Клинические и иммунологические аспекты пневмококковой вакцинации у пациентов с множественной миеломой
Аннотация
Актуальность. Среди групп высокого риска развития инвазивных пневмококковых инфекций пациенты с множественной миеломой (ММ) выделяются одними из самых высоких показателей первичной заболеваемости и летальности по причине наличия глубокой иммуносупрессии. Цель: обозначить современное состояние проблемы вакцинопрофилактики пневмококковой инфекции у пациентов, получающих лечение по поводу множественной миеломы, обосновать доказательную базу вакцинации коньюгированной пневомококковой вакциной. В работе применялся метод сплошного обзора данных в отношении исследований на тему вакцинации против пневмококковой инфекции у пациентов с множественной миеломой. Выводы. В статье представлены современные эпидемиологические данные, а также результаты оригинальных исследований клинических и иммунологических аспектов пневмококковой вакцинации у пациентов с ММ, получающих новые таргетные агенты и иммунопрепараты. Обозначена эффективность применения коньюгированной пневмококковой вакцины у пациентов на фоне лечения ММ бор-тезомибом, леналидомидом, иксазомибом. Показано независимое защитное влияние пневмококковой вакцинации как меры профилактического воздействия в когорте пациентов с ММ на фоне лечения новыми таргетными лекарственными средствами.
Ключевые слова
Об авторе
И. О. Стома
Гомельский государственный медицинский университет
Беларусь
Беларусь
Стома Игорь Олегович – доктор медицинских наук, доцент, ректор ГомГМУ.
246000, Гомель, ул. Ланге, 5.
Тел. +375 (232) 35-98-18
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Для цитирования:
Стома И.О. Клинические и иммунологические аспекты пневмококковой вакцинации у пациентов с множественной миеломой. Эпидемиология и Вакцинопрофилактика. 2020;19(6):79-85. https://doi.org/10.31631/2073-3046-2020-19-6-79-85
For citation:
Stoma I.O. Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma. Epidemiology and Vaccinal Prevention. 2020;19(6):79-85. (In Russ.) https://doi.org/10.31631/2073-3046-2020-19-6-79-85
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