Experimental Research of the Influence of Immunomodulators on Efficiency Using of Brucellosis Living Dry Vaccine

Brucellosis living dry vaccine, used for immunization of brucellosis, has a number of drawbacks. In this regard, the article discusses the using of immunomodulators for enhance of the effectiveness of immunization and reduce of the risk of side effects and complications. Likopid, polioksidony and timogen were used as immunomodulators. As a result of valuation cellular and humoral immunity of different laboratory animals and valuation of protective efficacy of brucellosis living vaccine, the presence of a complex stimulating effect on the efficiency of immunogenesis licopid was established.

иммунопрофилактика, вакцина бруцеллезная живая сухая, эффективность иммунизации, иммуномодуляторы, ликопид, тимоген, полиоксидоний, проточная цитофлуориметрия, immunoprophylaxis, brucellosis living dry vaccine, the effectiveness of immunization, immunomodulators, likopid, timogen, polioksidony, flow cytometry

1. Cirel’son L.E. Clinical and immunological features of brucellosis on the background of specific vaccination. PhD of med. sci. diss. Alma-Ata; 1992 (in Russian).

2. Cirel’son L.E. Overview of the problems of brucellosis vaccination. Epidemiology and Vaccinal Prevention. 2013; 3 (70): 77 – 81 (in Russian).

3. Ohapkina V.Yu., Darmov I.V., Shabalin B.A. Immunization of brucellosis of human. Epidemiology and Infectious Diseases. 2007; 3: 51 – 55 (in Russian).

4. Shherbak Yu.F. Brucellosis. Moscow: Medicine; 1967 (in Russian).

5. Government Decree of July 15, 1999 № 825 «On approval of the list of jobs that are associated with a high risk of infectious diseases and requires mandatory of preventive vaccinations». Available at: http://base.garant.ru/12116330

6. MU 3.1.7.1189-03 «Prevention and laboratory diagnosis brucellosis of people». Available at: http://base.garant.ru/4183574

7. Onishhenko G.G., Cherkasskij B.L. Sanitary regulations and methodical documents. Moscow: publ. «INTERSEN»; 2006 (in Russian).

8. Jushkov V.V., Jushkova T.A. Immunodeficiencies and vaccination. Abstracts of the report II International Conference «Modern vaccinology», devoted to the 100th-anniversary of the NPO «BIOMED». Perm›: Izdatel›stvo «Zvezda»; 1998: 24 – 25 (in Russian).

9. Darmov I.V., Borisevich I.V., Pechenkin, D.V., Bogacheva N.V., Krjuchkov A.V. Dynamics of cellular immunity on introduction of plague living dry vaccine. Clinical laboratory diagnostics. 2009; 8: 24 – 27 (in Russian).

10. Funtikova T.N., Burceva N.P., Cygankova O.I. Some features of the development of immunity people which were repeatedly vaccinated by anthrax living vaccine. All-Russian Scientific Conference «Immunology and specific prevention of especially dangerous infections». Saratov; 1993: 199-200 (in Russian).

11. Kozlovsky V.N. Living tularemia and brucellosis vaccines as inducers of immunopathological reactions. PhD of med. sci. diss. Rostov-on-Don; 1997.

12. Aksenova L.Yu. Study of the major biological properties antibiotic-resistant anthrax living vaccine STI-PR during prolonged storage. Doctorate of med. sci. diss. Rostov-on-Don; 2005 (in Russian).

13. Vorob›ev A.A. Classification of principles and strategy of using immunomodulators in medicine. Journal of epidemiology and microbiology, Immunobiology. 2002; 4: 93 – 98 (in Russian).

14. Pinegin B.V., Nekrasov A.V., Haitov P.M. Immunomodulator Polioksidoniy: mechanisms of action and aspects of clinical application. Cytokines and Inflammation. 2004; 3 (3): 41 – 47 (in Russian).

15. Pinegin B.V., Hanuhova L.M., Rabinovich O.F., Andronova T.M. New aspects of clinical application licopid by diseases, associated with violation of immuniti. Medical Immunology. 1999; 3 (4): 127, 128 (in Russian).