The article is devoted to the conditions of applicability of parametric and nonparametric methods, including criticism of frequent methodological errors. By using methods of parametric statistics often make the wrong conclusion that to test the applicability of methods of parametric statistics need to find out whether there are significant differences resulting from the normal allocation of the pilot. Doing this is not necessary, as any encountered in biomedical research component is distributed clearly abnormal. Besides, for the practical application of parametric statistics need sufficient proximity to the source distribution is not normal, and the arithmetic mean from a set of observations. The article stated, under any circumstances and for any amount of observational techniques can be used parametric statistics and how it relates to the value of kurtosis, and what the margin of error calculation of significant differences when using methods of parametric statistics. Subjected to a critical analysis and methods of nonparametric statistics. With their more formal precision and breadth of applicability, however, they checked less valuable statistical hypothesis, as in fact do not work with the values, and their ranks, and the ranking much of the information is lost.

A calculation method and a variation method of parameters of the epidemic situation model taking into account external risks is proposed. The detailed step-by-step algorithm available in the application Exel for the calculation and analysis of the model parameters based on the results of observations is given. The prognosis of the epidemic situation with the estimation of the disease outbreak duration and the total number of population members involved in the outbreak is constructed. We investigated the epidemic situation by an example of reports of a diseases group acute viral respiratory infections-flu in one of the districts of the Moscow region.

Modeling single and double vaccination in consideration of the natural immunization.Gives estimates of indicators of incompetence and redundancy of the immunization.

In this paper the authors are presenting the analysis of an economic burden caused by influenza and acute respiratory viral infections (ARVI). This is the first study of its kind in the Kyrgyz Republic. The goal of the study was to calculate the economic burden caused by the flu and ARVI morbidity in the Republic. The study was done during 2013 - 2014 on the basis of two hospitals among inpatients and in the basis of a policlinic in the city of Bishkek among outpatients. We found that the cost of one case of flu or ARVI was 4771.41 kyrgyz som (USD 97.79). In the overall structure, the cost of medical expenses was lower than the cost of non-medical expenses (41.3 compared to 58.7%). Results of this study allowed for the first time in Kyrgyzstan to calculate the total cost for treatment of ARVI and influenza in the country. For the year 2013 they amounted to 636 516 889.2 kyrgyz som or USD 13,835,558.85. Results of the study allowed determining the factors that influence the costs that medical institutions and patients face, as well as come up with recommendations on the need for preventive vaccination against influenza.

On the territory of the Siberian Federal District 2005 - 2014 period was characterized by a moderate tendency to reduce the incidence of tuberculosis and marked increase in the incidence of HIV infection. The subjects of the Siberian Federal District, the prevalence of HIV infection in which exceeded the level of 705.0 per 100 thousand people, had significant differences in the incidence rates of tuberculosis (115.4), the prevalence of tuberculosis (278.6 per 100 thousand), disability (73.3 per 100 thousand) and deaths from TB infection (25.5 per 100 thousand). The unfavorable short-term outlook for the morbidity of HIV-associated tuberculosis requires a change in approaches to epidemiological surveillance system for HIV and TB.

For the first time the current situation with tick-borne infections in recreational places of the Republic of Buryatia is evaluated. According to the data of the Center for diagnostic and prophylaxis of tick-borne infections (Irkutsk) collected in 2007 - 2014 the tick-borne encephalitis, Lyme disease, monocytic ehrlichiosis and granulocytic anaplasmosis are widely spread in most popular recreational places of south coast of the Baikal Lake and Tunka valley.

Colorectal cancer (CRC) dominants in incidence and mortality among all malignant tumors, it is observed both globally and different regions of Russia. The results of analytical epidemiological study «case-control» on the impact of the colorectal cancer risk factors are presented. Considered risk factors were associated with the sources of water consumption and the some features of diet in Permski Krai. Questionnaire surveys of 200 patients with CRC and 200 healthy individuals were performed. Observation and control groups were spread evenly by sex, age and ethnicity. It was determined following risk factors: consumption of municipal unboiled water and well water, sour cream intake, high concentration of salt in the food, fat, fried and spicy meal as well. There were protective factors such us consumption of municipal boiled water and intake of total dairy products more than 1000 g per week.

High-tech methods of surgical treatment of cardiac patients older than 65 years are the only means the ineffectiveness of drug treatments prolong their life and improve its quality. The analysis of the postoperative period of 5 years (2009 - 2013) cardiac patients older than 65 years compared with patients up to 65 years. The study used epidemiological and microbiological methods. The frequency of postoperative infectious complications was higher in patients older than 65 years In the structure of pathogens isolated from blood dominated negative bacteria: Acinetobacter spp., Klebsiella spp., Pseudomonas aeruginosa. There was a trend to a decrease in mortality in older patients in the dynamics over the years.

Currently, the problem of prevention and treatment of healthcare-associated infections (HAI), only in hospitals from 5 to 20% of patients HAI get sick. In Chelyabinsk region, in comparison with the Russian Federation, the quantity of the infections connected with delivery of health care tends to growth. The greatest number of HAI is registered in hospitals of a surgical profile 70.3 ± 5.7% (in the Russian Federation - 31.4 ± 0.2%). In area hospital-acquired pneumonia steadily holds the first - second place in structure of HAI (38.2 ± 10.3%) in the country - the fourth - fifth (10.1 ± 5.1%). Detection of distinctions in structure of HAI in Chelyabinsk region and in the country in general demand further studying for the purpose of identification and introduction of the most effective preventive and antiepidemic actions.

The article presents the research results of the non-specific immune factors of guinea pigs immunized the antigenic preparation strain Bacillus anthracis Sternе 34F₂ per se and combinated with cobaltarabinogalactan and argentogalactomannan. It is established that antigenic preparation and nanocomposites can stimulate oxygen- and nitric oxygen-dependent bactericidal systems of the experimental animal phagocytes and they can be used to construction of a chemical vaccine against anthrax.

The paper presents data on changes in the respiratory part of lungs of white mice with experimental plague caused by Yersinia рestis strains with different plasmid composition of Tuva and Gorno-Altaisk natural foci of plague and breeding clones. Morphological and structural changes in the lungs, which appear different degree of activation of the immune response and the severity of the pathological process caused by Y. pestis subsp. altaica and Y. pestis subsp. pestis and their isogenic plasmid options.

The informational article presents the results carried out in the Laboratory of Biotechnology Research Institute of Influenza original, promising development of drugs monoclonal antibodies, which are the basis of accurate diagnostic test systems, can be used to control the process of the evolution of pathogens flu and acute viral respiratory infections, as well as to create predictive models of their variability. The paper provides a list developed by the Research Institute of Influenza monoclonal antibodies and some examples of their use.

Tick-borne encephalitis (TBE) is a disease mainly affecting the central nervous system, serious medical and social problem in Russia and many European countries. TBE virus (TBEV) genetically divided into three major subtypes: the Far Eastern, European and Siberian. Siberian subtype of TBEV dominates in most part of Russia outside of the Far East. Modern cultural inactivated vaccine of domestic and foreign production prepared from the strains of the Far Eastern and European subtypes. In a review of the literature and our own researches are shown: the dominance of Siberian subtype (TBE) and data of vaccine-prevention. The importance of genetic differences between the Siberian subtype strains and vaccines strains are analyzed as well new approaches of the test strain selection.

This paper reviews the problems of passive immunization of rabies. In the Russian Federation remains serious epizoot-epidemiological situation of rabies, characterized the increase of the number of disadvantaged settlements and the registration of the hydrophobia in the population. In these circumstances the only possibility to prevent the disease in humans who suffered from the bite of a rabid animal, is timely and appropriate the administration of modern anti-rabies drugs.

Data on the current vaccination process have in sickly children with disorders of the central nervous system, and grafted lifeless live vaccines against diphtheria, measles and mumps.The levele of intercurrent diseases in every group was 33,3%. The post-vaccination period in 73% vaccination to diphtheria are asymptomatic (and after measles mumps vaccination in 86%). The post-vaccination reactions were in 50% illness children. The antibody titers seronegative was not identified. Children with epilepsia need to determine antibody titers sixs months after vaccination against measles and mumps to decide on supplementary immunization.

Recommendations highlighted features vaccination of children with rheumatic diseases. It is shown how the immunization scheme may be changed according to the pathology and the age of the child.