Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations
https://doi.org/10.31631/2073-3046-2017-16-3-84-88
Abstract
Dynamics of acidic and alkaline phosphatase activities was examined in thymus and spleen of laboratory mice immunized by cell wall preparations of Francisella tularensis of different subspecies. Cell wall preparations of two subspecies: F. tularensis subsp. mediaasiatica А-61(385) and F. tularensis subsp. novicida В-399 A-Cole (386) stimulated the rise of acidic and alkaline phosphatase activities in earlier time (7 days) after immunization than the others. It was correlated with their protective activity. On the basis of the results it is concluded that the studying of the acidic and alkaline phosphatase activities in immunocompetent organs can serve as one of the criteria for evaluation of efficiency of immunobiological preparations.
Keywords
туляремия,
клеточная стенка,
фосфатаза,
тимус,
селезенка,
Francisella tularensis,
cell wall,
phosphatase,
thymus,
spleen
About the Authors
O. V. Yurieva
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
V. I. Dubrovina
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
A. V. Korneva
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
T. P. Starovoitova
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
T. A. Ivanova
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
V. B. Nikolaev
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
S. V. Balakhonov
Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer Rights
Russian Federation
Russian Federation
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Review
For citations:
Yurieva O.V., Dubrovina V.I., Korneva A.V., Starovoitova T.P., Ivanova T.A., Nikolaev V.B., Balakhonov S.V. Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations. Epidemiology and Vaccinal Prevention. 2017;16(3):84-88. (In Russ.) https://doi.org/10.31631/2073-3046-2017-16-3-84-88
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