Bujanow – Epidemiologist
50, Kuibyshev str., Perm, 614016
+7 (342) 291-95-66
V. V. Semerikov
Federal State Budgetary Educational Institution of Higher Education «Perm State Pharmaceutical Academy» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Vadislav V. Semerikov – Dr. Sci. (Med.), Head of the Epidemiological Department of the Perm Regional Clinical Infectious Diseases Hospital, Chief Freelance Epidemiologist Ministry of Health of the Perm Region; Professor of the Department of Extreme Medicine and Commodity Science
96, Pushkin Street, Perm, 614000
+7 (342) 236-46-15
N. B. Voldsсhmidt
The Perm Region Office of Rospotrebnadzor
Russian Federation
Russian Federation
Natalia B. Voldschmidt – Cand. Sci. (Med.), Deputy Head of the Department of Epidemiological Surveillance
50, Kuibyshev str., Perm, 614016
+7 (342) 236-51-90
References
1. On the State of Sanitary and Epidemiological Well-being of the Population in the Russian Federation in 2024: State Report. Moscow: Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor); 2025. 424 p. (In Russ.)
2. Kudryavtsev VV, Mindlina AY, Gerasimov AN, et al. Prevalence and main manifestations of rotavirus infection morbidity in different world regions. Pediatric Pharmacology. 2013;10(4):38-44. (In Russ.) https://doi.org/10.15690/pf.v10i4.753
3. Kudryavtsev VV, Mindlina AY, Gerasimov AN, et al. Features of the epidemic process development in rotavirus infection. Sanitary Doctor. 2013;(12):36-42. (In Russ.)
4. Belyaev AL. Gastroenteritis of rotavirus etiology. Medical Nurse. 2007;(4):16-19. (In Russ.)
5. Vaccine Prevention of Rotavirus Infection in Children: Federal Clinical Guidelines. Ministry of Health of Russia, Union of Pediatricians of Russia. Moscow: Pediatrician; 2017:1-27. (In Russ.).
6. Decree of the Government of the Russian Federation No. 2390-r of September 18, 2020 «On approval of the Strategy for the Development of Immunoprophylaxis of Infectious Diseases for the Period up to 2035». Collection of Legislation of the Russian Federation. 2020;40:6298. (In Russ.).
7. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-1544. doi:10.1016/S0140-6736(16)31012-1
8. Rudakova AV, Kharit SM, Uskov AN. Evaluation of prevented costs for rotavirus infection therapy when using pentavalent vaccine in the Russian Federation. Journal Infectology. 2014;6(2):71-75. (In Russ.)
9. World Health Organization. Rotavirus vaccines: WHO position paper – November 2022. Wkly Epidemiol Rec. 2022;97(47):561-580.
10. World Health Organization. Global rotavirus surveillance network. Wkly Epidemiol Rec. 2023;98(47):561-580.
11. Belyakov VD, Yafaev RH. Epidemiology: Textbook for Students of Sanitary Faculties of Medical Institutes. Moscow: Medicina; 1989. (In Russ.).
12. Shanygin SI. Correlation and Regression Analysis: Textbook for Universities. Kovalev VV, editor. Moscow: Yurait Publishing House; 2025. 70 p. (In Russ.).
13. Kulkarni PS, Desai S, Tewari T, et al. A randomized Phase III clinical trial to assess the efficacy of a bovine-human reassortant pentavalent rotavirus vaccine in Indian infants. Vaccine. 2017;35(45):6228-6237. doi:10.1016/j.vaccine.2017.09.014
14. Isanaka S, Guindo O, Langendorf C, et al. Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger. N Engl J Med. 2017;376(12):1121-1130. doi:10.1056/NEJ-Moa1609462
15. Coldiron ME, Guindo O, Makarimi R, et al. Safety of a heat-stable rotavirus vaccine among children in Niger: Data from a phase 3, randomized, double-blind, placebocontrolled trial. Vaccine. 2018;36(25):3674-3680. doi:10.1016/j.vaccine.2018.05.023
16. Luhata Lungayo C, Burnett E, Mulumba A, et al. Rotasiil vaccine effectiveness against rotavirus-associated hospitalizations in the Democratic Republic of the Congo: comparison of multivariate logistic regression and inverse probability treatment weighting methods in a test-negative design. Vaccine. 2025;68:127944. doi:10.1016/j.vaccine.2025.127944
17. Ponomareva E.N., Polibin R.V., Pakskina N.D., et al. Gorodin V.N., Malinnikova E.Yu. Analysis of Approaches to the Development of Regional Calendars of Preventive Vaccinations against current infections in the constituent entities of the Russian Federation. Epidemiology and Vaccinal Prevention. 2025;24(3):94-102. (In Russ.) https://doi.org/10.31631/2073-3046-2025-24-3-94-102
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For citations:
Bujanow S.A., Semerikov V.V., Voldsсhmidt N.B. Preventive Rotavirus Vaccination in a Defined Region: Implementation Under the Regional Immunization Schedule. Epidemiology and Vaccinal Prevention. 2026;25(1):48-53. (In Russ.) https://doi.org/10.31631/2073-3046-2026-25-48-53
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