Prevalence of Extensively Drug-Resistant Tuberculosis: a Descriptive Study
https://doi.org/10.31631/2073-3046-2018-17-4-13-19
Abstract
Background. Extensively drug-resistant tuberculosis (XDR-TB) is a threat to community health. Goal. The estimation of the prevalence of extensively drug-resistant tuberculosis in Omsk region, along with the clinical and epidemiological description of patients with XDRTB. Methodology. A retrospective descriptive epidemiologic research of tuberculosis morbidity in Omsk region in 2006–2017 was conducted.Results. The prevalence of extensively drug-resistant tuberculosis in Omsk region in 2006–2017 was stable at 35.6 per 100ths population with Tinc.=1.0%. The prevalence of extensively drug-resistant tuberculosis in Omsk region was 13.6 per 100ths population (n = 267). Among patients with XDR-TB the majority was of young working age 25–44 years (63.2%), male gender (80.9%), officially unemployed (75.6%), ill for at least 3 years (57.0%), suffering from infiltrative pulmonary tuberculosis (69.2%) and HIV-infected (31.8%). The resistance to seven first and second line antituberculosis drugs was found in 10.1% of patients with XDR-TB. Conclusions. The optimisation of approaches to the organization of additional measures for the prevention of extensively drug-resistant tuberculosis is needed.
About the Authors
O. A. Pasechnik
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Oksana A. Pasechnik – Cand. Sci. (Med.), senior lecturer of Department of Epidemiology
644050, Omsk, Mira str., 9
A. A. Zimoglyad
Center for Hygiene and Epidemiology in the Omsk Region
Russian Federation
Russian Federation
Еpidemiologist
644116, Omsk, 27 Severnaya Str., 42a
I. V. Yarusova
Clinical Antituberculosis Dispensary
Russian Federation
Russian Federation
Bacteriologist
644058, Omsk, Tselinnaya str., 2
S. V. Vitriv
Clinical Antituberculosis Dispensary
Russian Federation
Russian Federation
Stanislav V. Vitriv – head of the bacteriological laboratory
644058, Omsk, Tselinnaya str., 2
A. I. Blokh
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Alexey I. Blokh – assistant of Department of Epidemiology
644050, Omsk, Mira str., 9
References
1. WHO. Global tuberculosis report 2017. Available at: http://www.who.int/tb/publications/global_report/ru.
2. Gandhi N.R., Weissman D., Moodley P., Ramathal M., Elson I., Kreiswirth B.N., et al. Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa. J. Infect. Diss. 2013; 207 (1): 9–17.
3. Martinez L., Shen Y., Mupere E., Kizza A., Hill P.C., Whalen C.C. Transmission of Mycobacterium Tuberculosis in Households and the Community: A Systematic Review and Meta-Analysis, Am. J. Epidemiol. 2017; 185 (12): 1327–1339.
4. Yang C., Luo T., Shen X, Wu J., Gan M., Xu P. et al. Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and epidemiological investigation. Lancet Infect. Diss. 2017;17(3):275-284.
5. Jassa M., Bishai W.R. Extensively drug-resistant tuberculosis. Lancet Infect. Diss. 2009; 9 (1): 19–30.
6. Pasechnik O. A., Rudneva S. N., Tatarintseva M. P. Changes in tuberculosis epidemiological rates in Omsk region. Tuberkulez i bolezni legkih. [Tuberculosis and Lung Diseases]. 2015; 5: 139–140 (in Russian).
7. Pasechnik O. A., Stasenko V. L., Blokh A. I. Epidemic manifestations of tuberculosis in regions of Siberia with various prevalence of HIV infection. Epidemilogia i Vaccinoprofilactica. [Epidemiology and Vaccinal Prevention] 2015; 5 (84): 31–35 (in Russian).
8. Pietersen E., Ignatius E., Streicher E.M., Mastrapa B., Padanilam X., Pooran A., et al. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. Lancet. 2014; 383 (9924): 1230–1239.
9. Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 Global report on surveillance and response. Available at: http://apps.who.int/iris/bitstream/handle/10665/44286/9789241599191_eng.pdf
10. Erimbetov K. D., Bektursinov B. U., Zetov A. S. Efficiency of valve bronchial block within comprehensive treatment of pulmonary tuberculosis patients with extensive drug resistance. Tuberculosis and Lung Diseases. Tuberkulez i bolezni legkih. [Tuberculosis and Lung Diseases]. 2018; 96 (4): 47–51 (in Russian).
11. Ershovа E. S., Pаvlovа M. V., Vlаdimirov A. V., Revyakin E. A. Epidemic situation and treatment prospects of multiple resistant tuberculosis in Kanty-Mansiysky autonomous region. Tuberculosis and Lung Diseases. Tuberkulez i bolezni legkih. [Tuberculosis and Lung Diseases]. 2018; 96 (4): 5–11 (in Russian).
12. Eliseev P. I., Detjen A., Dacombe R., Pillips P., Squire S.B., Maryandyshev A.O. Impact of molecular genetic methods on the initiation of chemotherapy in multiple drug resistanttuberculosis patients in Arkhangelsk region. Tuberkulez i bolezni legkih. [Tuberculosis and Lung Diseases]. 2017; 95 (12): 10–17 (in Russian).
Review
For citations:
Pasechnik O.A., Zimoglyad A.A., Yarusova I.V., Vitriv S.V., Blokh A.I. Prevalence of Extensively Drug-Resistant Tuberculosis: a Descriptive Study. Epidemiology and Vaccinal Prevention. 2018;17(4):13-19. (In Russ.) https://doi.org/10.31631/2073-3046-2018-17-4-13-19
Views:
868
Email this article 