Preventive Efficacy of an Inactivated Whole-Virion Vaccine against Coronavirus infection in volunteers aged 18–60 years

A. A. Siniugina; I. V. Gordeychuk; S. S. Andretsova; N. V. Yagovkina; A. G. Obrezan; A. G. Chuchalin; M. P. Kostinov; V. V. Popov; I. V. Feldblum; U. M. Tomaev; A. N. Galustyan; N. N. Ryndyuk; A. K. Korduban; A. A. Kovpak; G. A. Malkin; A. N. Piniaeva; Yu. Yu. Ivin; E. A. Korduban; A. A. Ishmukhametov

Epidemiology and Vaccinal Prevention
Èpidemiologiâ i vakcinoprofilaktika

ISSN 2073-3046 (Print)
ISSN 2619-0494 (Online)

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Siniugina A.A., Gordeychuk I.V., Andretsova S.S., Yagovkina N.V., Obrezan A.G., Chuchalin A.G., Kostinov M.P., Popov V.V., Feldblum I.V., Tomaev U.M., Galustyan A.N., Ryndyuk N.N., Korduban A.K., Kovpak A.A., Malkin G.A., Piniaeva A.N., Ivin Yu.Yu., Korduban E.A., Ishmukhametov A.A. Preventive Efficacy of an Inactivated Whole-Virion Vaccine against Coronavirus infection in volunteers aged 18–60 years. Epidemiology and Vaccinal Prevention. 2026;25(2):84-111. (In Russ.) https://doi.org/10.31631/2073-3046-2026-26-2-84-111

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ISSN 2073-3046 (Print)
ISSN 2619-0494 (Online)

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About the Authors

A. A. Siniugina
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Aleksandra A. Siniugina – Cand. Sci. (Med.), Head of Quality and Innovation Development

Moscow

I. V. Gordeychuk
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis); Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Moscow

S. S. Andretsova
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Svetlana S. Andretsova – Junior researcher at the Laboratory for Modeling Immunobiological Processes with the Experimental Clinic of Igruncov Monkeys

Moscow

N. V. Yagovkina
Federal State Budgetary Educational Institution of Higher Education «Kirov State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation

Nadezhda V. Yagovkina – Cand. Sci. (Med.), Associate Professor of the Department of Obstetrics and Gynecology

Kirov

A. G. Obrezan
Limited Liability Company «My Medical Center» (MMC LLC)
Russian Federation

Andrei G. Obrezan – Dr. Sci. (Med.), Professor, Chief Doctor

St. Petersburg

A. G. Chuchalin
State Budgetary Healthcare Institution of the city of Moscow «D.D. Pletnev City Clinical Hospital of the Department of Health of the City of Moscow» (GBUZ «GKB named after D.D. Pletnev DZM»)
Russian Federation

Aleksandr G. Chuchalin – the RAS Academician, Dr. Sci. (Med), consultant of the Department of Intensive Care and Intensive care Unit

Moscow

M. P. Kostinov
Federal State Budgetary Scientific Institution «I.I. Mechnikov Vaccine and Serum Research Institute»; Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Mikhail P. Kostinov – the RAS Corresponding Member, Dr. Sci. (Med), Professor, Honored Scientist of the Russian Federation, Head of the Laboratory of the I.I. Mechnikov Federal State Budgetary Scientific Research Institute; Head of the Department of Epidemiology and Modern Vaccination Technologies, Sechenov First Moscow State Medical (Sechenovskiy University)

Moscow

V. V. Popov
Private healthcare institution «Clinical Hospital «RZD-Medicine named after N.A. Semashko» (CHUZ KB RZD-Medicine named after Semashko)
Russian Federation

Vladimir V. Popov – Dr. Sci. (Med), Professor, doctor of clinical Pharmacology

Moscow

I. V. Feldblum
The Federal State Budgetary Scientific Institution «Izmerov Research Institute of Occupational Health»; Federal State Budgetary Educational Institution of Higher Education «Perm State Medical University named after Academician E.A.Wagner» of the Ministry of Health of the Russian Federation
Russian Federation

Irina V. Feldblum –Dr. Sci. (Med), Professor, Leading Researcher at the Federal State Budgetary Budgetary Institution «Scientific Research Institute of MT», Moscow; Federal State Budgetary Educational Institution of Higher Education «Perm State Medical University named after Academician E.A. Wagner» of the Ministry of Health of the Russian Federation

Moscow, Perm

U. M. Tomaev
The State Budgetary healthcare Institution of the Moscow region «Elektrostal Central City Hospital»
Russian Federation

Uruzmag M. Tomaev – allergist-immunologist

Moscow region

A. N. Galustyan
Limited Liability Company «Medical Technologies» (LLC «Medical Technologies»); State Budgetary Institution of Higher Professional Education «Saint-Petersburg state pediatric Medical University» Head of the Department of Pharmacology with the course of clinical pharmacology and pharmacoeconomics
Russian Federation

Anna N. Galustyan – Cand. Sci. (Med.), Chief Physician of Medical Technologies LLC

St. Petersburg

N. N. Ryndyuk
Federal State Budgetary Healthcare Institution Medical and Sanitary Unit No. 163 of the Federal Medical and Biological Agency of Russia
Russian Federation

Natalia N. Ryndyuk – Neurologist, deputy chief of medical department

Novosibirsk

A. K. Korduban
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Anastasia K. Korduban – Head of Clinical Trials team

Moscow

A. A. Kovpak
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Anastasia A. Kovpak – Head of the group of purification processes and formulation of finished dosage forms

Moscow

G. A. Malkin
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Gennady A. Malkin – Deputy Head of the Department for Development and Implementation of Innovative and Semi-Industrial Technologies

Moscow

A. N. Piniaeva
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Anastasia N. Piniaeva – Cand. Sci. (Biol.), Chief technology Officer

Moscow

Yu. Yu. Ivin
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Yury Yu. Ivin, Cand. Sci. (Biol.), Head of the Department for Development and Implementation of Innovative and SemiIndustrial Technologies

8, building 1, Poliomyelitis Institute settlement, internal territorial city, Filimonkovsky municipal district, Moscow, 108819

E. A. Korduban
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)
Russian Federation

Ekaterina A. Korduban – Head of Regulatory Affairs and Sales

Moscow

A. A. Ishmukhametov
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis); Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Aydar A. Ishmukhametov – the RAS Academician, Dr. Sci. (Med), professor, General manager Chumakov FSC R&D IBP RAS (Institute of Poliomyelitis)

Moscow

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