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Influence of Bacillus anthracis 34F2 Sterne Antigen Preparations in Combination with Cobaltarabinogalactan on the Subpopulation Structure of B-lymphocytes (Communication 2)

https://doi.org/10.31631/2073-3046-2015-14-2-107-112

Abstract

Study of Bacillus anthracis 34F2 Sterne antigenic preparation S-2 and its combined use with nanostructured cobalt-arabinogalaktan (Со-АG) is presented. The ability of these preparations to stimulate proliferation and differentiation of B-lymphocytes is demonstrated. However, content of the B-lymphocyte circulating subpopulations depends on the time of observation. Co-AG exhibits adjuvant properties enhanced the immunogenic features of the S-2 B. anthracis 34F2 Sterne that may indicate its availability as an adjuvant in the construction of chemical vaccines.

About the Authors

V. V. Voytkova
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


V. I. Dubrovina
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


S. V. Lukyanov
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


O. V. Yuryeva
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


O. B. Kol’Esnikova
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


K. M. Korytov
Irkutsk Institute of Chemistry named of A.E. Favorsky of the Siberian Branch of Russian Academy of Sciences
Russian Federation


G. P. Aleksandrova
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


V. P. Iljin
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


S. V. Balakhonov
Irkutsk Antiplague Research Institute of Siberia and the Far East of Federal Service on Customers’ Rights Protection and Human Well-Being Surveillance
Russian Federation


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Review

For citations:


Voytkova V.V., Dubrovina V.I., Lukyanov S.V., Yuryeva O.V., Kol’Esnikova O.B., Korytov K.M., Aleksandrova G.P., Iljin V.P., Balakhonov S.V. Influence of Bacillus anthracis 34F2 Sterne Antigen Preparations in Combination with Cobaltarabinogalactan on the Subpopulation Structure of B-lymphocytes (Communication 2). Epidemiology and Vaccinal Prevention. 2015;14(2):107-112. (In Russ.) https://doi.org/10.31631/2073-3046-2015-14-2-107-112

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ISSN 2073-3046 (Print)
ISSN 2619-0494 (Online)