Epidemiological Differences of Chronic Viral Hepatitis C in Caucasian and Asian Races Taking into Account Population Interferon Gene Polymorphism

Aim of study: to give a comparative epidemiological characteristic of hepatitis C in Mongolia and Irkutsk region taking into account races, INF λ3 gene polymorphism and INF λ4 gene polymorphismin studied population. Epidemiological evidence of hepatitis C in Mongolia, in contrast to the Irkutsk region, characterized higher prevalence, domination of seropositive persons in age older than 50 years, domination in the circulation of the 1st virus genotype. In the population of Mongolia was revealed high frequency some nucleotide INF λ3 and INF λ4 gene polymorphism. These genetic markers are more favorable for natural history of hepatitis C. It explains the high rate of spontaneous hepatitis C virus clearance among people of Asian race.

гепатит С, европеоиды, монголоиды, генетический полиморфизм, ген интерферона λ3, ген интерферона λ4, hepatitis C, Caucasian, Asian, gene polymorphism, INF λ4 gene, INF λ3 gene

1. Matsuura K., Tanaka Y. Natural history of hepatitis C virus infection. Nihon Rinsho. 2015; 73 (2): 195 – 200.

2. Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin. Microbiol. Infect. 2011; 17 (2): 107 – 115.

3. Nechaev V.V., Mukomolov S.L., Nazarov V.Yu., Pozhidaeva L.N., Chakhar’yan V.V. Chronic viral hepatitides: past, present, future. Epidemiology and infectious diseases. 2013; 3: 4 – 9 (in Russian).

4. Trifonova G.F., Levakova I.A., Bolsun D.D., Mukomolov S.L. Epidemiological features of Hepatitis C virus infection in the Russian Federation in 1994 – 2013. Infection and immunity. 2014; 3: 267 – 274 (in Russian).

5. Mohd Hanafiah K., Groeger J., Flaxman A.D., Wiersma S.T. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57(4): 1333 – 1342.

6. Tsatsralt-Od B., Takahashi M., Nishizawa T. High prevalence of dual or triple infection of hepatitis B, C, and delta viruses among patients with chronic liver disease in Mongolia. J. Med. Virol. 2005; 77(4): 491-499.

7. Simon J.S., Shianna K.V., Urban T.J. et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009; 461: 399 – 401.

8. Tanaka Y., Nishida N., Sugiyama M., Kurosaki M., Matsuura K., Sakamoto N. et al. Genome-wide association of IL28B with response to pegylated interferonalpha and ribavirin therapy for chronic hepatitis C. Nat. Genet. 2009; 41 (10): 1105 – 1109.

9. Thomas D.L.,Thio C.L., Martin M.P. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009; 461: 798 – 801.

10. Jung Y.K., Kim J.H., Ahn S.M., Yang J.W., Park S.J., Kim J.W. et al. Role of interleukin 28B-related gene polymorphisms in chronic hepatitis C and the response to antiviral therapy in Koreans. J. Clin. Gastroenterol. 2013; 47 (7): 644 – 650.

11. Rangnekar A.S., Fontana R.J. Meta-analysis: IL-28B genotype and sustained viral clearance in HCV genotype 1 patients. Aliment. Pharmacol. Ther. 2012; 36 (2): 104 – 114.

12. Prokunina-Olsson L., Muchmore B., Tang W. A variant upstream of INFL3 (IL28B) creating a new interferon gene INFL4 is associated with impaired clearance of hepatitis C virus. Nature genetics. 2013; 45: 164 – 171.

13. Kruchkin Yu.N. Modern Mongolia. Encyclopedic reference. Ulaanbaatar; 2011; 1154 (in Russian).

14. The results of the All-Russia Population Census 2010 in the Irkutsk Region. Statistical Bulletin. Irkutsk: Irkutskstat; 2012: 52 (in Russian).

15. Ivashkin V.T., Yushchuk N.D., eds. Guidelines for the diagnosis and treatment of adult patients with hepatitis B and C: Clinical guidelines. Мoscow: GEOTARMedia; 2015 (in Russian).

16. European Association for Study of Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J. Hepatol. 2014; 60 (2): 392 – 420.

17. Savilov E.D., Astaf’ev V.A., Zhdanova S.N., Zarudnev E.A. Epidemiological analysis: The statistical treatment of the material. Novosibirsk: Science Center; 2011: 156 (in Russian).

18. Shakhgildyan I.V., Mikhailov M.I., Onishchenko G.G. Feature of some groups of high risk infection of virus hepatitis B, C and D. Far Eastern journal of infection pathology. 2004; 5: 3 – 12 (in Russian).

19. Baatarkhuu O., Kim do Y., Bat-Ireedui P. Current situation of hepatocellular carcinoma in Mongolia. Oncology. 2011; 1: 148 – 151.

20. Pimenov N.N., Chulanov V.P., Komarova S.V., Karandasheva I.V., Neverov A.D., Mikhailovskaya G.V. et al. Hepatitis C in Russia: current epidemiology and approaches to improving diagnosis and surveillance. Epidemiology and infectious diseases. 2012; 3: 4 – 9 (in Russian).

21. Mukomolov S.L., Tallo T., Sinaiskaya E.V., Kysly P.N., Tryfonova G.F., Gerasimova V.V. et al. Molecular epidemiology of hepatitis C in centers of hemodialysis in St. Petersburg. Journal of microbiology, epidemiology and immunobiology. 2014; 6: 27 – 34 (in Russian).

22. L’vov D.K., Samokhvalov E.I., Tsuda F. Prevalence of hepatitis C virus and distribution of its genotypes in Northern Eurasia. Arch. Virol. 1996; 141 (9): 1613 – 1622.

23. Kruglyak S.P., Makhno E.S., Samoylova H.F. Propagation of hepatitis C virus genotype in Premorsky krai. Pacific medical journal. 2009; 4: 39, 40 (in Russian).

24. Baranov A.V., Maleev V.V. Association between HCV RNA level and HCV antibodies during chronic hepatitis C. Journal of microbiology, epidemiology and immunobiology. 2009; 5: 19 – 22 (in Russian).

25. Orlova L.S. Evaluation of social and economic significance and prediction of efficacy antiviral therapy in patients with chronic hepatitis C: PhD of med. sci. diss. Irkutsk; 2008: 23 (in Russian).

26. Hanuka N., Sikuler E., Tovbin D., Mostoslavsky M., Hausman M., Orgel M. et al. C virus infection in renal failure patients in the absence of anti-hepatitis C virus antibodies. J. Viral. Hepat. 2002; 9 (2): 141 – 145.

27. Lai M.E., Origa R., Danjou F., Leoni G.B., Vacquer S., Anni F. et al. Natural history of hepatitis C in thalassemia major: a long-term prospective study. Eur. J. Haematol. 2013; 90 (6): 501 – 507.

28. Maor Y., Morali G., Bashari D., Penaranda G., Morali G., Klar R. et al. Genetic polymorphism of IL28B in hepatitis C-infected haemophilia patients in Israel. Haemophilia. 2013; 19 (1): 150 – 156.

29. Thomas D.L., Astemborski J., Rai R.M., Anania F.A., Schaeffer M., Galai N. The natural history of hepatitis C virus infection: host, viral, and environmental factors. JAMA. 2000; 284 (4): 450 – 456.

30. Stattermayer A.F., Strassi R., Maieron A., Rutter K., Stauber R., Strasser M. et al. Polymorphisms of interferon-λ4 and IL28B – effects on treatment response to interferon/ribavirin in patient with chronic hepatitis C. Aliment. Pharmacol. Ther. 2014; 39: 104 – 111.