The State of Specific Immunity to Measles and Rubella Virus in Newborns and their mothers

Objective: evaluate the passive specific immunity to measles and rubella in newborns and their mothers. Materials and metods: a study was made by the ELISA of the state of specific immunity to measles and rubella in 226 puerperas aged 15 to 44 without taking into account the vaccination status and their newborns in maternity hospitals in Moscow and Moscow Region. Results - the seropositive of measles proportion - 73.9 ± 2.9%, the rubella - 84.5 ± 2.4%. Comparison of the results of the study of immunity to rubella in puerperas and newborns with the results of previous years did not reveal any significant differences. The results of the examination of 226 newborns for the presence of antibodies to the rubella virus showed that the proportion of seropositive measles to the virus turned out to be 177 (78.3 ± 2.7%) children, rubella - 83.6 ± 2.4%, comparable to results of a survey of their mothers. Conclusion: high level of protection of the puerperas and their newborns from these infections. However, the organization and carrying out of vaccinations requires increased attention and control, since only high and timely coverage with vaccinations will prevent the increase in the incidence of infection when meeting with the pathogen of infection, including children of the first year of life.

антитела, иммунитет, корь, краснуха, новорожденные, antibodies, immunity, measles, rubella, newborns

1. Tikhonova N. T., Gerasimova A. G., Tsvirkun O. B., Yezhlova E. B., Shulga S. V., Mamaeva T. A., Turaeva N. V. The causes of the increase in the incidence of measles in Russia during the elimination of infection. Pediatria. Zhurnal imeni Speranskogo. [Journal «Pediatria» named after G. N. Speransky]. 2013; 1: 9 –14 (in Russian).

2. Petrukhina M. I., Starostina N. V. Statistical methods in epidemiological analysis. Moscow: Petit-A; 2003 (in Russian).

3. Obstetrics: national leadership. Ed.: E. C. Ailamazyan. Moscow: GEOTAR-Media; 2009 (in Russian).

4. Bolotovskiy V. M., Zargaryants A. I., Titova N. S., Chistyakova B. G., Zakharova T. R., Lemesheva N. I. Indicators of anticorrugal humoral immunity of newborns, depending on the anamnesis of the puerperas. Pediatria. Zhurnal imeni Speranskogo. [Journal «Pediatria» named after G. N. Speransky]. 1985; 9: 58–59 (in Russian).

5. Sohin A. A., Slyusar L. I., Ignatov S. A., Mehova L. S. Effectiveness of immunoprophylaxis of measles and criteria for assessing the possibility of its elimination. Zhurnal mikrobioligii, epidemiologii i immunologii. [Journal of Microbiology, Epidemiology and Immunobiology]. 1986, 11: 24–30 (in Russian).

6. Gerasimova A. G., Ignatieva G. V., Sadykova D. K., Moskaleva T. N., Dubovitskaya E. L., Tsvirkun O. V. et al. The state of measles immunity in pregnant women and newborns. In Actual problems of infectious pathology. St. Petersburg; 1993 (in Russian).

7. Semerikov V. V. Serological monitoring as a basis for epidemiological surveillance of rubella infection. Doctorate of med. sci. diss. Sciences of Perm; 1995 (in Russian).

8. Kulakov V. I., Ordzhonikidze N. V., Tyutyunnik V. L. Placentar deficiency and infection. Moscow; 2004 (in Russian).

9. Bocharova A. I., Kostinov M. P., Novikova S. V., Shmitko A. D., Obidina A. A., Tsivtsivadze E. B. Transplacental antibodies to measles virus in newborns in different pregnancy in their mothers.Rissysky vestnik akushera-ginekologf. [Russian Bulletin of the Obstetrician-Gynecologist]. 2014; 2 (14): 14–18 (in Russian).

10. Ellinger I., Fuchs R. HFcRn-madiated trasplacental immunoglobulin G transport: Protection of and thrust to the human fetus and newborn. Wien Med. Wochenschr. 2012; 162 (9–10): 207–213.

11. Fazleeva L. K., Romanova N. A. Influence of conditions of the antenatal period of development on the formation of postvaccinal immunity in children. Immunology and immunopathological conditions in children. Moscow., 1983; 64–65 (in Russian).

12. Kostinov M. P., Shmitko A. D., Bocharova A. I., Cherdantsev A. P., Savisko A. A., Polishchuk V. B. The level of IgG antibodies to measles virus in the cord blood of newborns taking into account the age of mothers. Epidemiologiya i infektsionnye bolezni. [Epidemiology and infectious diseases]. 2014; 3: 30–34 (in Russian).

13. Sokolov D. I., Selkov S. A. Immunological control of the formation of the vascular network of the placenta: monograph. St. Petersburg; 2012 (in Russian).

14. Van den Berg J. P., Westerbeek E. A., van der Klis F. R., Berbers G. A., van Elburg R. M. Transplacental transport of IgG antibodies to preterm infants: a review of the literature. Early Human Development. 2011; 87 (2): 67–72.

15. Palmeira P., Quinello C., Silveira-Lessa A. L., Zago C. A., Carneiro-Sampaio M. IgG Placental Transfer in Healthy and Pathological Pregnancies. Clinical Developmental Immunology. 2012; 2012. [cited 23 June 2017 ] Available at: http://www.hindawi.com/journals/jir/2012/985646/.

16. National plan of measures for the implementation of the program«Elimination of measles and rubella in the Russian Federation (2016–2020)» (approved by Rospotrebnadzor on 28.12.2015, Ministry of Health of Russia 31.12.2015 ) .[cited 23 June 2017 ]; Available at: http://rospotrebnadzor.ru/deyatelnost/epidemiological-surveillance /? ELEMENT_ID = 5968 (in Russian).