Safety and Efficacy of a Subunit Vaccine against Flu Containing Polyoxidonium Systematic Review and Meta-Analysis of Clinical Trials
Abstract
The review presents a clinical expert meta-analysis of compliance with the basic requirements for safety and efficacy Of subunit influenza vaccine containing polymer Polyoxidonium (PO) as an adjuvant (PO-AG). The results of the meta-analysis convincingly demonstrate that a reduced HA dose in combination with the adjuvant PO is safe and low reactogenic and induces a humoral immune response comparable to that of other inactivated vaccines without adjuvant. PO-AG is safe and effective vaccine against influenza.
About the Author
R. Kompier
European consulting biotechnology company Fluconsult
Netherlands
Netherlands
Ronald Kompier – managing Director of Vaccine Consultancy in European consulting biotechnology company Fluconsult, an independent consultancy firm covering vaccines and a wide range of other biologicals
Noordwijk
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Review
For citations:
Kompier R. Safety and Efficacy of a Subunit Vaccine against Flu Containing Polyoxidonium Systematic Review and Meta-Analysis of Clinical Trials. Epidemiology and Vaccinal Prevention. 2018;17(4):92-98. (In Russ.)
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