Таргетное секвенирование в диагностике инфекционных заболеваний: современное состояние и перспективы
https://doi.org/10.31631/2073-3046-2026-25-1-111-120
Аннотация
Актуальность. Таргетное секвенирование постепенно занимает все более важное место в диагностике инфекционных заболеваний на фоне ряда ограничений традиционных методов и высокой стоимости/сложности метагеномного секвенирования. Цель. Обобщить современные подходы к таргетному NGS в диагностике инфекций, показать его преимущества и ограничения, по сравнению с культуральными и ПЦР-методами, а также с метагеномным секвенированием, и обсудить перспективы внедрения в рутинную практику и систему геномного эпиднадзора. Заключение. Показано, что таргетное секвенирование, при сопоставимых с традиционными методами сроках и стоимости, позволяет существенно повышать чувствительность и специфичность выявления возбудителей, точно типировать патогены и одновременно получать данные, пригодные для эпиднадзора и мониторинга устойчивости к противомикробным препаратам. Обсуждаются ключевые технологические и организационные барьеры, а также направления развития панелей и биоинформатических решений, которые способны сделать таргетное NGS одним из базовых инструментов инфекционной диагностики в ближайшие годы.
Об авторах
М. И. Надтока
ФБУН Центральный НИИ Эпидемиологии Роспотребнадзора
Россия
Россия
Максим Игоревич Надтока – научный сотрудник
+7 (916)080-97-50
Москва
Г. В. Роев
ФБУН Центральный НИИ Эпидемиологии Роспотребнадзора;
ФГАОУ ВО «Московский физико-технический институт (национальный исследовательский университет)»
Россия
Россия
Герман Викторович Роев – биоинформатик; аспирант
+7 (925) 440-35-50
Москва
К. Ф. Хафизов
ФБУН Центральный НИИ Эпидемиологии Роспотребнадзора
Россия
Россия
Камиль Фаридович Хафизов – заведующий лабораторией
+7 (917) 597-20-85
Москва
В. Г. Акимкин
ФБУН Центральный НИИ Эпидемиологии Роспотребнадзора
Россия
Россия
Василий Геннадьевич Акимкин – директор
Москва
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Рецензия
Для цитирования:
Надтока М.И., Роев Г.В., Хафизов К.Ф., Акимкин В.Г. Таргетное секвенирование в диагностике инфекционных заболеваний: современное состояние и перспективы. Эпидемиология и Вакцинопрофилактика. 2026;25(1):111-120. https://doi.org/10.31631/2073-3046-2026-25-1-111-120
For citation:
Nadtoka M.I., Roev G.V., Khafizov K.F., Akimkin V.G. Targeted Sequencing in Infectious Disease Diagnostics: Current State and Future Prospects. Epidemiology and Vaccinal Prevention. 2026;25(1):111-120. (In Russ.) https://doi.org/10.31631/2073-3046-2026-25-1-111-120
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