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Preventive Vaccinations of Respiratory Infections during Lung Transplantation

https://doi.org/10.31631/2073-3046-2020-19-4-102-108

Abstract

Relevance. Lung transplantation is recognized as a method of treating terminal stages of lung disease when the drug therapy resource has been exhausted. In addition to the lack of material for transplantation, a serious problem of lung transplantation is the low graft survival rate. The main reasons are infections and primary allograft failure. Aims. To consider the current state of the use of vaccine prophylaxis in the integrated management of patients before and after lung transplantation. Conclusions The prevention of respiratory infections in adult candidates for organ transplantation and recipients is recommended and included in many clinical protocols and recommendations, however, they are based mainly on studies performed on healthy individuals, and are poorly supported by the results obtained in the study of individuals who underwent complete internal organ transplantation. Also, the effectiveness of vaccination remains unexplored, taking into account the individual characteristics of the immune system and the state of population immunity in relation to vaccine-preventable infections.

About the Authors

V. B. Polishchuk
I. I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation

Valentina B. Polishchuk – Cand. Sci. (Med.), Senior Researcher of Laboratory of Vaccine Prevention and Immunotherapy of Allergic Diseases

5a, Malyy Kazenny lane, Moscow, 105064. +7 (916)-564-65-48



K. V. Mashilov
I. I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation

Kirill V. Mashilov – Cand. Sci. (Med.) Associate Professor, Senior Researcher, Laboratory of Vaccine Prevention and Immunotherapy of Allergic Diseases 

5a, Malyy Kazenny lane, Moscow, 105064. +7 (9250-985-14-24



A. A. Ryzhov
I. I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation

Aleksey A. Ryzhov  – Cand. Sci. (Med.), Senior Researcher of Laboratory of Vaccine Prevention and Immunotherapy of Allergic Diseases 

5a, Malyy Kazenny lane, Moscow, 105064. +7 (926)-523-12-01



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For citations:


Polishchuk V.B., Mashilov K.V., Ryzhov A.A. Preventive Vaccinations of Respiratory Infections during Lung Transplantation. Epidemiology and Vaccinal Prevention. 2020;19(4):102-108. (In Russ.) https://doi.org/10.31631/2073-3046-2020-19-4-102-108

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