The Dynamics of the Epidemiological Situation of Tick Borne Encephalitis in the Far East
https://doi.org/10.31631/2073-3046-2015-14-3-17-22
Abstract
We have presented a comparative analysis of morbidity and mortality in the tick-borne encephalitis (TBE) in the south of the Russian Far East in the period 1980 - 2014. In the period from 2008 to 2014 using the enzyme-linked immunoassay (ELISA) was examined 10,599 copies ticks or leukocyte fraction of blood (n = 5561) of people who indicate to the fact of tick bites. Blood samples and ticks positive in ELISA additionally examined by PCR and virus isolation. Under diagnosis of TBE cases in the 1980s resulted in lower figures morbidity and mortality artificially excessive to 39% (average 28%). In the 1990s there was a sharp rise in the incidence of TBE (median 15.3% mortality). In the 2000s there was a trend to a decrease in the number of cases and deaths (average case fatality rate of 6.3 -10.5%). The incidence rate for 35-year follow-up period ranged from 0.85 to 9.88 per 100 thousand population, mortality was 14.8 ± 0.7%. The degree of danger of the epidemic on TBE synchronously reflected in the rate of antigen detection of TBE virus in humans and ticks attached themselves. In the year’s high morbidity and mortality (in 2009 and 2010) antigen detection in ticks and in human blood reached a maximum. Isolated from the blood of these patients three TBE virus strains indicated that only a complete virus capable of replicating determines the variety clinical forms of the infection.
About the Author
G. N. Leonova
Federal State Budgetary Institution of a Science «Research Institute of Epidemiology and Microbiology named of G.P. Somov»
Russian Federation
Russian Federation
References
1. Tatarinova L.G. Characteristics of the centers of tick-borne encephalitis in the Primorye Territory: Doctorate of med. sci. diss. Leningrad; 1962 (in Russian).
2. Zilber L.A. Spring (spring-summer) epidemical tick-borne encephalitis. Arch. Biol. Nauk; 1939; 56 (2): 9 −– 37 (in Russian).
3. Charrel R.N., Attoui H., Butenko A.M., Clegg J.C. Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect 2004; 10 (12): 1040−– 1055.
4. Ecker M., Allison S.L., Meixner T., Heinz F.X. Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia. J Gen Virol. 1999; 80: 179 – 185.
5. King M.Q.A., Adams M.J., Carstens E.B., Lefkowitz E.J., ed. Virus taxonomy: classification and nomenclature of viruses: ninth report of the international on committee on taxonomy of viruses. San Diego. Elsevier; 2012: 1003 −– 1020.
6. Loktev V.B., Ternovoy V.A., Netyosov C.B. Molecular genetic characterization of tick-borne encephalitis virus. Vopr. virusol. 2007; 5: 10 – 16 (in Russian).
7. Dumpis U., Crook D., Oksi J. The tick-borne encephalitis. Clinical infectious Diseases. 1999; 28: 882 – 890.
8. Gritsun T.S., Frolova T.V., Zhankov A.I., Armesto M., Turner S.I., Frolova M.P. et al. Gould characterization of a siberian virus isolated from a patient with progressive chronic tick-borne Encephalitis. J. of Virology. 2003; 77 (1): 25−– 36.
9. Leonova G.N. Tick-borne encephalitis: current aspects. Moscow; 2009: 168 (in Russian).
10. Pogodina V.V., Bochkova N.G., Levina L.S., Malenko G.V., Andaev E.I., Karan' L.S. et al. Evolution of tick-borne encephalitis. Vopr. virusol. 2007; 5: 16 −– 21 (in Russian).
11. Leonova G.N. Tick-borne encephalitis in the Primorsky region. Publishing house Dal’nauka. Vladivostok; 1997: 187 (in Russian).
12. Leonova G.N., Belikov S.I., Kondratov I.G., Takashima I. Comprehensive assessment of the genetics and virulence of tick-borne encephalitis virus strains isolated from patients with inapparent and clinical forms of the infection in the Russian Far East Virology. 2013; 443: 89 – 98.
13. Belikov S.I., Kondratov I.G., Potapova U.V., Leonova G.N. The relationship between the structure of the tick-borne encephalitis virus strains and their pathogenic properties. PLoS One. 2014 Apr. 16; 9 (4): e94946. Doi: 10.1371/journal.pone.0094946. eCollection 2014 Author information: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.009494.
14. Broker M., Gniel D. New foci of tick-borne encephalitis virus in Europe: consequences for travelers from abroad. Trevel Medicine and Inf. Dis. 2003; 1: 181 – 184.
15. Onishchenko G.G., Fedorov Yu.M., Pakskina N.D. Organization of supervision of tick-borne encephalitis and measures for its prevention in the Russian Federation Vopr. virusol. 2007; 5: 8−– 10 (in Russian).
16. Leonova G.N., Maistrovskaya O.S. Viremia in patients with tick-borne encephalitis and those with sucking ticks. Vopr. virusol. 1996; 5: 224 − 228 (in Russian).
17. Leonova G.N., Maistrovskaya O.S., Borisevich V.G. Antigenemia in people infected with tick-borne encephalitis. Vopr.virusol.1996; 6: 260 − 263 (in Russian).
18. Takashima I., Morita K., Chiba M., Hayasaka D., Sato T., Takezawa C. et al. A case of tick-borne encephalitis in Japan and isolation of the virus. J. Clin. Microbiol. 1997; 35: 1943 – 1947.
19. Heinz F.X., Kunz C. Tick-borne encephalitis and the impact of vaccination. Arch. Virol. 2004; 18: 201 – 205.
20. Kunz C. TBE vaccination and Austrian experience. Vaccine. 2003; 21: S1/50 – S1/55.
21. Romanenko V.V., Esyunin M.S., Kilyachina A.S. Experience in organizing mass immunization program against tick-borne encephalitis in the Sverdlovsk region. Vopr. virusol. 2007. 6: 22−– 25 (in Russian).
22. Korenberg E.I. Molecular Biological Methods and Study of Natural Focality Diseases. Successes of modern biology. 2012; 132 (5): 448 −– 462.
Review
For citations:
Leonova G.N. The Dynamics of the Epidemiological Situation of Tick Borne Encephalitis in the Far East. Epidemiology and Vaccinal Prevention. 2015;14(3):17-22. (In Russ.) https://doi.org/10.31631/2073-3046-2015-14-3-17-22
Views:
918
Email this article 