The Study in Animal Models of Local Action, Acute and Chronic Toxicity of Inactivated Influenza Vaccine Ultriks in Syringe
https://doi.org/10.31631/2073-3046-2015-14-3-66-73
Abstract
The evaluation of acute and chronic toxicity and local effect of the inactivated influenza vaccine Ultriks in animal models (guinea pigs, mice BALB/c) was performed. No vaccine-related toxic effect after a single intraperitoneal injection, multiple intramuscular injections, and no local irritant effect after a single intramuscular injection were reported in experimental animals.
About the Authors
O. G. Kurskaya
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
K. A. Sharshov
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
A. Yu. Alekseev
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
M. A. Gulyaeva
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine», Federal State Educational Institution of Higher Professional Education «Novosibirsk National Research State University»
Russian Federation
Russian Federation
A. M. Shestopalov
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
L. V. Shestopalova
Federal State Educational Institution of Higher Professional Education «Novosibirsk National Research State University»
Russian Federation
Russian Federation
G. M. Ignatev
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
V. A. Shkurupiy
Federal State Scientific Institution «Scientific Research Institute of Experimental and Clinical Medicine»
Russian Federation
Russian Federation
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Review
For citations:
Kurskaya O.G., Sharshov K.A., Alekseev A.Yu., Gulyaeva M.A., Shestopalov A.M., Shestopalova L.V., Ignatev G.M., Shkurupiy V.A. The Study in Animal Models of Local Action, Acute and Chronic Toxicity of Inactivated Influenza Vaccine Ultriks in Syringe. Epidemiology and Vaccinal Prevention. 2015;14(3):66-73. (In Russ.) https://doi.org/10.31631/2073-3046-2015-14-3-66-73
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