The Study in Animal Models of Local Action, Acute and Chronic Toxicity of Inactivated Influenza Vaccine Ultriks in Syringe
https://doi.org/10.31631/2073-3046-2015-14-3-66-73
Abstract
The evaluation of acute and chronic toxicity and local effect of the inactivated influenza vaccine Ultriks in animal models (guinea pigs, mice BALB/c) was performed. No vaccine-related toxic effect after a single intraperitoneal injection, multiple intramuscular injections, and no local irritant effect after a single intramuscular injection were reported in experimental animals.
About the Authors
O. G. Kurskaya
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
K. A. Sharshov
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
A. Yu. Alekseev
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
M. A. Gulyaeva
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine», Federal State Educational Institution of Higher Professional Education «Novosibirsk National Research State University»
Russian Federation
Russian Federation
A. M. Shestopalov
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
L. V. Shestopalova
Federal State Educational Institution of Higher Professional Education «Novosibirsk National Research State University»
Russian Federation
Russian Federation
G. M. Ignatev
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
V. A. Shkurupiy
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
References
1. Zaytsev A.A. Treatment of acute respiratory viral infections. Lechashiy vrach. 2008; 8: 42 – 45 (in Russian).
2. Osidak L.V., Drinevsky V.P., Erofeeva М.К., Eropkin М.Yu., Коnоvalova N.I., Smorodintseva E.A. et al. Influenza as a problem of the XXI century. Detskie Infectsii. 2009; 8(3): 3 – 9 (in Russian).
3. WHO. Influenza (seasonal) 2009. Available at: http://www.who.int/mediacentre/factsheets/fs211/en/index.html.
4. Harper S.A., Bradley J.S., Englund J.A., File T.M., Gravenstein S., Hayden F.G. et al, Seasonal Influenza in Adults and Children-Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management: Clinical Practice Guidelines of the Infectious Diseases Society of America. Clinical Infectious Diseases. 2009; 48: 1003 – 1032.
5. Lytkina I.N., Malyshev N.A. Prevention and treatment of influenza and acute respiratory viral infections among epidemiologically relevant groups. Lechashiy vrach. 2010; 10: 66 – 69 (in Russian).
6. Medunitsyn N.V. Vaccinology. Vol. 2nd, revised. and ext. Moscow: Triada-X; 2004 (in Russian).
7. Weekly epidemiological record, no. 43, 28 october 2005. Available at: http://www.who.int/wer
8. Donina S.A., Naikhin A.N., Grigoriev E.P., DeshevaYu.A., Barenceva I.B., Rekstin A.R. et al. The local immune response to live cold-adapted reassortant influenza vaccine in children, adults and the elderly. Voprosy Virusologii. 2003; 2: 29 – 31 (in Russian).
9. Petukhova G., Korenkov D., Chirkova T., Korenkov D., Naykhin A., Rudenko L. B- and T-cell memory elicited by a seasonal live attenuated reassortant influenza vaccine: assessment of local antibody avidity and virus-specific memory T-cells using trogocytosisbased method. Influenza and Other Respiratory Viruses. 2012; 6 (2): 119 – 126.
10. Bruljn I.A., Nauta J., Gerez L. Virosomal influenza vaccine: a save and effective influenza vaccine with high efficacy in elderly and subjects with low prevaccination titers. Virus Research. 2004; 103: 139 – 145.
11. Zverkov I.V., Erofeeva M.K., Maksakova M.L., Korovkin S.A., Mikhailova N.А., Mironov А.N. et al. Development and introduction of the new national health RF virosomal split influenza vaccine. Lechashiy vrach. 2008; 9: 68 – 70 (in Russian).
12. Markova T.P., Yarilina L.G., Kim M.N. Vaccine prophylaxis of influenza. New domestic vaccine Ultriks. Russkiy Medicinskiy Jurnal. 2014; 6: 1 – 5 (in Russian).
13. Margine I., Krammer F. Animal models for influenza viruses: implications for universal vaccine development. Pathogens. 2014; 3 (4): 845 – 874.
14. Guidelines for preclinical studies of drugs (immunobiological drugs). Eds.: A.N. Mironov, Moscow: Grief and K; 2012 (in Russian).
Review
For citations:
Kurskaya O.G., Sharshov K.A., Alekseev A.Yu., Gulyaeva M.A., Shestopalov A.M., Shestopalova L.V., Ignatev G.M., Shkurupiy V.A. The Study in Animal Models of Local Action, Acute and Chronic Toxicity of Inactivated Influenza Vaccine Ultriks in Syringe. Epidemiology and Vaccinal Prevention. 2015;14(3):66-73. (In Russ.) https://doi.org/10.31631/2073-3046-2015-14-3-66-73
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