Pneumococcal Vaccine in Adults with Bronchopulmonary Pathology: from Prevention to Treatment
https://doi.org/10.31631/2073-3046-2023-22-3-93-99
Abstract
Relevance. Community-acquired pneumonia and chronic obstructive pulmonary disease (COPD) remain a serious public health problem in all respects today.
Aims. To summarize the studies of domestic authors on the study of the effect of pneumococcal polysaccharide vaccine on various parts of the immune system and their relationship with the clinical course of the disease in patients with COPD and community-acquired pneumonia. We also consider it necessary to discuss the possible mechanisms of therapeutic effects after the introduction of a monovaccine against S. pneumoniae, as well as when it is combined with vaccines against Haemophilus influenzae type b infection, and the effectiveness of various vaccination regimens, including complex ones.
Conclusions. Convincing arguments are presented proving that the introduction of vaccines against respiratory infections can have not only a reventive value, but also a therapeutic effect, accompanied by a transient restoration of the immune system parameters, as well as a reduction in the contamination or elimination of S. pneumoniae in patients with chronic pathology of the bronchopulmonary system.
About the Authors
A. M. Kostinov
I. I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
Anton M. Kostinov – Postgraduate student of the Laboratory of Allergy Diagnostics
5a, Maly Kazenny lane, Moscow, 105064, Russia
+7 (916) 618-81-05
A. A. Tarasova
Privolzhsky Research Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Alla A. Tarasova – Dr. Sci. (Med.), professor of the department of faculty and polyclinic pediatrics
10/1, Minin and Pozharsky Square, BOX-470, Nizhny Novgorod, 603950, Russia
+7 (831) 439-09-43
K. V. Mashilov
I. I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
Mashilov Kirill V., Cand. Sci. (Med.) Associate Professor, Senior Researcher, Laboratory of Vaccine Prevention and Immunotherapy of Allergic Diseases
5a, Small Kazenny lane, Moscow, 105064, Russia
+7 (925) 985-14-24
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For citations:
Kostinov A.M., Tarasova A.A., Mashilov K.V. Pneumococcal Vaccine in Adults with Bronchopulmonary Pathology: from Prevention to Treatment. Epidemiology and Vaccinal Prevention. 2023;22(3):93-99. (In Russ.) https://doi.org/10.31631/2073-3046-2023-22-3-93-99
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