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Experimental Research of the Influence of Immunomodulators on Efficiency Using of Brucellosis Living Dry Vaccine

https://doi.org/10.31631/2073-3046-2016-15-2-84-92

Abstract

Brucellosis living dry vaccine, used for immunization of brucellosis, has a number of drawbacks. In this regard, the article discusses the using of immunomodulators for enhance of the effectiveness of immunization and reduce of the risk of side effects and complications. Likopid, polioksidony and timogen were used as immunomodulators. As a result of valuation cellular and humoral immunity of different laboratory animals and valuation of protective efficacy of brucellosis living vaccine, the presence of a complex stimulating effect on the efficiency of immunogenesis licopid was established.

About the Authors

N. V. Bogacheva
Branch of the Federal state establishment «48 Central Research and Development Institute» Russian Federation Ministry of Defense
Russian Federation


V. Y. Okhapkina
Branch of the Federal state establishment «48 Central Research and Development Institute» Russian Federation Ministry of Defense
Russian Federation


N. V. Pyatkova
Branch of the Federal state establishment «48 Central Research and Development Institute» Russian Federation Ministry of Defense
Russian Federation


A. K. Fedotov
Branch of the Federal state establishment «48 Central Research and Development Institute» Russian Federation Ministry of Defense
Russian Federation


A. S. Kucherenko
Branch of the Federal state establishment «48 Central Research and Development Institute» Russian Federation Ministry of Defense
Russian Federation


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Review

For citations:


Bogacheva N.V., Okhapkina V.Y., Pyatkova N.V., Fedotov A.K., Kucherenko A.S. Experimental Research of the Influence of Immunomodulators on Efficiency Using of Brucellosis Living Dry Vaccine. Epidemiology and Vaccinal Prevention. 2016;15(2):84-92. (In Russ.) https://doi.org/10.31631/2073-3046-2016-15-2-84-92

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ISSN 2073-3046 (Print)
ISSN 2619-0494 (Online)