Seroprevalence of Rubella Virus in Chronic Kidney Disease Patients
https://doi.org/10.31631/2073-3046-2026-25-1-33-37
Abstract
Relevance. Rubella virus is commonly associated with a minor infection, however, if transmitted during pregnancy, it can cause serious consequences which includ congenital rubella syndrome (CRS), people with chronic kidney disease (CKD) often have weakened immune systems, making it difficult for them to fight off rubella infection or receive the vaccine. As a result, determining the amount of rubella antibodies in these patients can aid in developing more effective preventative strategies. Aims. The purpose of this study was to assess and compare rubella virus antibody levels (IgM and IgG) in CKD patients and healthy controls. Materials and Methods. A case-control study design was adpted, with 180 CKD patients and 180 apparently healthy persons, serum samples were analyzed for rubella-specific IgM and IgG antibodies by using an enzyme-linked immunosorbent assay (ELISA). Results. Rubella IgM was detected in 81/180 of controls and 65/180 of CKD patients. Rubella IgG was positive in all participants (360/360, 100%). Mean IgG concentration was significantly higher in CKD patients (456.82 ± 144.90 IU/ml) than in controls (169.45 ± 117.52 IU/ml; t = 20.666, p < 0.001). Conclusion. Both CKD patients and controls tested positive for rubella IgG, while CKD patients had a lower IgM positivity rate, patients with chronic renal disease had significantly higher mean IgG titers, which could indicate changed immune regulation or changes in exposure and immunization history. These findings need careful interpretation and additional testing of rubella immunity in patients with chronic kidney disease (CKD).
About the Author
H. H. Lazim
Ibn Sina University of Medical and Pharmaceutical Sciences
Iraq
Iraq
Lazim H. H. – PhD (Microbiology), Lecturer
Baghdad
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Review
For citations:
Lazim H.H. Seroprevalence of Rubella Virus in Chronic Kidney Disease Patients. Epidemiology and Vaccinal Prevention. 2026;25(1):33-37. https://doi.org/10.31631/2073-3046-2026-25-1-33-37
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